Drug-induced acute febrile neutrophilic dermatosis (Sweet syndrome): A case report presented at Delhi State Cancer Institute.

Sweet syndrome is a rare, etiologically unknown dermatosis that can be idiopathic or associated with certain clinical conditions. Among these conditions are infections, autoimmune diseases, inflammatory bowel diseases, vaccinations, the use of medications, and neoplasias. Hematological neoplasias, particularly acute myeloid leukemia, are the most commonly described; however, the condition may also be related to solid tumors, being those of the genitourinary tract the most associated with the syndrome.

Efficacy of avalglucosidase alfa on forced vital capacity percent predicted in treatment-naïve patients with late-onset Pompe disease: A pooled analysis of clinical trials.

Background: The efficacy of avalglucosidase alfa (AVA) versus alglucosidase alfa (ALG) on forced vital capacity percent predicted (FVCpp) in patients with late-onset Pompe disease (LOPD) has been assessed in the Phase 3 COMET trial (NCT02782741). Due to the rarity of LOPD and thus small sample size in COMET, additional data were analyzed to gain further insights into the efficacy of AVA versus ALG.

Methods: Data from treatment-naive patients with LOPD were pooled from COMET and Phase 1/2 NEO1/NEO-EXT (NCT01898364/NCT02032524) trials for patients treated with AVA, and Phase 3 LOTS trial (NCT00158600) for patients treated with ALG.

Applying the win ratio method in clinical trials of orphan drugs: an analysis of data from the COMET trial of avalglucosidase alfa in patients with late-onset Pompe disease.

Background: Clinical trials for rare diseases often include multiple endpoints that capture the effects of treatment on different disease domains. In many rare diseases, the primary endpoint is not standardized across trials. The win ratio approach was designed to analyze multiple endpoints of interest in clinical trials and has mostly been applied in cardiovascular trials.

Phytoremediation potential of Solanum viarum Dunal and functional aspects of their capitate glandular trichomes in lead, cadmium, and zinc detoxification.

In the present scenario, remediation of heavy metals (HMs) contaminated soil has become an important work to be done for the well-being of human and their environment. Phytoremediation can be regarded as an excellent method in environmental technologies. The present contemporary research explores the Solanum viarum Dunal function as a potential accumulator of hazardous HMs viz.

A universal dimensionless length scale in medium range order amorphous structures.

Our theoretical analysis reveals the existence of a previously unknown universality, namely, a dimensionless length scale, related to a ratio of medium and short range order structures of amorphous systems that originates from a conspiracy between dispersion forces among molecules and their phonon mediated coupling. The scale in turn gives rise to the structure lying underneath the low temperature universalities of many other properties e.g.

Universality of ultrasonic attenuation coefficient of amorphous systems at low temperatures.

The competition between unretarded dispersion interactions between molecules prevailing at medium range order length scales and their phonon induced coupling at larger scales leads to appearance of nano-scale sub structures in amorphous systems. The complexity of intermolecular interactions gives rise to randomization of their operators. Based on a random matrix modelling of the Hamiltonian and its linear response to an external strain field, we show that the ultrasonic attenuation coefficient can be expressed as a ratio of two crucial length-scales related to molecular dynamics.

Average density of states of amorphous Hamiltonians: role of phonon mediated coupling of nano-clusters.

Based on a description of an amorphous solid as a collection of coupled nanosize molecular clusters referred as basic blocks, we analyse the statistical properties of its Hamiltonian. The information is then used to derive the ensemble averaged density of the vibrational states (non-phonon) which turns out to be a Gaussian in the bulk of the spectrum and an Airy function in the low frequency regime. A comparison with experimental data for six glasses confirms validity of our theoretical predictions.

Low temperature heat capacity of nanosize amorphous solids.

Contrary to previous studies based on bulk materials, we analyze the behavior of the vibrational density of states (VDOS) and specific heat of an amorphous solid of nano-scales (∼3 nm) at low temperature. With Hamiltonian formulation based on the intermolecular dispersion forces, our analysis indicates a universal semi-circle form of the average VDOS in the bulk of the spectrum along with a super-exponentially increasing behavior in its edge. The latter in turn leads to a specific heat with a superlinear temperature () dependence below< 1even at nano-scales, and, surprisingly agreeing with the experiments although the latter are carried out at macroscopic scales.

Spectral statistics of multiparametric Gaussian ensembles with chiral symmetry.

The statistics of chiral matrix ensembles with uncorrelated but multivariate Gaussian distributed elements is intuitively expected to be driven by many parameters. Contrary to intuition, however, our theoretical analysis reveals the existence of a single parameter, a function of all ensemble parameters, which governs the dynamics of spectral statistics. The analysis not only extends the formulation (known as complexity parameter formulation) for Hermitian ensembles without chirality to those with it but also reveals the underlying connection between chiral complex systems with seemingly different system conditions as well as between other complex systems, e.

Stabilizing Terminal Ni(III)-Hydroxide Complex Using NNN-Pincer Ligands: Synthesis and Characterization.

The reaction of [Ni(COD)] (COD; cyclooctadiene) in THF with the NNN-pincer ligand bis(imino)pyridyl (L) reveals a susceptibility to oxidation in an inert atmosphere ([O] level <0.5 ppm), resulting in a transient Ni:dioxygen adduct. This reactive intermediate abstracts a hydrogen atom from THF and stabilizes an uncommon Ni(III) complex.

Statistical analysis of chiral structured ensembles: Role of matrix constraints.

We analyze the statistical properties of complex systems with specific conservation laws and symmetry conditions which lead to various constraints and thereby structures in their matrix representation. An increase of constraints leads to a variation of the spectral statistics from Wigner-Dyson to Poisson limits, but the eigenfunction statistics remains weakly multifractal in the bulk. For some constraints, the statistics not only lies between the two limits but is size-independent too, thus indicating a critical point.

Physical state of the culture medium triggers shift in morphogenetic pattern from shoot bud formation to somatic embryo in .

is a rich source of steroidal alkaloids that are important secondary metabolites with enormous pharmaceutical uses. Development of plantlets from somatic tissues, under in vitro conditions, takes place both through adventitious shoot bud differentiation or somatic embryogenesis (SE) pathway. We observed that the physical state of medium, solid or liquid, determined the regenerant differentiation patterns from root segment explants in .

Substituted versus Naked Thiourea Ligand Containing Pseudotetrahedral Cobalt(II) Complexes: A Comparative Study on Its Magnetization Relaxation Dynamics Phenomenon.

A series of mononuclear tetrahedral cobalt(II) complexes with the general molecular formula [Co(L)X] [where L = tetramethylthiourea ([(CH)N]C═S) and X = Cl (1), Br (2), and I (3)] were isolated, and their structures were characterized by single-crystal X-ray diffraction. The experimental direct-current magnetic data are excellently reproduced by fitting both χ T( T) and M( H) simultaneously using the spin Hamiltonian (SH) parameters D = -18.1 cm and g = 2.

Criticality in Brownian ensembles.

A Brownian ensemble appears as a nonequilibrium state of transition from one universality class of random matrix ensembles to another one. The parameter governing the transition is, in general, size-dependent, resulting in a rapid approach of the statistics, in infinite size limit, to one of the two universality classes. Our detailed analysis, however, reveals the appearance of a new scale-invariant spectral statistics, nonstationary along the spectrum, associated with multifractal eigenstates, and different from the two end-points if the transition parameter becomes size-independent.

Extended states with Poisson spectral statistics.

Contrary to the prevailing notion, we find that the spectrum associated with the extended states in a complex system may belong to the Poisson universality class if the system is subjected to a specific set of constraints. Our results are based on an exact theoretical as well as numerical analysis of column constrained chiral ensembles with circulant off-diagonal blocks and are relevant for a complete understanding of the eigenfunction localization and related physical properties.

Chronic Myeloid Leukemia with a Complex Variant 'Ph' Translocation That Develops in Breast Carcinoma, Postchemotherapy: A Rare but Treatable Entity.

We report a case of chronic myeloid leukemia (CML) that developed after postoperative chemotherapy with cyclophosphamide, doxorubicin and 5-fluorouracil (CAF) for breast cancer. A 55-year-old woman was diagnosed with invasive ductal carcinoma which was treated with a modified radical mastectomy followed by six cycles of CAF chemotherapy. Nine years later, she developed CML and locoregional recurrence.

Role of Halide Ions in the Nature of the Magnetic Anisotropy in Tetrahedral Co Complexes.

A series of mononuclear tetrahedral Co complexes with a general molecular formula [CoL X ] [L=thiourea and X=Cl (1), Br (2) and I (3)] were synthesized and their structures were characterized by single-crystal X-ray diffraction. Direct-current (dc) magnetic susceptibility [χ T(T) and M(H)] and its slow relaxation of magnetization were measured for all three complexes. The experimental dc magnetic data are excellently reproduced by fitting both χ T(T) and M(H) simultaneously with the parameters D=+10.

Cardiovascular sequel of neck irradiation in head and neck cancer patients.

Purpose: The baroreflex is an important afferent mechanism controlling autonomic functions. As afferent nerves course through the neck, they are susceptible to damage by neck irradiation in head and neck cancer patients. With increased survival of head and neck cancer patients because of improved therapy, the cardiovascular morbidity and mortality in them have become apparent and this is of clinical concern.

Quantification of coronary artery motion and internal risk volume from ECG gated radiotherapy planning scans.

Background: Radiotherapy for carcinoma of breast and thoracic structures involves inadvertent radiation to heart and coronary arteries (CA). Coronary artery stenosis in high radiation dose segments has been documented. Cardiac and respiratory motion induced displacement of CA and internal risk volume (IRV) margin remains inadequately quantified.

Universality classes in Coulomb blockade conductance peak-height statistics.

We investigate, using exact diagonalization techniques, the distribution of conductance peak heights in Coulomb blockade regime of a quantum dot connected to two leads under generic dot conditions. The study reveals a three-parametric dependence of the distribution: (i) two dot-lead contact characteristics and (ii) the complexity parameter, mimicking the combined effect of all dot conditions. This also indicates the presence of an infinite range of universality classes of conductance statistics, dominantly characterized just by the complexity parameter and global symmetry constraints.