Publications by authors named "Shun-Wang Li"
Acta Pharmacol Sin
October 2024
Article Synopsis
- - PCSK9 is a protein that binds to LDLR in the liver and causes its degradation, leading to higher cholesterol levels; targeting PCSK9 can help manage cholesterol levels and reduce conditions like hypercholesterolemia and atherosclerosis.
- - A new compound called E28362 was identified as a potential PCSK9 inhibitor through virtual screening, showing promise in increasing LDLR levels and reducing LDL cholesterol in lab tests and animal models.
- - In studies with hamsters and mice on high-fat diets, E28362 effectively lowered cholesterol and triglyceride levels and decreased atherosclerotic lesions, indicating its potential as a treatment for cholesterol-related diseases.
