Publications by authors named "Shungo Hikoso"
Article Synopsis
- Undernutrition has a negative impact on patients with heart failure and preserved ejection fraction (HFpEF), affecting their long-term prognosis after discharge.
- A study categorized 547 HFpEF patients based on their nutritional status at discharge and one year later, identifying those who normalized or worsened in their nutritional scores.
- The findings revealed that worsening nutritional scores increased the risk of all-cause mortality or readmission, while improving scores were linked to better outcomes, with certain predictors identified for changes in nutritional status.
Objectives: N-terminal pro brain natriuretic peptide (NT-proBNP) is a biomarker for myocardial stress that is used in diagnosing and prognosticating heart failure (HF). However, its interpretation is complicated by clinical factors. This study aims to clarify the prognostic value of NT-proBNP in patients with heart failure with preserved ejection fraction (HFpEF), and risk-prediction cutoffs considering various clinical factors.
View Article and Find Full Text PDFBackground Recent guidelines recommend dual antiplatelet therapy (DAPT) for six months following percutaneous coronary intervention (PCI) in patients with chronic coronary disease, as unexpected hospitalization can trigger DAPT discontinuation. This study evaluated the predictive factors for unexpected hospitalization within six months after PCI in patients with chronic coronary disease. Methods This prospective multicenter study included 412 patients who underwent PCI for chronic coronary disease.
View Article and Find Full Text PDF: Coronary microvascular dysfunction (CMD) is associated with many heart diseases, including heart failure (HF) with preserved ejection fraction (HFpEF). Invasive examinations for CMD detection are difficult in older patients with HFpEF, and the decision criteria for noninvasive CMD measurements are unclear. We aimed to identify alternative factors in the possible involvement of CMD in the progression and prognosis of HFpEF.
View Article and Find Full Text PDFAims: Congestive heart failure (HF) is a common complication in patients with acute myocardial infarction (AMI). The estimated plasma volume status [ePVS = (100 - haematocrit)/haemoglobin] is used as the blood plasma volume index to determine the presence of congestion in patients with HF. However, the clinical impact of ePVS at discharge in patients with AMI remains unclear.
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- In a study analyzing treatments for persistent atrial fibrillation (AF), researchers compared extensive ablation techniques (including pulmonary vein isolation and additional methods) with just pulmonary vein isolation (PVI) in young (<65 years) and elderly (≥65 years) patients.
- They found that while both methods were equally effective in younger patients, extensive ablation significantly reduced AF recurrence in elderly patients.
- The study concluded that extensive ablation is a more effective treatment for elderly patients with persistent AF, without any serious procedural complications reported.
Article Synopsis
- The study analyzed the effects of coronary angioscopy (CAS) findings after the implantation of two types of stents: a polymer-free biolimus A9-coated stent (PF-BCS) and a durable polymer everolimus-eluting stent (DP-EES) in 99 patients, with evaluations done at 1 and 12 months post-implantation.
- Results showed a decrease in thrombi and yellow plaque from 1 month to 12 months, with no new thrombi but some new yellow plaque observed in patients with DP-EES.
- Key factors affecting thrombi development included management of diabetes, stent area, and stent coverage, highlighting that polymer
Article Synopsis
- Extensive ablation, when added to pulmonary vein isolation (PVI), shows varied effectiveness in patients with persistent atrial fibrillation (AF), especially in those with mitral regurgitation (MR).
- A post-hoc analysis from the EARNEST-PVI trial revealed that while PVI alone and PVI-plus had similar recurrence rates in non-MR patients, PVI-plus significantly reduced AF recurrence in MR patients.
- The study suggests that customizing ablation techniques based on MR presence can improve patient outcomes in AF treatment.
Background: It has not been fully elucidated which patients with persistent atrial fibrillation (PerAF) should undergo substrate ablation plus pulmonary vein isolation (PVI). This study aimed to identify PerAF patients who required substrate ablation using intraprocedural assessment of the baseline rhythm and the origin of atrial fibrillation (AF) triggers.
Methods and results: This was a post hoc subanalysis using extended data of the EARNEST-PVI trial, a prospective multicenter randomized trial comparing PVI-alone and PVI-plus (i.
Aims: Blood stasis is crucial in developing left atrial (LA) thrombi. LA appendage peak flow velocity (LAAFV) is a quantitative parameter for estimating thromboembolic risk. However, its impact on LA thrombus resolution and clinical outcomes remains unclear.
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- - The study investigates the role of Interleukin-16 (IL-16) in heart failure with preserved ejection fraction (HFpEF), focusing on its impact on different subtypes of the condition.
- - Researchers analyzed data from 211 patients, categorizing them into four phenogroups, finding that phenogroup 2 exhibited the highest IL-16 levels and related indicators of cardiac issues.
- - IL-16 levels were a significant predictor of all-cause death only in phenogroup 2, suggesting that IL-16's effects on heart failure may vary significantly across different subphenotypes.
Background: The relationship between baseline yellow plaque (YP) and vascular response after stent implantation has not been fully investigated.
Methods: This was a sub-analysis of the Collaboration-1 study (multicenter, retrospective, observational study). A total of 88 lesions from 80 patients with chronic coronary syndrome who underwent percutaneous coronary intervention were analyzed.
Article Synopsis
- The study focused on creating a tool to assess the risks of bleeding and thrombosis in patients with myocardial infarction undergoing percutaneous coronary intervention (PCI).
- It involved analyzing data from two patient cohorts: one for developing the tool (4554 patients) and another for validating it (2215 patients).
- The resulting model effectively stratified patients based on their risk probabilities, aiding in tailored treatment decisions for both STEMI and non-STEMI cases.
This study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). A total of 877 patients who underwent emergency PCI for AMI were examined. AKI was defined as serum creatinine (SCr) ≥ 0.
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- The study investigates how low LDL cholesterol, anemia, and low platelet levels affect outcomes in heart failure patients with preserved ejection fraction (HFpEF).
- Using data from 1021 hospitalized patients, they created a scoring system (LEP score) to evaluate the risk of all-cause death and heart failure readmission based on these factors.
- The findings showed that higher LEP scores correlated with an increased risk of negative outcomes, highlighting the importance of monitoring these three components in managing HFpEF patients.
Article Synopsis
- The study investigates how the duration of atrial fibrillation (AF) affects the success of catheter ablation in patients with long-standing AF (LsAF).
- It found that patients with LsAF lasting 1-2.4 years have similar outcomes to those with persistent AF (PerAF), but those with LsAF over 2.4 years face a higher risk of arrhythmia recurrence.
- Additionally, patients with LsAF over 2.4 years might benefit more from a combined ablation strategy (PVI-plus) than from a standard approach (PVI-alone).
Article Synopsis
- A study aimed to find patients with persistent atrial fibrillation (AF) who would benefit from extensive catheter ablation, using a machine learning method called uplift modeling.
- The research identified the best model as adaptive boosting, which indicated that an uplift score of 0.0124 could effectively determine who would benefit from the more extensive procedure.
- Results showed that patients with an uplift score of 0.0124 or higher had a significantly lower recurrence of AF with the extensive ablation (PVI-plus) compared to those receiving only the standard procedure (PVI-alone).
The coexistence of heart failure is frequent and associated with higher mortality in patients with type 2 diabetes (T2DM), and its management is a critical issue. The WATCH-DM risk score is a tool to predict heart failure in patients with type 2 diabetes mellitus (T2DM). We investigated whether it could estimate outcomes in T2DM patients with heart failure with preserved ejection fraction (HFpEF).
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- The study investigates the impact of β-blocker medications on the prognosis of patients with heart failure who have preserved ejection fraction (HFpEF), specifically focusing on the level of frailty as measured by the Clinical Frailty Scale (CFS).
- Among the 1159 patients analyzed, those with higher frailty (CFS ≥ 4) experienced worse outcomes, including higher rates of death and heart failure readmission when using β-blockers, while those with lower frailty (CFS ≤ 3) did not show significant negative effects.
- The findings suggest that careful consideration is necessary when prescribing β-blockers to frail HFpEF patients, as the risks may outweigh the benefits in this group.
Article Synopsis
- The study focuses on heart failure with preserved ejection fraction (HFpEF) and aims to understand the differences in biomarkers among its various phenotypes to shed light on their underlying mechanisms.* -
- It utilizes data from the PURSUIT-HFpEF Study, which includes 1,231 patients, and identifies four distinct HFpEF phenotypes based on biomarker measurements from a subset of 212 patients.* -
- Results show that each phenotype has unique biomarker profiles, suggesting differential pathophysiological mechanisms, particularly the role of inflammation in conditions like hypertension and cardiac hypertrophy.*
Article Synopsis
- Left ventricular mass index (LVMI) and left atrial volume index (LAVI) are critical echocardiographic parameters for evaluating structural changes in heart failure with preserved ejection fraction (HFpEF) but their impact on clinical outcomes is not fully understood.
- The study analyzed 960 HFpEF patients hospitalized for acute decompensated heart failure, categorizing them into four groups based on LVMI and LAVI thresholds, and assessed outcomes such as heart failure readmission and overall mortality over a median follow-up of 445 days.
- Results showed that patients with increased LAVI alone had a higher risk of heart failure readmission and mortality compared to those with increased LVMI, highlighting the importance of LAVI in
Article Synopsis
- * Researchers analyzed data from 36 HFpEF patients who started ASV therapy from 2012 to 2017 and compared the number of heart failure hospitalizations before and after starting ASV at home.
- * Results showed a significant decrease in hospitalizations for heart failure after ASV was introduced, particularly among female patients, those with a lower body mass index, and those with significant tricuspid valve regurgitation.