Molecular Hybrids Integrated with Benzimidazole and Pyrazole Structural Motifs: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies.

Synthesis of a series of benzimidazole-ornamented pyrazoles, has been obtained from arylhydrazine and aralkyl ketones via a multistep synthetic strategy. Among them, a hybrid-possessing -nitrophenyl moiety connected to a pyrazole scaffold () exerted the highest anti-inflammatory activity, which is superior to the standard, diclofenac sodium. While executing the 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, a hybrid-possessing -bromophenyl unit integrated at the pyrazole structural motif () exhibited the highest activity among the hybrids examined.