Publications by authors named "Shuki Imaeda"
Article Synopsis
- - Mucopolysaccharidosis type IIIB is a serious neurological disorder caused by insufficient levels of the enzyme NAGLU, leading to harmful buildup of heparan sulfate in the body.
- - The study investigated a pharmacological chaperone strategy aimed at improving the activity of NAGLU in cells from affected patients, utilizing structures of existing inhibitors to develop new compounds.
- - Among the 17 new iminosugar C-glycosides created, one non-functionalized β-homoiminosugar unexpectedly emerged as the most effective, enhancing mutant NAGLU activity by 2.4 times at optimal concentration.
Capitalizing on a recently reported iminosugar-based aza-crown (ISAC) accessed by a double Staudinger azaWittig coupling reaction, we have expanded the structural diversity of this new family of sweet cyclam analogs. Replacement of the two secondary amines linking the iminosugar units by two amide bonds obtained a cyclodimerization by with BOP and DIPEA led to a macrocycle that did not demonstrate efficient Zn chelation unlike the parent ISAC. Introduction of two pyrene moieties on the secondary amines of the parent ISAC yielded a new fluoroionophore that selectively binds Hg in methanol.
View Article and Find Full Text PDFThe red maple and sugar maple (Acer rubrum and A. saccharum, respectively) contain acertannins (ginnalins and maplexins), galloylated derivatives of 1,5-anhydro-d-glucitol (1,5-AG, 1). These compounds have a variety of potential medicinal properties and we have shown that some of them promote the expression of ceramide synthase 3.
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