Publications by authors named "Shumin Chen"

is a major threat to both human and animal health. However, the diversity and antibiotic resistance of animal-derived and their association with human infections remain largely unexplored. In this study, strains were isolated, identified, and sequenced from dead embryos and cloacal swab samples obtained from 278 large-scale duck farms in 11 cities in Shandong Province.

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The Solanaceae family contains many agriculturally important crops, including tomato, potato, pepper, and tobacco, as well as others with growing potential, such as the orphan crops groundcherry, wolfberry, and pepino. Research progress varies greatly among these species, with model crops like tomato far ahead, which limits the broader agricultural application of other solanaceous species. Here, we constructed the interspecies pan-genome for the Solanaceae family and identified distinct patterns of gene retention.

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In B cells, the chemokine receptor CXCR3 is expressed only by a subset of B cells. However, CXCR3 is highly expressed in a rare type of B-cell lymphoma known as Mantle Cell Lymphoma (MCL) and CXCR3 inhibitor impairs proliferation and induces apoptosis in the MCL cell line JeKo-1. Despite this, the mechanism responsible for maintaining high levels of CXCR3 in MCL cells remains unclear.

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Influenza poses a significant threat to the global economy and health. Inactivated virus vaccines were introduced in China for prevention in 2018. In this study, three pairs of hemagglutinin (HA) and neuraminidase (NA) gene sequences were obtained from three Swine influenza virus (IAV-S) inactivated vaccine strains that were marketed in China in 2018.

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Article Synopsis
  • PET waste is tough to break down and poses environmental issues, but upcycling it into valuable chemicals can help solve this problem and support a circular economy.
  • A study developed a multi-enzyme system in E. coli to convert terephthalic acid, derived from PET, into vanillin, achieving high production levels through metabolic engineering.
  • The engineered E. coli efficiently converted post-consumer PET waste into vanillin, demonstrating an eco-friendly method that also turns low-value waste into profitable products.
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The paper interprets the formulation, main content and characteristics of issued by World Federation of Acupuncture Societies (WFAS 007.2-2023, short for Guideline). The Guideline focuses on the clinical value of acupuncture regimen for smoking cessation and its abstinence rate, and attaches the importance to the actual needs of patients, the counseling and management of smoking cessation.

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Background: Cabbage Fusarium wilt (CFW) is a devastating disease caused by the soil-borne fungus Fusarium oxysporum f. sp. conglutinans (Foc).

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  • Polyploidization is vital for plant evolution and breeding, with synthetic polyploids showing significant structural variations and epigenetic changes.
  • This study explored genome-wide deletions/duplications (DelDups) and methylation dynamics in synthetic tetraploids from Chinese cabbage and cabbage over eight generations.
  • Key results indicate that larger genomic regions lead to more frequent DelDups, with gene expression influenced by the number of genomic copies, and that methylation changes do not widely affect gene expression.
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  • Deep learning techniques were used to explore subgenome dominance, which is the preferential expression of genes in one of the two genomes in allopolyploid plants, influencing their evolution.
  • The study developed two convolutional neural network models—binary expression model (BEM) and homoeolog contrast model (HCM)—to analyze the relationship between DNA sequences, methylation sites, and gene expression in three plant systems: Brassica, Gossypium, and Cucurbitaceae.
  • The findings suggest that long-term sequence differences in gene promoter regions drive subgenome dominance, indicating that this dominance is a key factor in genetic evolution post-polyploidization.
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Aim: Patients with acute ischaemic stroke are more likely to develop refeeding syndrome due to increased need for nutritional support when suffering alterations of consciousness and impairment of swallowing. This study aimed to evaluate the incidence, risk factors and outcomes of refeeding syndrome in stroke patients.

Methods: This was a retrospective observational study, using the prospective stroke database from hospital, included all consecutive acute ischaemic stroke patients who received enteral nutrition for more than 72 h from 1 January 2020 and 31 December 2022.

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Introduction: Peripheral vascular atherosclerosis (PVA) is a chronic inflammatory disease characterized by lipid accumulation in blood vessel walls, leading to vessel narrowing and inadequate blood supply. However, the molecular mechanisms underlying PVA remain poorly understood. In this study, we employed a combination of Mendelian randomization (MR) analysis and integrated transcriptomics to identify the critical gene signature associated with PVA.

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Handgrip strength is a crucial indicator to monitor the change of cognitive function over time, but its mechanism still needs to be further explored. We sampled 59 monozygotic twin pairs to explore the potential mediating effect of DNA methylation (DNAm) on the association between handgrip strength and cognitive function. The initial step was the implementation of an epigenome-wide association analysis (EWAS) in the study participants, with the aim of identifying DNAm variations that are associated with handgrip strength.

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The destruction of the microvascular structure and function can seriously affect the survival and prognosis of patients with acute myocardial infarction (AMI). Nuciferine has a potentially beneficial effect in the treatment of cardiovascular disease, albeit its role in microvascular structure and function during AMI remains unclear. This study aimed to investigate the protective effect and the related mechanisms of nuciferine in microvascular injury during AMI.

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Constructing inbred lines for self-incompatible species and species with long generation times is challenging, making the use of F outcross/segregating populations the main strategy for genetic studies of such species. However, there is a lack of dedicated algorithms/tools for rapid quantitative trait locus (QTL) mapping using the F populations. To this end, we have designed and developed an algorithm/tool called OcBSA specifically for QTL mapping of F populations.

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Brassica oleracea, globally cultivated for its vegetable crops, consists of very diverse morphotypes, characterized by specialized enlarged organs as harvested products. This makes B. oleracea an ideal model for studying rapid evolution and domestication.

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Objective: Cynarin is a derivative of hydroxycinnamic acid presented in various medicinal plants, such as L. and L. To date, the antioxidant and antihypertensive activities of cynarin have been reported.

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Polyploidization is important to the evolution of plants. Subgenome dominance is a distinct phenomenon associated with most allopolyploids. A gene on the dominant subgenome tends to express to higher RNA levels in all organs as compared to the expression of its syntenic paralogue (homoeolog).

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Objective: Zishen Yutai Pill (ZYP) is a frequently used traditional Chinese medicine (TCM) preparation in women's health. However, the effects of ZYP on endometrial epithelial response have not been fully explored. Herein, uterine natural killer cell (uNK) secretion medium was used to mimic the uterine microenvironment.

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The relationships between mixtures of multiple minerals and depression have not been explored. Therefore, we analyzed the relationship between the mixture of nine dietary minerals [calcium (Ca), phosphorus, magnesium (Mg), iron (Fe), zinc, copper (Cu), sodium, potassium (K), and selenium (Se)] and depressive symptoms in the general population. We screened 20,342 participants from the National Health and Nutrition Examination Survey (NHANES) 2007-2018.

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Aims/introduction: Fibrosis is the principle reason for heart failure in diabetes. Regarding the involvement of long non-coding ribonucleic acid zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) in diabetic myocardial fibrosis, we explored its specific mechanism.

Materials And Methods: Human cardiac fibroblasts (HCF) were treated with high glucose (HG) and manipulated with plasmid cloning deoxyribonucleic acid 3.

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Objective: To systematically review the efficacy of acupuncture for the treatment of tobacco withdrawal syndrome.

Methods: The randomized controlled trials (RCTs) regarding acupuncture for treatment of tobacco withdrawal syndrome were searched in CNKI, Wanfang, VIP, SinoMed, PubMed, Cochrane, Medline and EMbase databases. The search period was from January 1st of 2011 to December 31st of 2021.

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Handgrip strength has been shown an indispensable biomarker for older adults. Furthermore, the association between sleep duration and grip strength in special populations (e.g.

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Article Synopsis
  • The study explores how the intestinal microbes of Beagle dogs differ between specific pathogen-free (SPF) and non-SPF environments, focusing on the diversity of gut bacteria across different ages.
  • Analysis revealed that non-SPF Beagles host a more complex gut microbiota at birth, which declines with age, while SPF Beagles show an increase in microbial diversity as they grow.
  • The research highlights the presence of anti-inflammatory bacteria in non-SPF Beagles, suggesting these microbes help them adapt better to diverse environments compared to the more sensitive gut microbiota of SPF Beagles.
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