Metronomic capecitabine inhibits liver transplant rejection in rats by triggering recipients' T cell ferroptosis.

Background: Capecitabine (CAP) is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation (LT) in clinical studies. Our previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress in healthy mice. Ferroptosis, a newly defined non-apoptotic cell death that occurs in response to iron overload and lethal levels of lipid peroxidation, is an important mechanism by which CAP induces cell death.

Nomogram based on spleen volume expansion rate predicts esophagogastric varices bleeding risk in patients with hepatitis B liver cirrhosis.

Background: We aimed to explore the risk factors for hemorrhage of esophagogastric varices (EGVs) in patients with hepatitis B cirrhosis and to construct a novel nomogram model based on the spleen volume expansion rate to predict the risk of esophagogastric varices bleeding.

Methods: Univariate and multivariate logistic regression analysis was used to analyze the risk factors for EGVs bleeding. Nomograms were established based on the multivariate analysis results.

Integrative Multi-Omics Analysis of Identified Ferroptosis-Marker RPL8 as a Candidate Oncogene Correlates with Poor Prognosis and Immune Infiltration in Liver Cancer.

Background: Liver Hepatocellular Carcinoma (LIHC) is characterized by high malignancy, poor prognosis, and high recurrence rate worldwide. The role of ferroptosis in tumorigenesis and progression has been confirmed in previous studies. However, the multi-omics analysis in liver cancer of ferroptosis-markers RPL8 remains to be elucidated.

New insights into physicochemical properties of different particulate size-fractions and dissolved organic matter derived from biochars and their sorption capacity for phenanthrene.

To improve the knowledge of the heterogeneity and sorption behavior of biochars on hydrophobic organic contaminants (HOCs), pristine biochars (PBCs, 400 and 700 °C) were fractionated into four particulate fractions (SBCs) and dissolved organic matter derived from biochars (DBC), then the sorption capacities of them towards phenanthrene were examined. Results showed that the OC-normalized sorption distribution coefficients (K) of PBCs were generally at intermediate levels among that of SBCs and DBCs. The logK values of SBCs increased as particle sizes decreased.

Capecitabine Regulates HSP90AB1 Expression and Induces Apoptosis via Akt/SMARCC1/AP-1/ROS Axis in T Cells.

Transplant oncology is a newly emerging discipline integrating oncology, transplant medicine, and surgery and has brought malignancy treatment into a new era via transplantation. In this context, obtaining a drug with both immunosuppressive and antitumor effects can take into account the dual needs of preventing both transplant rejection and tumor recurrence in liver transplantation patients with malignancies. Capecitabine (CAP), a classic antitumor drug, has been shown to induce reactive oxygen species (ROS) production and apoptosis in tumor cells.

Capecitabine Can Induce T Cell Apoptosis: A Potential Immunosuppressive Agent With Anti-Cancer Effect.

Capecitabine (CAP) is now widely used in the comprehensive treatment of digestive system tumors. Some clinical observations have shown that CAP may have immunosuppressive effects, but there is still a lack of clear experimental verification. In this study, different doses of CAP were administered to normal mice by gavage.

Applicability Analysis of Determination Models for Nanopores in Coal Using Low-Pressure COâ‚‚ and Nâ‚‚ Adsorption Methods.

The development characteristics of nanopores (with pore sizes <200 nm) in coal are a key factor affecting the accumulation and migration of coalbed methane (CBM). Thus, an appropriate determination method and calculation model are essential for accurate nanopore representation. Based on the experiments of low-pressure COâ‚‚ adsorption (LP-COâ‚‚GA) at 273 K and low-pressure Nâ‚‚ adsorption (LP-Nâ‚‚GA) at 77 K on four coals with different ranks, the abilities of different models (e.

Mono and co-immobilization of imidazolium ionic liquids on silica: effects of the substituted groups on the adsorption behavior of 2,4-dinitrophenol.

Ionic liquid modified silicas with high adsorption capacity for phenols prompt us to deeply explore the contribution of interactions between the adsorbent and adsorbate, with a particular focus on hydrophobicity, π-π, electrostatic and acid-base interactions. Herein, by introducing a series of typical substituent groups including ,-dimethylaminopropyl (A), benzyl (B), dodecyl (D) and naphthylmethyl (N) in an imidazole ring (Im), three mono-immobilized and two co-immobilized imidazolium ionic liquid modified silicas, namely SilprAImCl, SilprBImCl, SilprNImCl, SilprDBImCl and SilprDAImCl, werre synthesized for removal and recovery of 2,4-dinitrophenol (2,4-DNP) from aqueous solutions. Adsorption kinetics, isotherms, thermodynamic analysis and desorption experiments have been carried out.

Post-column detection of benzenediols and 1,2,4-benzenetriol based on acidic potassium permanganate chemiluminescence.

Based on the sensitizing effect of formic acid on the chemiluminescence (CL) reaction of polyhydroxylbenzenes with acidified potassium permanganate and the combination technique of high-performance liquid chromatography (HPLC), a sensitive, selective and simple post-column CL detection method for simultaneously determining catechol, resorcinol, hydroquinone and 1,2,4-benzenetriol is described. The optimal conditions for the CL detection and HPLC separation were carried out. The linear ranges were: 6.

Flocculation-ultrasonic assisted extraction and solid phase clean-up for determination of polycyclic aromatic hydrocarbons in water rich in colloidal particulate with high performance liquid chromatography and ultraviolet-fluorescence detection.

In the present work, a simple method of sample preparation for the determination of polycyclic aromatic hydrocarbons (PAHs) in water rich in colloidal particulate was developed. The technique was mainly based on the effect of the flocculation of aluminum sulfate and the adsorption of the flocculation aid florisil. The method contained three steps: flocculation, ultrasonic extraction, and solid-phase extraction cleanup.

Flow-injection analysis for the determination of total inorganic carbon and total organic carbon in water using the H2O2-luminol-uranine chemiluminescent reaction.

In the presence of carbonate and uranine, the chemiluminescent intensity from the reaction of luminol with hydrogen peroxide was dramatically enhanced in a basic medium. Based on this fact and coupled with the technique of flow-injection analysis, a highly sensitive method was developed for the determination of carbonate with a wide linear range. The method provided the determination of carbonate with a wide linear range of 1.

[Determination of dihydroxybenzenes using high performance liquid chromatography with acidic potassium permanganate chemiluminescence].

A sensitive, selective and simple post-column chemiluminescence (CL) detection method for simultaneously determining catechol, resorcinol, hydroquinone has been developed based on high performance liquid chromatography (HPLC) coupled with CL detection using reaction of dihydroxybenzenes with acidified potassium permanganate solution with the enhancing effect of formic acid. The optimal conditions for the CL detection and HPLC separation were achieved. Dihydroxybenzene isomers were baseline separated at column temperature of 25 degrees C using a mobile phase of methanol-0.