Publications by authors named "Shunichi Gotani"
Cancers (Basel)
November 2023
Article Synopsis
- HIF-1α drives glycolysis in gliomas under low oxygen, supporting tumor growth and indicating higher risks of poor outcomes in affected dogs.
- Evofosfamide (EVO) targets hypoxic tumor regions and shows promise as a treatment by inhibiting glycolytic metabolism in cancer cells.
- Preclinical studies reveal that EVO reduces tumor development and alters cancer metabolism by eliminating HIF-1α-positive cells, which may benefit treatment strategies for canine gliomas.
