Publications by authors named "Shulai Lu"

Objectives: The potential association between oral health and nutritional status of the very old, has been poorly investigated. Thus, we carried out the cross-sectional study to evaluate the association of oral health with the nutritional status of the older adults.

Methods: 210 participants aged over 75 years were included in the study.

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Tooth extraction commonly causes uncontrolled bleeding, loss of blood clots, and bacterial infection, leading to the dry socket and bone resorption. Thus, it is highly attractive to design a bio-multifunctional scaffold with outstanding antimicrobial, hemostatic, and osteogenic performances for avoiding dry sockets in clinical applications. Herein, alginate (AG)/quaternized chitosan (Qch)/diatomite (Di) sponges were fabricated via electrostatic interaction, Ca cross-linking, as well as lyophilization methods.

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Poly--lactic acid (PLLA) is an environmentally friendly and renewable polymer material with excellent prospects, but its low crystallization rate greatly limits its application. Through the amidation reaction between amino hyperbranched polymer (HBP N103) and carboxylated carbon nanotubes (CNTs), CNTs-N103 was obtained. The modification was confirmed by Fourier-transform infrared (FTIR) spectroscopy, X-ray electron spectroscopy (XPS) and thermogravimetric analysis (TGA).

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Tooth removal, particularly for patients with severe periodontitis, can frequently cause massive bleeding, postoperative infection, and bone resorption, resulting in a dry socket. Thus, developing bio-multifunctional materials with excellent antibacterial, hemostatic, and osteogenic characteristics for the prevention of dry sockets after tooth removal is highly desirable in clinical applications. Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic, and osteogenic properties were developed via Ca crosslinking, lyophilization, and electrostatic interaction for the prevention of dry socket after tooth removal.

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Studies have shown that high-density lipoprotein (HDL) is a powerful anti-atherosclerosis factor in vivo and in vitro, with anti-inflammatory effects, and it also plays an important role in the immune system and central nervous system (CNS). In this study, the BV2 microglia inflammation model and experimental autoimmune encephalomyelitis animal model were used to investigate the potential mechanism of HDL in multiple sclerosis. Our results show that HDL inhibits the activation of BV2 microglia in a model of BV2 microglia inflammation and were validated with primary microglia.

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In this manuscript, the graphene oxide (GO) was modified by hyper-branched polyester (HBP). The effects of GO or modified GO (HBP-m-GO) on the mechanical performance and wearing properties were investigated. The results of X-ray photoelectron spectra (XPS), Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM) revealed the successful grafting of HBP onto GO.

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Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa. The prevalence rate of OLP in adults is 0.5%-2%.

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Results: The outbreak of coronavirus disease 2019 (COVID-19) has become a primary challenging public health issue for not only China but also the world. On March 11, 2020, the World Health Organization declared that the pandemic of COVID-19 had become a public health emergency of global concern. As of May 12, 2020 COVID-19 has been reported in over 180 countries/regions, with a total of 4,178,156 confirmed cases and over 280,000 deaths.

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A stabilizer called 2-tert-butyl-6-(3-tert-butyl-2-hydroxy-5-methylbenzyl)-4-methylphenyl acrylate (GM) was mixed in acrylonitrile butadiene styrene (ABS) with the same amount of 9-bis(octadecyloxy)-2,4,8,10-tetraoxa-3,9-diphosphaspiro[5.5]undecane (DSPDP), octadecyl-3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate (Irganox 1076) and tris(3,5-di-tert-butyl-4-hydroxybenzyl) isocyanurate (Irganox 3114) to investigate the influence of additives on the antiaging effect of ABS in oven aging or repeated extrusion aging. It was found that the ABS doped with the GM stabilizer showed a better yellowing resistance and thermal stability than the ABS doped with other antioxidants.

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To explore the anti-atherosclerotic effects of recombinant high-density lipoproteins (rHDL) of apolipoprotein AI wild-type (apoA-Iwt), apolipoprotein AI Milano (apoA-IM), apolipoprotein AI (N74C) (apoA-I (N74C) )and apolipoprotein AV (apoA-V). We constructed rHDL liposomes (rHDLs), which included apoA-Iwt, apoA-IM, and apoA-I (N74C), followed by the synthesis of rHDLs, with the indicated ratios of apoA-Iwt, apoA-IM, apoA-I (N74C) and apoA-V. We investigated the anti-atherosclerotic effects by experiments including the DMPC clearance assay and experiments that assessed the antioxidation against low-density lipoprotein, the cellular uptake of oxidized low-density lipoprotein (oxLDL) and the intracellular lipid accumulation.

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The effects of postharvest trisodium phosphate (TSP) dipping (0.5 mg/mL) on the quality and mitochondrial energy metabolism of apple fruit (cv. Golden delicious) were studied.

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Objective: To investigate the anti-inflammatory effects of high-density lipoprotein (HDL) in mice with rheumatoid arthritis (RA) induced by collagen.

Methods: Male DBA/1 mice (8-week-old) were divided into three groups: control (treated with saline), collagen-induced arthritis (CIA), and CIA + HDL. CIA was induced with bovine type II collagen, and after the injection of bovine type II collagen, the CIA + HDL group received an injection of HDL on day 28 followed by HDL injections four times every 3 days.

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Activating transcription factor 3 (ATF3) is a TLR-induced repressor that plays an important role in the inhibition of specific inflammatory signals. We previously constructed recombinant high density lipoproteins (rHDL) (including rHDL, rHDL, rHDL and rHDL) and found that rHDL had a strong anti-inflammatory ability. In the present study, we investigate the roles of recombinant apolipoprotein A-I (ApoA-I) (rHDL) and its cysteine mutant HDLs (rHDL, rHDL and rHDL) on ATF3 function in RAW264.

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Oral lichen planus (OLP) is one of the most common oral mucosa diseases; however, familial OLP is uncommon. The present study reported and analyzed patients with familial OLP (n=18) in eight different Chinese families between January 1, 2012 and December 31, 2013. Parameters analyzed include gender, age at diagnosis, lesion distribution and lesion type.

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Lipoma is the most common benign tumor that occurs at any region where adipose tissue is present. However, as the tongue is devoid of adipocyte it is an extremely rare site for a lipoma to develop, particularly in China. The present study reports the presence of a tongue lipoma in a 78-year-old man that measured 2.

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Objectives: Periodontal ligament stem cells (PDLSCs) are characterized by having multipotential differentiation and immunoregulatory properties, which are the main mechanisms of PDLSCs-mediated periodontal regeneration. Periodontal or bone regeneration requires coordination of osteoblast and osteoclast, however, very little is known about the interactions between PDLSCs and osteoblast-like cells or osteoclast precursors. In this study, the indirect co-culture approach was introduced to preliminarily elucidate the effects of PDLSCs on differentiation of osteoblast-like cells and osteoclast precursors in vitro.

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Many studies have shown that LPS mainly activates four signal transduction pathways to induce inflammation, namely the p38, ERK1/2, JNK and IKK/NF-κB pathways. Studies have demonstrated that 5'-AMP-induced hypothermia (AIH) exhibits high anti-inflammatory capabilities. In this study, we explore that how AIH inhibits the inflammatory response.

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Objective: To investigate the anatomical features of iliac bone grafts used for mandibular reconstruction and dental implantation.

Methods: Sixteen cadavers were dissected. The length, width, height and cortical thickness of the iliac bone were measured with respect to points determined by the relative dimensions of the bone.

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To investigate whether the hypothermia induced by Adenosine 5'-Monophosphate (5'-AMP) could attenuate early stage injury in a rat acute gouty arthritis model. Ankle joint injection with monosodium urate monohydrate crystals (MSU crystals) in hypothermia rat model which was induced by 5'-AMP and then observe whether hypothermia induced by 5'-AMP could be effectively inhibit the inflammation on acute gouty arthritis in rats. AMP-induced hypothermia has protective effects on our acute gouty arthritis, which was demonstrated by the following criteria: (1) a significant reduction in the ankle swelling (p < 0.

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Our previous studies showed that recombinant high-density lipoprotein (rHDL) rHDL74 exhibited higher anti-inflammatory capabilities compared to wild-type rHDL (rHDLwt), while rHDL228 showed hyper-proinflammation. In this paper, we further investigated the potential mechanisms involved in their different inflammatory functions using two models: endotoxemic mice and the RAW264.7 inflammation model.

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We have built a rat's model to investigate whether the hypothermia induced by adenosine 5'-monophosphate (5'-AMP) (AIH) could attenuate acute lung injury induced by LPS in rats. We detected the inflammatory cytokine levels in the plasma and bronchoalveolar lavage fluid samples, and we analyzed the pathological changes in the lungs. We have found that AIH can effectively inhibit acute inflammatory reactions and protect the lung from acute injury induced by LPS in rats.

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Objective: To determine the anti-inflammatory functions of different cysteine mutants of apolipoprotein A-I recombinant HDLs.

Methods: The recombinant HDLs (named rHDL52, rHDL107, rHDL173, rHDLwt) were reconstituted by mixing wild types or their mutants with dipalmitoyl phosphatidylcholine. And the in vivo effects on lipopolysaccharide (LPS)-induced endotoxemia were examined in mice.

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Article Synopsis
  • The study aimed to explore how different cysteine mutants of apolipoprotein A-I recombinant high-density lipoproteins (rHDLs) help reduce inflammation during endotoxemia in mice.
  • The researchers reconstituted various mutant rHDLs and tested their effects in mice after inducing an inflammatory response with LPS.
  • Results showed that the rHDL74 mutant significantly lowered inflammation markers and protected the lungs from damage, suggesting it could be a promising treatment for septic shock caused by endotoxins.
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Purpose: To study the relationship between ultrasonographic thickness and EMG activity of the masseter muscle in subjects with different vertical craniofacial morphology.

Methods: Thirty female students were separated into two groups (14 cases with high-angle, 16 cases with low-angle) based on SN-MP angle, FH-MP angle, and FHI. The thickness of the masseter muscle under relaxed conditions and during maximal clenching was assessed by ultrasonography.

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Self-stabilized magnetic polymeric composite nanoparticles (SS-MPCPs) were prepared by emulsifier-free miniemulsion polymerization using styrene (St) as a monomer, sodium p-styrenesulfonate (NaSS) as an ionic comonomer, hexadecane (HD) as a hydrophobe, and 2,2'-azodiisobutyronitrile (AIBN) as an initiator in the presence of hydrophobic magnetite particles. The hydrophobic magnetite particles with an average size of about 10 nm were prepared by the acidification of the water-based magnetite ferrofluid, previously synthesized by a chemical coprecipitation method. Some colloidal features of the synthesized SS-MPCPs were analyzed.

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