Structure-guided design of potent JAK1-selective inhibitors based on 4-amino-7H-pyrrolo[2,3-d]pyrimidine with anti-inflammatory efficacy.

In a continuous effort to develop Janus kinase 1 (JAK1)-selective inhibitors, a novel series of 4-amino-7H-pyrrolo[2,3-d]pyrimidine derivatives bearing the piperidinyl fragment were designed and synthesized according to a combination strategy. Through enzymatic assessments, the superior compound 12a with an IC value of 12.6 nM against JAK1 was identified and a 10.

Electrolyte effect for carbon dioxide reduction reaction on copper electrode interface: A DFT prediction.

An insightful understanding of the interaction between the electrolyte and reaction intermediate and how promotion reaction occurs of electrolyte is challenging in the electrocatalysis reaction. Herein, theoretical calculations are used to investigate the reaction mechanism of CO reduction reaction to CO with different electrolytes at the Cu(111) surface. By analyzing the charge distribution of the chemisorbed CO (CO ) formation process, we find that the charge transfer is from metal electrode transfer to CO and the hydrogen bond interaction between electrolytes and CO not only plays a key role in the stabilization of CO structure but also reduces the formation energy of *COOH.

Enhancement of Impact Abrasion Resistance Performances of White Cast Iron Utilizing TiAlC.

Al-Ti-C master alloy agent is currently the most promising grain refiner. This work investigates the influence of TiAlC addition (1.0-3.

Ultrathin Ce-doped LaOnanofilm electrocatalysts for efficient oxygen evolution reactions.

It is still highly desired to develop efficient, resource-abundant and inexpensive electrocatalysts to improve the sluggish kinetics of oxygen evolution reaction (OER) in electrochemical water splitting systems. In this work, the large-area ultrathin (2.52 nm thick) Ce-doped LaOnanofilms were developed via a facile and reliable ionic layer epitaxy method with different Ce content.

Creating Fluorine-Doped MoS Edge Electrodes with Enhanced Hydrogen Evolution Activity.

The edge sites of MoS are catalytically active for hydrogen evolution reactions (HER). However, pristine edge sites usually contain only intrinsic atoms or defects, limiting the tuning of on-site hydrogen species adsorption and desorption, the critical steps for HER. In addition, the number of atoms on pristine edges is small compared to that of electrochemically inert atoms in bulk.

Mesoporous Ultrathin InO Nanosheet Cocatalysts on a Silicon Nanowire Photoanode for Efficient Photoelectrochemical Water Splitting.

Vertical Si nanowire (NW) arrays are a promising photoanode material in the photoelectrochemical (PEC) water splitting field because of their highly efficient light absorption capability and large surface areas for PEC reactions. However, Si NW arrays always suffer from high overpotential, low photocurrent density, and low applied bias photon-to-current efficiency (ABPE) due to their low surface catalytic activity and intense charge recombination. Here, we report an efficient oxygen evolution cocatalyst of optically transparent, mesoporous ultrathin (2.