[Arbidol used in the prophylaxis of acute respiratory viral infections and their complications in servicemen].

The prophylactic action of arbidol to prevent the acute respiratory viral infections and their complications (extra-hospital pneumonia) was studied under conditions of two military collectives during winter and summer time. The data obtained confirm the prophylactic activity of the drug in respect of ARVI. Regardless of the degree of disease epidemic rise among the servicemen who didn't take arbitol the minimal threshold of grippe and other ARVI incidence (10-15%) remained in the experimental group.

[Efficacy of arbidol in prophylaxis and treatment of acute respiratory viral infections in servicemen].

The authors present the results of study of arbidolum therapeutic-and-prophylactic effectiveness in acute respiratory viral infections (ARVI) under conditions of military staff with determination of economic expediency. Coefficient of effectiveness of arbidolum prophylactic use was 25% and efficiency index--1.33.

[Experience in studying antigenic activity of inactivated hepatitis A vaccine].

The results obtained during the study of antigeneity of inactivated vaccines against hepatitis A ("Avaxim", France; "Hep-A-in-VAC", Russia; "Havrix", Belgium) used in troop units and RF MD institutions are presented in the article. The aim of the investigation is choice of the drug that provides the production of antibody protective levels in maximally short periods. It is very important for the army collectives sent to the zones of armed conflicts and HAV epidemic centres.

[Epidemiologic effectivness of poludane in preventing influenza and other acute respiratory diseases in troops].

The epidemiological effectiveness of interferon inductor "Poludanum" produced by "LENS Pharm" (Russia) for prevention of acute respiratory viral infections was tested. The drug was administered among the students of Military Medical Academy (101 students) according to scheme 1: in a nose, 3 drops in each nasal passage two times per week during 4 weeks, with 2 week interruption then the scheme was repeated. The scheme 2 included 3 drops in each nasal passage once a week during 10 weeks (95 students).

[An improvement in the demonstration of the causative agents of dangerous infections under the conditions of local wars and armed conflicts].

The system of the specific indication of the causative agents of infectious diseases, accepted in the Armed Forces of the Russian Federation (RF) in piece and wartime and based on the study of specimens by stages in laboratories of the sanitary epidemiological institutions of the Ministry of Defense of the RF, is presented. This system is insufficiently adapted to the conditions of local wars (LW) and armed conflicts (AC). Under these conditions, it is expedient to carry out the specific indication of infective agents not by stages, but completely (according to an enlarged scheme), replenishing the medical service of the field forces with specialists, transferred from higher sanitary epidemiological institutions.

[Decreased capacity of the peripheral blood lymphocytes for excisional DNA repair in disseminated sclerosis].

In patients with multiple sclerosis the reduction of DNA excision reparation capacity of peripheral blood lymphocytes was found to correlate with the disease severity but not with its duration. These changes and the increase in the DNA reparative synthesis along with the lymphocytes DNA structural changes are considered as the evidence of impaired lymphocytes genome stability in this ailment. Their possible role in the development of immunodeficiency in multiple sclerosis is discussed.

[The SOS and catabolytic repression systems can play a key role in the regulation of infection of Escherichia coli cells with F-specific filamentous phages M13, f1 and fd].

Theoretical analysis of DNA sequences revealed recognition sites for two global E. coli cellular regulons in M13, fd and fl phage's genomes. Both Px and Pv promoters have SOS operator sequences and therefore must be repressed by the lexA protein.

[Minor promoters of phage phi X174 are controlled by CRP-cAMP, lexA, glnG and several other common common regulatory systems of the host cell].

It was found that CRP-cAMP-recognized sequences in DNA being suggested as GTGN7-11CAC (with variability both in domain's structures and in spacer's length) are located non-randomly in promoters. In CRP-cAMP-stimulated promoters they lie upstream the "-35" box and are separated from it by a whole number of DNA turns, whereas in CRP-cAMP-repressed ones they are located downstream "-35" in a half-whole-turn-number distance. Several CRP-, SOS- and NR1-sites in the phi X174 DNA sequence were found and a few new promoters were deduced from it.

[Periodic classification of DNA sequences recognized by restrictases: properties of symmetry and regularity].

A circular periodic map of short palindromic DNA sequences is constructed using the sequence homology and symmetry. It is applied to compare sequences recognised by class II restriction and modification enzymes with other similar DNA sequences. All known restriction sites have two strong properties: they are enriched by GC pairs, and clustered (purine-purine, pyrimidine-pyrimidine) bonds predominant upon alternating ones.

[Protection of segments of replicative form I of phiX174 phage DNA recognized by HindII, BspRI, and AluI restrictases by Escherichia coli RNA-polymerase].

The preincubation of a DNA with E. coli RNA polymerase provides its partial protection against the HindII, BspRI and AluI cleavage giving possibility to determine the location of RNA polymerase tight-binding sites. Using this approach about 16 RNA polymerase tight-binding sites were detected on replicative form of phiX174 phage DNA.

[Encephalopathic syndrome in chronic non-specific lung diseases].

On the basis of a clinical, laboratory (blood gas content, function of external respiration, EEG, ECG eye ground, etc.) and pathomorphological studies the authors describe a syndrome of chronic lung encephalopathy in 34 patients with chronic nonspecific lung diseases (chronic pneumonia, chronic bronchitis). The report contains data on the development of chronic encephalopathy depending upon the severity of the basic disease.