Generalized linear mixed-effects models for studies using different sets of stimuli across conditions.

A non-repeated item (NRI) design refers to an experimental design in which items used in one level of experimental conditions are not repeatedly used at other levels. Recent literature has suggested the use of generalized linear mixed-effects models (GLMMs) for experimental data analysis, but the existing specification of GLMMs does not account for all possible dependencies among the outcomes in NRI designs. Therefore, the current study proposed a GLMM with a level-specific item random effect for NRI designs.

The Local Anesthetic Bupivacaine Inhibits the Progression of Non-Small Cell Lung Cancer by Inducing Autophagy Through Akt/mTOR Signaling.

Non-small cell lung cancer (NSCLC) is a prevalent malignancy with high mortality and poor prognosis. Bupivacaine serves as a widely used local anesthetic and presents potential anti-tumor activity. Nevertheless, the function of bupivacaine in the NSCLC development remains elusive.