The mevalonate coordinates energy input and cell proliferation.

The mevalonate pathway is known for the synthesis of cholesterol, but recent studies have reported that it also controls Hippo signaling, which is critical for the regulation of organ size and tumorigenesis. Here, we discover that the suppression of the mevalonate pathway inhibits the growth and proliferation of colon cancer cell lines. The results of transcriptomic and proteomic assays suggested that the mevalonate pathway controls multiple signaling pathways relevant to cell proliferation, and the results were further confirmed using western blot, PCR, and immunofluorescence assays.

Horizontal displacement monitoring method of deep foundation pit based on laser image recognition technology.

Currently, inclinometers are often used to monitor the horizontal displacement of deep foundation pits; however, this method generally has a high cost and complex operation and cannot monitor in real time. In this paper, a novel monitoring method for horizontal displacement of deep foundation pits based on laser image recognition technology is proposed. By identifying the displacement of the spot produced by the laser emitter fixed at the monitoring point, the displacement of the deep foundation pit is determined.