Targeting nutrient metabolism has been proposed as an effective therapeutic strategy to combat breast cancer because of its high nutrient requirements. However, metabolic plasticity enables breast cancer cells to survive under unfavorable starvation conditions. The key mammalian target regulators rapamycin (mTOR) and hypoxia-inducible-factor-1 (HIF-1) tightly link the dynamic metabolism of glutamine and glucose to maintain nutrient flux.
View Article and Find Full Text PDFZhongguo Dang Dai Er Ke Za Zhi
July 2011
Objective: To study the prognosis and the factors affecting the prognosis in children with acute respiratory distress syndrome (ARDS).
Methods: Seventy-eight children with ARDS were enrolled. The states of their survival within 30 days were followed-up.