Seronegative neuromyelitis optica spectrum disorder in primary familial brain calcification with variant.

•This case indicates that the variant is associated with PFBC as well as with NMOSD.

Bromisoval-induced bromism with status epilepticus mimicking Wernicke's encephalopathy: report of two cases.

Background: Bromine compounds are used in several drugs, including over-the-counter drugs. They sometimes cause intoxication known as bromism. Although the acute neurological symptoms and sequelae of bromism vary, few reports have mentioned acute encephalopathy.

Intrafamilial phenotypic variation in spinocerebellar ataxia type 23.

Background: Spinocerebellar ataxia type 23 (SCA23) is an autosomal dominant cerebellar ataxia caused by pathogenic variants in the prodynorphin gene (). The frequency of variants is reportedly very low (~ 0.1%) in several ataxia cohorts screened to date.

Low-level laser therapy for prevention of noise-induced hearing loss in rats.

Noninvasive low-level laser therapy (LLLT) is neuroprotective, but the mechanism of this effect is not fully understood. In this study, the use of LLLT as a novel treatment for noise-induced hearing loss (NIHL) is investigated. Sprague-Dawley rats were exposed to intense noise and their right ears were irradiated with an 808nm diode laser at an output power density of 110 or 165mW/cm(2) for a 30min period for 5 consecutive days.

[A case of colchicine-responsive Mollaret's meningitis with MEFV gene mutation].

A 66-year-old woman was admitted to our hospital with recurrent meningitis. She presented with 10 episodes of meningitis in 10 months. Examination of cerebrospinal fluid demonstrated pleocytosis, with neutrophils dominant at the early stage, and lymphocytes dominant at the late stage.

[An autopsied case of postinfectious neuromyelitis optica in an 84-year-old man].

An 84-year-old man presented with acute bilateral visual impairment 2 weeks after an upper respiratory tract infection. A few days later, he developed left hemiparesis, followed by paraplegia. The brain magnetic resonance imaging (MRI) showed high-intensity lesions in the right cerebellum, pons, left and right corona radiata, and right putamen.

Intravascular large B cell lymphoma diagnosed by senile angioma biopsy.

An 82-year-old man without notable medical history was admitted to our hospital following subacute deterioration of apettite, disorientation and strange behavior. There was spasticity of the right extremities without weakness. LDH and serum soluble IL2 receptor antibody levels were elevated, and as well as the protein level and IgG levels in the cerebrospinal fluid.