Publications by authors named "Shuning Tian"
Article Synopsis
- Chronic wounds like venous leg ulcers and diabetic foot ulcers suffer from low oxygen levels, which makes healing difficult and impacts patients' quality of life.
- Traditional oxygen therapies often face challenges including inadequate oxygen delivery, limited treatment time, and safety concerns.
- Recent advancements in artificial photosynthetic systems show promise for enhancing oxygen levels at wound sites, offering continuous supply and improved safety, which could potentially speed up the healing process.
Mesenchymal-epithelial transition factor (C-Met) has been acknowledged as a significant therapeutic target for treating lung adenocarcinoma (LUAD). However, the potential application of chimeric antigen receptors (CAR)-modified natural killer (NK) cells targeting c-Met in LUAD is rarely explored. In this study, bioinformatic databases were searched and a tissue microarray (TMA) was enrolled to investigate expression status and prognostic role of c-Met in LUAD.
View Article and Find Full Text PDFBackground: Siglec-15 (S15) is a type-I transmembrane protein and is considered a new candidate of immune checkpoint inhibitor for cancer immunotherapy.
Methods: In the present study, we first constructed and characterized a chimeric S15-specific monoclonal antibody (S15-4E6A). Then, the antitumor effectiveness and modulatory role of S15-4E6A in macrophages (mφs) were explored in vitro and in vivo.
Myocardial cell injury caused by myocardial ischemia and reperfusion is one of the main causes of the occurrence and development of heart disease. Recent study has shown that inducing mitophagy of cardiomyocytes is a crucial method to alleviate ischemia-reperfusion injury. While, Polo-like kinase 1 (PLK1) can induce the mitophagy of breast cancer cells.
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