Relationships of uPA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis.

Objective: To investigate uPA and VEGF expression in esophageal cancer and relations with tumorous invasion and metastasis.

Methods: Immunohistochemistry was used to detect uPA and VEGF expression in the normal epithelial tissue of esophageal mucosa and cancer tissue and detect CD34 labeled micrangium and analyze the relationships with clinical pathological features and tumor angiogenesis.

Results: Positive rates for uPA and VEGF protein expression were significantly greater in esophageal cancer than normal epithelial tissue (P < 0.