Publications by authors named "Shun Yin"
Erythrocyte membrane-coated nanocarriers modified by TGN for Alzheimer's disease.
J Control Release
February 2024
Article Synopsis
- Alzheimer's disease (AD) is characterized by the buildup of β-amyloid protein, and recent research highlights the use of bioactive material-based drug delivery systems for treatment, specifically using red blood cell (RBC) membrane-coated nanoparticles to deliver curcumin to the brain.
- A peptide called TGNYKALHPHN (TGN) was added to the nanoparticles to aid their transport across the blood-brain barrier, resulting in nearly eight times better delivery of the therapeutic agent compared to standard nanoparticles.
- In experiments, mice treated with the modified curcumin nanoparticles showed significant improvements in memory and cognitive function, as well as enhanced neuroprotection and reduced inflammation, indicating a potential new avenue for AD treatment.
Efficient brain drug delivery has been a challenge in the treatment of Alzheimer's Disease and other brain disorders as blood-brain barrier (BBB) impedes most drugs to reach brain. To overcome this obstacle, we developed a novel TGN decorated erythrocyte membrane-coated poly (lactic-co-glycolic acid) nanoparticle (TRNNs). The nanoparticle significantly boosted the penetration (7.
View Article and Find Full Text PDFBecause of the blood-brain barrier, only a limited fraction of drugs can penetrate the brain. As a result, there is a need to take larger doses of the drug, which may result in numerous undesirable side effects. Over the past few decades, a plethora of research has been conducted to address this issue.
View Article and Find Full Text PDFAlzheimer's disease (AD) is to blame for about 60% of dementia cases worldwide. The blood-brain barrier (BBB) prevents many medications for AD from having clinical therapeutic effects that can be used to treat the affected area. Many researchers have turned their attention to cell membrane biomimetic nanoparticles (NPs) to solve this situation.
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