Publications by authors named "Shungang Xu"
Article Synopsis
- Renal interstitial fibrosis is common in lupus nephritis (LN), and a specific tRNA-derived small RNA, tiRNA002, is linked to its development, though the exact mechanism isn’t fully understood.
- In experiments, introducing tiRNA002 to tubular epithelial cells and MRL/lpr mice showed that it enhances the epithelial-mesenchymal transition (EMT) and increases fibrosis through Smad signaling.
- Targeting tiRNA002 could offer a new potential treatment to address renal interstitial fibrosis in patients with lupus nephritis.
Background: Both primary IgA nephropathy (IgAN) with and without nephrotic syndrome (NS) can present massive proteinuria (24-h urinary protein ≥3.5 g/d). The clinical significance of massive proteinuria may be different in the two entities and needs further research.
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