CAPN1 Promotes Pseudomonas aeruginosa-Induced Infection by Interacting with TFEB and Inhibiting Autophagy.

Introduction: Autophagy-lysosome pathways play a crucial role in the intracellular killing of pathogenic microorganisms. This study aimed to explore the mechanism by which acute lung injury (ALI) of Pseudomonas aeruginosa affects the autophagy-lysosome pathway.

Methods: ALI mouse models were induced by lipopolysaccharide and P.

Value of diaphragmatic ultrasound parameters in assessing weaning outcomes and survival in ventilator-dependent intensive care unit patients.

Objective: To retrospectively evaluate the utility of diaphragmatic ultrasound parameters in assessing ventilator weaning outcomes and survival in ventilator-dependent intensive care unit (ICU) patients.

Methods: A total of 105 ventilator-dependent ICU patients admitted to our hospital between October 2019 and February 2024 were included in this study. Depending on weaning outcomes, patients were divided into a successful group (n = 86) and a failure group (n = 19).