[mTOR/p70s6k signaling pathway is involved in megakaryocyte polyploidization].

Aim: To investigate the mechanisms of megakaryocyte polyploid cell cycle control.

Methods: The expression and phosphorylation of mTOR/p70s6k pathway proteins was detected by western blot. Double-labeling techniques were used to investigate in which of the phase of the polyploid cell cycle S6K1 at Thr421/Ser424 are phosphorylated.