Prognostic value and immune cell infiltration of hypoxic phenotype-related gene signatures in glioblastoma microenvironment.

Glioblastoma (GBM) is a malignant intracranial tumour with the highest proportion and lethality. It is characterized by invasiveness and heterogeneity. However, the currently available therapies are not curative.

ZCCHC10 suppresses lung cancer progression and cisplatin resistance by attenuating MDM2-mediated p53 ubiquitination and degradation.

The activation of p53 tumor suppressor is essential for preventing abnormal cell proliferation and carcinogenesis. ZCCHC10 was previously identified as a potential p53-interacting partner in a yeast two-hybrid screen, but the interaction in cells and its subsequent influence on p53 activity and cancer development have not been investigated. In this paper, we demonstrate that ZCCHC10 expression levels are statistically lower in lung adenocarcinoma tissues than the corresponding adjacent noncancerous tissues, and decreased expression of ZCCHC10 mRNA predicts poorer survival of the patients.

CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression.

Background: Dysfunction of p53 is a key cause of cancer development, while CCDC106 can reduce p53 stability and is associated with lung cancer. However, the roles of CCDC106 in other cancer types and its upstream regulators have not been investigated.

Methods: The phosphorylation status was investigated by in vitro kinase assay and Western blotting using phosphorylation-specific antibodies.

Effects of extracellular polymeric substances on granulation of anoxic sludge in sequencing batch reactor.

Variations of extracellular polymeric substances (EPS) and its components with sludge granulation were examined in a lab-scale sequencing batch reactor (SBR) which was fed with sodium nitrate and sodium acetate. Ultrasonication plus cation exchange resin (CER) were used as the EPS extraction method. Results showed that after approximately 90 d cultivation, the sludge in the reactor was almost granulated.

[Insulin sensitivity and pancreatic beta cell function changes during the transformation from normal to impaired glucose tolerance].

Objective: To investigate the roles of insulin sensitivity and pancreatic beta cell function in the pathogenesis of type 2 diabetes.

Methods: 70 subjects were recruited in a 3-year prospective study. During this period 9 subjects progressed from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) (progressing group), 45 remained same (remaining group) and 16 improved from IGT to NGT (improving group).