Publications by authors named "Shumin Gu"
This research aimed to analyze the volatile compounds emitted during the proliferation of Klebsiella pneumoniae (K. pneumoniae) in the laboratory setting using gas chromatography-ion mobility spectrometry (GC-IMS) and to investigate the potential of volatile metabolomics for detecting carbapenemase-producing strains of K. pneumoniae.
View Article and Find Full Text PDFObjective: This research aimed to investigate the variations in clinical features and prognosis of HABP caused by and . We also aimed to evaluate the risk variables related to 30-day death in the investigated groups.
Methods: A single-center retrospective cohort research lasting four years was performed.
BACKGROUND Lactate/albumin (LA/ALB) and procalcitonin/albumin (PCT/ALB) ratios have been implicated in predicting mortality in sepsis patients. However, their prognostic value and relationship to sepsis severity require further investigation. This retrospective study aimed to assess the prognostic value of lactate/albumin (LA/ALB) and procalcitonin/albumin (PCT/ALB) ratios in septic patients admitted to the Intensive Care Unit (ICU).
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- The study looked at two types of treatments for people with a serious infection caused by superbugs at a Chinese hospital.
- It found that patients treated with newer medications (CPT) were in worse overall health but had better recovery rates compared to those receiving traditional treatments (CT).
- Additionally, cold weather was linked to higher chances of dying within 30 days, while the infection was more common in hot weather, suggesting more research is needed.
Article Synopsis
- The study aimed to identify clinical features, risk factors, and effective treatments for Carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infections (BSI) based on data from a Chinese hospital.
- Among 276 patients, 157 had CRAB BSI, with key risk factors including ICU stays, immunocompromised status, and certain antibiotic use.
- The 30-day mortality rate for CRAB BSI was nearly 50%, with cefoperazone/sulbactam treatment showing a significant reduction in mortality compared to other antibiotic strategies.
Background: Carbapenemase-producing is an unprecedented threat to public health, and its detection remains challenging. Analysis of microbial volatile organic compounds (VOCs) may offer a rapid way to determine bacterial antibiotic susceptibility.
Purpose: The aim of this study was to explore the VOCs released by carbapenemase-producing carbapenem-resistant (CRKP) using headspace solid-phase microextraction/gas chromatography-mass spectrometry (HS-SPME/GC-MS).
Article Synopsis
- * Whole-genome sequencing revealed distinct genetic profiles, identifying 20 types of MRSA, with ST59 being the most prevalent, while ST188 and ST7 were predominant in MSSA.
- * The findings indicate that MSSA carries a variety of virulence factors, highlighting the need for increased focus on MSSA infections, and future research should explore the co-evolution of both strains to better understand their interactions.
Emerging evidence indicates that the long noncoding RNA UCA1 is upregulated in multiple cancers, including pancreatic ductal adenocarcinoma (PDAC), and plays a critical role in various complex biological processes. However, the functional roles of UCA1 in PDAC remain to be clarified. In the current study, we showed that UCA1 significantly promoted cell proliferation and tumor growth both in vitro and in vivo, and enhanced stemness maintenance of PDAC cell lines.
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