Bone CYP27B1 gene expression is increased with high dietary calcium and in mineralising osteoblasts.

Although the regulation of renal 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1) is reasonably well understood, the same cannot be said about the regulation of bone CYP27B1 expression. We have compared the regulation of kidney and bone CYP27B1 expression with modulation of dietary vitamin D and calcium levels. Vitamin D-deplete and vitamin D-replete female Sprague-Dawley rats were fed either 1% Ca (HC) or 0.

[Implant therapy for bone loss in the premaxillar part of the bilateral cleft lip and palate patient].

Patient: A 19-year-old female patient presented to our hospital for orthodontic treatment. She had a bilateral cleft lip and palate and had lost bone on premaxilla and both sites of central and lateral incisor teeth. She received a bone graft from ilium and prosthetic treatment supported by dental implants.

CYP24 promoter activity is affected by mechanical stress and mitogen-activated protein kinase in MG63 osteoblast-like cells.

Purpose: For bone homeostasis, vitamin D plays an important role in the regulation of calcium. The enzyme CYP24 inactivates vitamin D and is involved in its regulation. However, the mechanism of expression of CYP24 in osteoblastic cells under mechanical stress is not clear.