Publications by authors named "Shun Kawaguchi"
Article Synopsis
- A Q&A from ICH S3A was published to promote the use of microsampling (MS) in toxicity evaluations, highlighting its potential to reduce the number of animals needed for toxicokinetic studies.
- The study investigated the effects of MS on toxicity evaluation in mice after administering 1-naphthylisothiocyanate (ANIT), focusing on blood sample collection and its impact on liver and gallbladder injury indicators.
- Results showed MS influenced certain toxicity parameters, such as increased signs of liver damage and anemia, suggesting careful consideration is needed when using MS in mice for toxicological assessments.
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of video-assisted thoracoscopic surgery (VATS) for breast cancer patients with internal mammary lymph node metastases, which are less commonly treated surgically compared to axillary metastases.
- Researchers analyzed 34 patients with abnormal uptake in lymph nodes using PET/CT, identifying 11 who underwent VATS, with promising results showing no complications and an 80% positive predictive value for cancer detection.
- During an average follow-up of 17.9 months, most patients remained alive and relapse-free, although two experienced recurrence after surgery, suggesting VATS could be a safe option for treating internal mammary lymph node metastasis.
Article Synopsis
- Invasive lobular carcinoma (ILC) tends to grow in a subtle, single-cell pattern, making it challenging to detect axillary lymph node (ALN) metastases through MRI, especially when compared to invasive ductal carcinoma (IDC).
- A study analyzed MRI findings in 120 female patients with ILC to identify characteristics correlated with ALN metastasis, revealing that 29% had metastasis.
- The results indicated that focal cortical thickening (FCT) is possibly the most significant MRI indicator for predicting ALN metastasis in ILC, though further validation of this finding is necessary.
Solitary fibrous tumor of male breast: A case report and literature review.
Medicine (Baltimore)
December 2022
Article Synopsis
- Solitary fibrous tumors (SFT) are rare growths that can form anywhere in the body, but finding one in a man's breast is super uncommon, with only 8 cases known before this one.
- A 73-year-old man had a noticeable lump in his breast and was diagnosed with SFT after tests showed it had certain characteristics and after a biopsy confirmed it.
- The doctors successfully removed the tumor, and they used a special test called STAT6 immunostaining to help recognize it, marking this case as the first recorded instance of SFT in a male breast that tested positive for STAT6.
Article Synopsis
- The study evaluates the effectiveness of using combined PET/CT and MRI imaging to detect axillary lymph node metastasis in invasive ductal breast cancer (IDC), aiming to improve preoperative risk assessment for patients.
- Researchers analyzed data from 361 female patients, creating a prediction model to classify patients into low-risk and high-risk groups regarding ALN macrometastasis.
- The results showed that the model was effective, with a false-negative rate of 11% and an overall accuracy of 87.5%, suggesting it could help identify low-risk patients before surgery.
Introduction And Importance: Indocyanine green (ICG) fluorescence angiography is being increasingly performed intraoperatively to detect restricted blood flow intraoperatively for the prevention of postoperative organ ischemia and anastomotic leakage. This is the first case report of simultaneous laparoscopic distal gastrectomy (LDG) and spleen-preserving distal pancreatectomy (LSPDP) involving ICG angiography use to avoid the remnant stomach ischemia.
Case Presentation: A 55-year-old man was diagnosed with early cancer of the stomach body and intraductal papillary mucinous neoplasms of the pancreatic tail.
Background: Recently, the incidence of cytomegalovirus retinitis has increased, but indocyanine green angiography for cytomegalovirus retinitis has not been reported.
Case Outline: The patient, a 51-year-old male, had floaters in both eyes. White active lesions were evident in the mid-periphery of both eyes.