Multiple functions of the ALT favorite helicase, BLM.

Eukaryotic somatic cells undergo continuous telomere shortening because of end-replication problems. Approximately 10%~15% of human cancers rely on alternative lengthening of telomeres (ALT) to overcome telomere shortening. ALT cells are characterized by persistent telomere DNA replication stress and rely on recombination-based DNA repair pathways for telomere elongation.

Numerical Study of Thin-Walled Polymer Composite Part Quality When Manufactured Using Vacuum Infusion with Various External Pressure Controls.

The article presents the results of modeling various modes of vacuum infusion molding of thin-walled polymer-composite structures of arbitrary geometry. The small thickness of the manufactured structures and the fixation of their back surface on the rigid surface of the mold made it possible to significantly simplify the process model, which takes into account the propagation of a thermosetting resin with changing rheology in a compressible porous preform of complex 3D geometry, as well as changes in boundary conditions at the injection and vacuum ports during the post-infusion molding stage. In the four modes of vacuum-infusion molding studied at the post-infusion stage, the start time, duration and magnitude of additional pressure on the open surface of the preform and in its vacuum port, as well as the state of the injection gates, were controlled (open-closed).

[Effects of fertilization and planting patterns on soil aggregate and carbon distribution in farmland of the Loess Plateau, Northwest China].

Based on a long-term experiment in the Changwu Agro-ecological Experimental Station in Xianyang, Shaanxi, China, we examined the effects of fertilization and planting patterns on soil aggregate quantity, aggregate stability and total carbon and organic carbon distribution in different aggregate fractions through dry and wet sieving methods, as well as the TOC combustion method. There were ten treatments, including uncultivated (R), wheat continuous cropping (CK/W), wheat-corn rotation (L), and nitrogen fertilizer (N), phosphorus fertilizer (P), nitrogen and phosphorus fertilizer (NP), organic fertilizer (M), nitrogen and organic fertilizer (NM), phosphorus and organic fertilizer (PM), nitrogen and phosphorus and organic fertilizer (NPM) for CK/W. The results showed that fertilizer application and planting patterns affected soil aggregate distribution and stability, the contents and contribution rates of total C and organic C.

ETS1-activated SNHG10 exerts oncogenic functions in glioma via targeting miR-532-3p/FBXL19 axis.

Background: In past few years, long non-coding RNAs (lncRNAs) have been reported to play regulatory roles during cancer progression. LncRNA SNHG10 has been explored in several sorts of cancers. However, its detailed role and mechanism are still not well understood in glioma.

Dried salted plum consumption ameliorates hyperbaric oxygen therapy-induced otalgia severity at the first chamber session: a prospective randomized controlled study.

Purpose: One of the most common complications of hyperbaric oxygen (HBO₂) therapy is middle ear barotrauma (MEB), occasionally causing otalgia. The objective of this study was to evaluate the effect of dried salted plum consumption on MEB and otalgia associated with HBO₂ therapy.

Materials And Methods: Patients undergoing the first chamber session of HBO₂ therapy were included in the present prospective randomized controlled trial.

Epigenetic signatures may explain the relationship between socioeconomic position and risk of mental illness: preliminary findings from an urban community-based sample.

Low socioeconomic position (SEP) has previously been linked to a number of negative health indicators, including poor mental health. The biologic mechanisms linking SEP and mental health remain poorly understood. Recent work suggests that social exposures influence DNA methylation in a manner salient to mental health.

Effect of biomass open burning on particulate matter and polycyclic aromatic hydrocarbon concentration levels and PAH dry deposition in ambient air.

The objectives of the present study were to investigate particulate matter (PM) and polycyclic aromatic hydrocarbon (PAH) concentrations in ambient air during rice straw open burning and non-open burning periods. In the ambient air of a rice field, the mean PM concentration during and after an open burning event were 1828 and 102 μg m⁻³, respectively, which demonstrates that during a rice field open burning event, the PM concentration in the ambient air of rice field is over 17 times higher than that of the non-open burning period. During an open burning event, the mean total PAH and total toxic equivalence (BaP(eq)) concentrations in the ambient air of a rice field were 7206 ng m⁻³ and 10.

Topoisomerase II alpha expression and the benefit of adjuvant chemotherapy for postoperative patients with non-small cell lung cancer.

Background: Adjuvant chemotherapy has been shown to improve survival rates of postoperative patients with non-small cell lung cancer (NSCLC). Biomarkers could help select an appropriate chemotherapy for NSCLC patients or predict the efficacy of chemotherapy. The objective of this study was to explore the possible prognostic and predictive role of topoisomerase II alpha (TopIIα) expression level in postoperative NSCLC patients who received adjuvant chemotherapy.

Complex segregation and linkage analysis of familial gout in Taiwanese aborigines.

Objective: The prevalence of gout and hyperuricemia in Taiwanese aborigines is remarkably high. Although previous studies have failed to find evidence of a major gene responsible for gout, the disease is thought to involve genetic predisposition. We sought to determine whether genetic factors for familial gout exist among Taiwanese aborigines, and, if so, their chromosomal location.

High prevalence of hyperuricemia in adolescent Taiwan aborigines.

Objective: To explore the prevalence and related factors of hyperuricemia among adolescent Taiwan aborigines in tribes with a high prevalence of adult gout, compared with adolescents of low prevalence aboriginal and non-aboriginal tribes.

Methods: The participants were aborigines and non-aborigines in Taiwan, age 12 to 15 years and free of gout. Each participant provided information on sex, age, and parents' tribal background as well as body weight and height.