[Resistant epileptic encephalopathy in a child with microcephalic capillary malformation syndrome].

Treatment resistant epileptic encephalopathy (EE) in childhood in a significant amount due to genetic damage or congenital abnormalities of the brain. The literature described a rare microcephalic-capillary malformation syndrome (Microcephaly-capillary malformation, MIC-CAP), manifested from the first month of life by the early onset of treatment-resistant epilepsy, severe progressive microcephaly, spastic tetraparesis, severe delay in psychomotor development, multiple, small-sized capillary angiomas on the body and underdevelopment of the fingers. The boy was diagnosed with a previously described variant of the nucleotide sequence in exon 2 of the chr2 gene:74058171rs781694797 188A>G in the homozygous state, leading to the replacement of the amino acid p.

[The administration of neurocytoprotectors in a rat model of experimental spinal cord ischemia].

Aim: To study an effect of cortexin on functional recovery and morphology of the spinal cord of rats with spinal cord ischemia.

Material And Methods: Spinal cord ischemia was achieved by ligation of the infrarenal abdominal aorta in 16 rats stratified into two equal groups: the ligation of infrarenal aorta was performed in the control group, aorta ligation was performed also in the experimental group with preliminary intraperitoneally administration of cortexin in a dose of 0.15 mg/kg 30 min before procedure.