Publications by authors named "Shulu Yuan"
Article Synopsis
- COVID-19 may heighten the risk of memory decline and Alzheimer's disease, but direct evidence of its impact on brain changes is still limited.
- A study of postmortem brain samples revealed abnormal levels of hyperphosphorylated tau protein and prolonged glial activation in key brain areas months after COVID-19 recovery, despite no evidence of the virus in those regions.
- While COVID-19 didn't significantly affect beta-amyloid levels or neuron counts, the findings suggest a potential link between post-COVID neurological changes and an increased risk of Alzheimer's disease.
Chronic pain is a significant health problem worldwide. Recent evidence has suggested that the ventral hippocampus is dysfunctional in humans and rodents, with decreased neuronal excitability and connectivity with other brain regions, parallel pain chronicity, and persistent nociceptive hypersensitivity. But the molecular mechanisms underlying hippocampal modulation of pain remain poorly elucidated.
View Article and Find Full Text PDFChronic pain is one of the most significant medical problems throughout the world. Recent evidence has confirmed the hippocampus as an active modulator of pain chronicity, but the underlying mechanisms remain unclear. Using in vivo electrophysiology, we identify a neural ensemble in the ventral hippocampal CA1 (vCA1) that shows inhibitory responses to noxious but not innocuous stimuli.
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