Publications by authors named "Shun He"

False smut caused by is one of the most destructive diseases in rice. The disease is primarily controlled with fungicides, leading to the development of fungicide resistance. Although spray-induced gene silencing (SIGS) has been utilized for disease management, it has not been applied to control rice false smut.

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Pulmonary delivery of anticancer therapeutics has shown encouraging performance in treating nonsmall cell lung cancer (NSCLC), which is characterized by high aggressiveness and poor prognosis. Cisplatin, a key member of the family of DNA alkylating agents, is extensively employed during NSCLC therapy. However, the development of chemoresistance and the occurrence of side effects severely impede the long-term application of cisplatin-based chemotherapies.

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Article Synopsis
  • RNA interference (RNAi) technology shows promise for pest control by targeting lethal genes and improving delivery systems.* -
  • A study identified the gene NlCYP303A1 in the rice pest Nilaparvata lugens, which, when silenced, caused deformities and increased mortality.* -
  • Using a nanocarrier named ZIF-8 improved the delivery and effectiveness of dsNlCYP303A1, highlighting its potential for enhancing RNAi pest control methods.*
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  • Facultative vertically transmitted symbionts are common in insects and can significantly influence their characteristics, but studying them is challenging due to difficulties in culturing these microbes and a lack of genetic tools.
  • Research on the brown planthopper (Nilaparvata lugens) revealed that a specific symbiont, Ca. Arsenophonus nilaparvatae, can be cultured and its entire genome sequenced, demonstrating its role in increasing the insect's susceptibility to insecticides.
  • The study also showed that this symbiont could be passed down to offspring, impacting the host's detoxification system, which has important implications for pest control and insecticide application strategies.
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  • MYB12 is an important gene that helps plants make certain beneficial compounds, but how it is controlled isn't fully understood.
  • Researchers discovered that another gene, NtMYB59, can stop the creation of some of these compounds in tobacco plants when it's overly active.
  • By studying the effects of NtMYB59 on MYB12, scientists found that NtMYB59 directly affects the expression of MYB12, which is key for producing these important plant materials.
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Psoriasis is a chronic inflammatory immune-related skin disease. According to literature reports, the leaves of Broussonetia papyrifera exhibit antioxidant, immune-enhancing and antibacterial effects. These leaves are not only used clinically for the treatment of superficial fungal infections and hepatitis, but also used in the development of health food.

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Background: Esophageal cancer poses a significant health burden globally. Endoscopic treatment has emerged as a viable option for patient ineligible for surgery or experiencing disease recurrence post-radiotherapy.

Methods: Patients visiting the Department of Endoscopy at the Cancer Hospital of China Academy of Medical Sciences between March 2009 and March 2024 were retrospectively analyzed.

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  • - UV-B radiation increases flavonoid production in plants for protection against oxidative damage, with the protein BES1 playing a key role in this process.
  • - Research showed that UV-B reduces the expression of certain transcription factors like NtMYB27, which inhibits flavonoid synthesis in tobacco.
  • - NtBES1 acts by binding to NtMYB27 to regulate its function, which in turn affects the synthesis of other compounds such as lignin and chlorogenic acid while suppressing flavonoid accumulation, indicating complex interactions during UV-B exposure in plants.
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An intelligent delivery nanoformulation could enhance the utilization efficacy, uptake, and translocation of pesticides in plants. Herein, a redox/pH-triggered and fluorescent smart delivery nanoformulation was designed and constructed by using hollow mesoporous organosilica nanoparticles (HMONs) and ZnO quantum dots as the nanocarrier and capping agent, respectively. Boscalid was further loaded to generate Boscalid@HMONs@ZnO with a loading rate of 9.

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is a significant global pest, and chlorantraniliprole (CAP) is extensively used in China for its control. Understanding CAP resistance in is crucial for effective management of this pest. Field populations exhibited varying degrees of resistance to CAP (RR = 1.

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Scopoletin and chlorogenic acid (CGA) are important polyphenols that regulate plant growth, development, and stress resistance. The ERF transcription factor WAX INDUCER1 (WIN1) promotes the biosynthesis of cutin, suberine, and wax. However, its full roles in regulating the accumulation of plant secondary metabolites still remain to be further clarified.

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Article Synopsis
  • The study explores how the RNA interference (RNAi) efficiency of double-stranded RNA (dsRNA) in feeding Nilaparvata lugens (a type of insect) is hindered by a specific endonuclease enzyme found in their gut.
  • Researchers identified a gene for this endonuclease, which is significantly active in the early development stages of the insect and suggests it disrupts oral RNAi when dsRNA is fed.
  • The findings indicate that the presence of this endonuclease reduces the stability of dsRNA in the gut, highlighting a potential target for improving RNAi strategies in managing insect pests like N. lugens.
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Genetic lineage tracing has been widely employed to investigate cell lineages and fate. However, conventional reporting systems often label the entire cytoplasm, making it challenging to discern cell boundaries. Additionally, single Cre-loxP recombination systems have limitations in tracing specific cell populations.

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Background: The incidence rate of duodenal neuroendocrine tumors has been increasing in recent years. Endoscopic resection [ER; endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD)] is recommended for nonampullary duodenal neuroendocrine tumors (NAD-NETs) ≤10 mm in diameter that are confined to the submucosal layer and without lymph node or distant metastasis. However, the efficacy and safety of and indications for EMR/ESD remain unclear.

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The main rice planting areas in the middle and lower reaches of the Yangtze River are primarily affected by two types of rice seedling diseases: bakanae disease and seedling rot disease. These diseases lead to considerable losses. Seed coating technology effectively protects rice from these diseases and mitigates environmental pollution.

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Lambda-cyhalothrin, a representative pyrethroid insecticide widely used for Spodoptera frugiperda control in China, poses challenges due to the development of resistance. This study investigates the realized heritability, inheritance pattern, cross-resistance, and resistance mechanisms to lambda-cyhalothrin. After 21 generations of selection, the lambda-cyhalothrin-resistant strain (G21) developed a 171.

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In this study, an α-amylase-responsive controlled-release formulation was developed by capping polydopamine onto β-cyclodextrin-modified abamectin-loaded hollow mesoporous silica nanoparticles. The prepared Aba@HMS@CD@PDA were subjected to characterization using various analytical techniques. The findings revealed that Aba@HMS@CD@PDA, featuring a loading rate of 18.

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Unlocking the full potential of mRNA immunotherapy necessitates targeted delivery to specific cell subsets in the spleen. Four-component lipid nanoparticles (LNPs) utilized in numerous clinical trials are primarily limited in hepatocyte and muscular targeting, highlighting the imperative demand for targeted and simplified non-liver mRNA delivery systems. Herein, we report the rational design of one-component ionizable cationic lipids to selectively deliver mRNA to the spleen and T cells with high efficacy.

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Background: The personalized treatments of T1 colorectal cancer (CRC) remains controversial. We compared the long-term outcomes of T1 CRC patients after endoscopic resection (ER) and surgery, and evaluated the risk factors for the long-term prognosis.

Methods: T1 CRCs after resection at the Cancer Hospital, Chines Academy of Medical Sciences from June 2011 to November 2021 were reviewed.

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Chlorogenic acid (CGA) and flavonoids are important secondary metabolites, which modulate plant growth and development, and contribute to plant resistance to various environmental stresses. ERF4 has been shown to be a repressor of anthocyanin accumulation in grape, but its full roles in regulating the biosynthesis of other phenylpropanoid compounds still needs to be further studied. In the present study, two NtERF4 genes were identified from N.

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Nucleic acid therapeutics have demonstrated substantial potential in combating various diseases. However, challenges persist, particularly in the delivery of multifunctional nucleic acids. To address this issue, numerous gene delivery vectors have been developed to fully unlock the potential of gene therapy.

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Extremely inefficient utilization of pesticides has prompted a study of low-cost, sustainable, and smart application systems. Herein, as a promising pesticide nanocarrier, hollow mesoporous organosilica nanoparticles (HMONs) were first synthesized by using inexpensive CaCO nanoparticles as the hollow templates. A redox/near-infrared light dual-triggered pesticide release system was further achieved via loading avermectin (AVM) into the HMONs and coating a layer of polydopamine (PDA).

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