Publications by authors named "Shunlian Hu"
Background: Ambient pollution and non-optimal temperature are major risk factors for respiratory health. However, the relationships between short-term exposure to these factors and bronchiectasis mortality remain unknown.
Methods: A nationwide, time-stratified case-crossover study across Mainland China was conducted from 2013 to 2019.
Article Synopsis
- * It identifies that COPD patients with PH have lower levels of DHA and certain DHA-derived oxylipins compared to those without PH, indicating these molecules may be linked to the risk of developing PH.
- * Additionally, the research suggests that DHA could potentially reduce the risk of PH by inhibiting interferon secretion, supported by findings of higher interferon levels in COPD-PH patients.
Background: Pulmonary hypertension (PH) is characterized by progressive pulmonary arterial remodelling, associated with different severities of inflammation and altered immune processes. Disulfiram eliminates the formation of N-gasdermin D (GSDMD) plasma membrane pores to prevent pyroptosis. Pyroptosis is a form of lytic cell death characterized by inflammasome activation and proinflammatory cytokine release that acts in the development of PH.
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