Hub genes, diagnostic model, and predicted drugs related to ferroptosis in chronic rhinosinusitis with nasal polyps.

Significant progress has been made in the pathogenesis of chronic rhinosinusitis (CRS). However, the relationship between chronic rhinosinusitis with nasal polyps (CRSwNP) and ferroptosis, as well as its underlying molecular mechanism, remains unclear. This study aimed to investigate the correlation between CRSwNP and ferroptosis and identify key gene associated with ferroptosis that could impact the diagnosis and treatment of CRS.

Dynamic Nonlinear Spatial Integrations on Encoding Contrasting Stimuli of Tectal Neurons.

Animals detect targets using a variety of visual cues, with the visual salience of these cues determining which environmental features receive priority attention and further processing. Surround modulation plays a crucial role in generating visual saliency, which has been extensively studied in avian tectal neurons. Recent work has reported that the suppression of tectal neurons induced by motion contrasting stimulus is stronger than that by luminance contrasting stimulus.

Clopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke: The ATAMIS Randomized Clinical Trial.

Importance: Dual antiplatelet therapy has been demonstrated to be superior to single antiplatelet in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect in patients with mild to moderate ischemic stroke is lacking.

Objective: To evaluate whether dual antiplatelet therapy is superior to single antiplatelet among patients with mild to moderate ischemic stroke.

Design, Setting, And Participants: This was a multicenter, open-label, blinded end point, randomized clinical trial conducted at 66 hospitals in China from December 20, 2016, through August 9, 2022.

Gamma-band-based dynamic functional connectivity in pigeon entopallium during sample presentation in a delayed color matching task.

Birds have developed visual cognitions, especially in discriminating colors due to their four types of cones in the retina. The entopallium of birds is thought to be involved in the processing of color information during visual cognition. However, there is a lack of understanding about how functional connectivity in the entopallium region of birds changes during color cognition, which is related to various input colors.

Correction to: Gamma-band-based dynamic functional connectivity in pigeon entopallium during sample presentation in a delayed color matching task.

[This corrects the article DOI: 10.1007/s11571-022-09916-w.].

Corrigendum: inhibits induced mucosal barrier disruption.

[This corrects the article DOI: 10.3389/fmicb.2022.

Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial.

Importance: Intravenous thrombolysis is increasingly used in patients with minor stroke, but its benefit in patients with minor nondisabling stroke is unknown.

Objective: To investigate whether dual antiplatelet therapy (DAPT) is noninferior to intravenous thrombolysis among patients with minor nondisabling acute ischemic stroke.

Design, Setting, And Participants: This multicenter, open-label, blinded end point, noninferiority randomized clinical trial included 760 patients with acute minor nondisabling stroke (National Institutes of Health Stroke Scale [NIHSS] score ≤5, with ≤1 point on the NIHSS in several key single-item scores; scale range, 0-42).

Correlation between Pneumatization Variants of Paranasal Sinuses and Skull Base and Spontaneous Cerebrospinal Fluid Rhinorrhea: A Case-Control Study.

Introduction: Spontaneous cerebrospinal fluid rhinorrhea (SCSFR) is the most common type of cerebrospinal fluid leakage and may cause serious cerebral complications. The aim of this research was to investigate the relationship between the degree of pneumatization variants of the paranasal sinus and skull base and the incidence of SCSFR.

Methods: In total, 131 patients with SCSFR were analyzed, and 50 patients suffering from the nasal septal deviation were selected as controls.

Detection of a temporal salient object benefits from visual stimulus-specific adaptation in avian midbrain inhibitory nucleus.

Food and predators are the most noteworthy objects for the basic survival of wild animals, and both are often deviant in both spatial and temporal domains and quickly attract an animal's attention. Although stimulus-specific adaptation (SSA) is considered a potential neural basis of salient sound detection in the temporal domain, related research on visual SSA is limited and its relationship with temporal saliency is uncertain. The avian nucleus isthmi pars magnocellularis (Imc), which is central to midbrain selective attention network, is an ideal site to investigate the neural correlate of visual SSA and detection of a salient object in the time domain.

inhibits induced mucosal barrier disruption.

Background: () is a common nasal colonizer, whereas () is typically regarded a pathogenic organism in patients with chronic rhinosinusitis (CRS). This study aims to evaluate the interaction of the two bacteria .

Methods: Clinical isolates of and from sinonasal swabs, as well as primary human nasal epithelial cells (HNECs) cultured from cellular brushings of both healthy and CRS patients were used for this study.

Visual Responses to Moving and Flashed Stimuli of Neurons in Domestic Pigeon () Optic Tectum.

Birds can rapidly and accurately detect moving objects for better survival in complex environments. This visual ability may be attributed to the response properties of neurons in the optic tectum. However, it is unknown how neurons in the optic tectum respond differently to moving objects compared to static ones.

Surround Modulation Properties of Tectal Neurons in Pigeons Characterized by Moving and Flashed Stimuli.

Surround modulation has been abundantly studied in several mammalian brain areas, including the primary visual cortex, lateral geniculate nucleus, and superior colliculus (SC), but systematic analysis is lacking in the avian optic tectum (OT, homologous to mammal SC). Here, multi-units were recorded from pigeon () OT, and responses to different sizes of moving, flashed squares, and bars were compared. The statistical results showed that most tectal neurons presented suppressed responses to larger stimuli in both moving and flashed paradigms, and suppression induced by flashed squares was comparable with moving ones when the stimuli center crossed the near classical receptive field (CRF) center, which corresponded to the full surrounding condition.

ISMN-loaded PLGA-PEG nanoparticles conjugated with anti- α-toxin inhibit biofilms in chronic rhinosinusitis.

biofilms were linked to negative postsurgical outcomes of chronic rhinosinusitis (CRS). This study aims to develop a targeted nanoparticle and characterize its bactericidal effects. The authors prepared ISMN-loaded poly-lactide-co-glycolide acid (PLGA) and polyethylene glycol (PEG) nanoparticles conjugated with anti- α-toxin (AA; ISMN-PLGA-PEG-AA), and determined its bactericidal and toxic effects.

Long non-coding RNA nuclear paraspeckle assembly transcript 1 promotes activation of T helper 2 cells via inhibiting STAT6 ubiquitination.

T helper (Th) 2 cell-medicated immune response participates in various immune diseases, including systemic lupus erythematosus (SLE). Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported to be associated with T helper 2 (Th2) cell activation. Here, we demonstrated the molecular mechanism of NEAT1 in regulating Th2 cell activation.

Comparison of pop-out responses to luminance and motion contrasting stimuli of tectal neurons in pigeons.

The emergence of visual saliency has been widely studied in the primary visual cortex and the superior colliculus (SC) in mammals. There are fewer studies on the pop-out response to motion direction contrasting stimuli taken in the optic tectum (OT, homologous to mammalian SC), and these are mainly of owls and fish. To our knowledge the influence of spatial luminance has not been reported.

Assessment of three types of intranasal nebulization devices in three-dimensional printed models and volunteers: a pilot study.

Background: Intranasal nebulization is an effective treatment for chronic rhinosinusitis and allergic rhinitis; however, terminal inhalation devices have not been fully studied. We compared the sinonasal aerosol distributions and adverse effects of different inhalation units.

Methods: A mask, double-head nozzle, and single-head nozzle were applied to atomize the methylene blue solution to 3-dimensional printed models of the pediatric nasal cavity, adult nasal cavity with septal deviation, and postsurgical paranasal sinuses, and staining of the different sites was scored.

Inhibition of and biofilms by quatsomes in low concentrations.

Unlabelled: and are primary pathogens in chronic rhinosinusitis (CRS), and the presence of and biofilms has been associated with negative outcomes after surgery. This study investigated the inhibition effect of cetylpyridinium chloride (CPC)-quatsomes at low concentrations on both and biofilms , as well as their toxicities towards cultured human airway epithelial (NuLi-1) cells. ATCC 25923 and ATCC 15692 were used to establish biofilms.

Creation and validation of three-dimensional printed models for basic nasal endoscopic training.

Background: Three-dimensional (3D) printed models have been shown to be promising in surgical training in rhinology. The objectives of this study were to develop a set of 3D-printed models including the pediatric and adult nasal cavity, and the postsurgical paranasal sinuses, and to assess the face and content validity in endoscopic training.

Methods: The computed tomography (CT) data of a pediatric patient without nasal disorders and an adult patient with nasal septal deviation were selected to produce the models of the pediatric and adult nasal cavity, and the CT data of an adult patient who underwent endoscopic sinus surgery 4 months ago was chosen to create the paranasal sinus model.

NEAT1 regulates Th2 cell development by targeting STAT6 for degradation.

The aim of this study was to investigate the role of lncRNA NEAT1 (nuclear enriched abundant transcript 1) in regulating Th2 cell differentiation. The overexpression vectors of NEAT1 and ITCH, and siRNA targeting NEAT1, EZH2 (enhancer of zeste homolog 2) and STAT6 (signal transducer and activator of transcription 6) were transfected into CD4+T cells. The mRNA expressions of ITCH and STAT6 were analyzed by qRT-PCR and western blotting.

Pharmacokinetics and distributions of bevacizumab by intravitreal injection of bevacizumab-PLGA microspheres in rabbits.

Aim: To investigate the pharmacokinetics and distributions of bevacizumab by intravitreal injection of prepared bevacizumab-poly (L-lactic-co-glycolic acid) (PLGA) microspheres in rabbits, to provide evidence for clinical application of this kind of bevacizumab sustained release dosage form.

Methods: Bevacizumab was encapsulated into PLGA microsphere via the solid-in-oil-in-hydrophilic oil (S/O/hO) method. Fifteen healthy New Zealand albino-rabbits were used in experiments.

Lack of association between vitamin D receptor gene FokI and BsmI polymorphisms and prostate cancer risk: an updated meta-analysis involving 21,756 subjects.

The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. The polymorphisms in the VDR gene have been hypothesized to alter the risk of prostate cancer. However, studies investigating the association between VDR polymorphisms (BsmI and FokI) and prostate cancer (PCa) risk report conflicting results , therefore, we conducted a meta-analysis to re-examine the controversy.