Publications by authors named "Shukai Wu"
Article Synopsis
- Moving computation units closer to sensors helps improve computing speed, power use, and data storage, with optical neural networks (ONNs) offering significant processing capabilities but facing limitations due to nonlinear activation and laser input dependence.
- A new design called multilayer optical neural network (MONN) introduces two convolution layers and a nonlinear layer for pre-sensor computations, utilizing passive masks and a quantum dot film to enhance performance.
- MONN is much smaller than current lens-based ONNs, achieving remarkable efficiency by off-loading up to 95% of complex computations to optical processes, paving the way for practical and power-efficient mobile vision solutions.
Background: Repetitive mild traumatic brain injury (rmTBI) often occurs in individuals engaged in contact sports, particularly boxing. This study aimed to elucidate the effects of rmTBI on phase-locking value (PLV)-based graph theory and functional network architecture in individuals with boxing-related injuries in five frequency bands by employing resting-state electroencephalography (EEG).
Methods: Twenty-fore professional boxers and 25 matched healthy controls were recruited to perform a resting-state task, and their noninvasive scalp EEG data were collected simultaneously.
Article Synopsis
- The study investigates cognitive impairment in patients with pituitary adenomas (PAs), specifically focusing on those with hyperprolactinemia (high prolactin levels).
- Results showed that patients had slower reaction times and altered brain activity patterns, indicating issues with attention and cognitive processing compared to healthy controls.
- The research suggests a link between cognitive deficits and high prolactin levels, highlighting the need for further studies on how these factors contribute to cognitive decline in pituitary adenoma patients.
Article Synopsis
- The study investigates the impact of repeated subconcussive head impacts on working memory and neural activity in boxing athletes compared to a control group.
- Results showed that boxers had lower accuracy, increased reaction times, and signs of working memory dysfunction, indicated by altered EEG patterns.
- The findings suggest that cumulative subconcussive impacts negatively affect cognitive performance, highlighting the need for better detection methods for memory-related issues in athletes.
Article Synopsis
- Recent studies have highlighted cognitive impairments from repetitive subconcussion, particularly affecting attention, though there's a lack of event-related potentials (ERPs) research in this area.
- In a study involving 27 paratroopers with subconcussion and 25 healthy controls, results from the Attention Network Test (ANT) showed that the subconcussion group had notably slower reaction times and difficulties with alertness.
- ERP findings indicated a reduced ability to efficiently use cues in the alerting network and deficits in attentional resource allocation in the executive control network of the subconcussion group, signaling potential cognitive damage.*
Background: Enhancing autophagy after traumatic brain injury (TBI) may decrease the expression of neuronal apoptosis-related molecules. Autophagy-mediated neuronal survival is regulated by the sirtuin family of proteins (SIRT). Omega-3 polyunsaturated fatty acids (ω-3 PUFA) are known to have antioxidative and anti-inflammatory effects.
View Article and Find Full Text PDFBackground: Microglial polarization and the subsequent neuroinflammatory response are contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile group box 1 (HMGB1) mediates the activation of the NF-κB pathway, and it is considered to be pivotal in the late neuroinflammatory response. Activation of the HMGB1/NF-κB pathway is closely related to HMGB1 acetylation, which is regulated by the sirtuin (SIRT) family of proteins.
View Article and Find Full Text PDFKLF16 suppresses human glioma cell proliferation and tumourigenicity by targeting TFAM.
Artif Cells Nanomed Biotechnol
August 2019
Background: This study aims to via unveiling the novel mechanisms of KLF16 in regulating expression of genes involved in glioma.
Methods: KLF16 or KLF16-siRNA was transfected to U87MG cells by lentivirus. Colony formation assay was applied for detecting cell proliferation.
Background: Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transmembrane receptor for advanced glycation end products (RAGE) and toll-like receptors (TLRs) to activate downstream signaling pathways, such as the nuclear factor (NF)-κB signaling pathway, leading to a cascade amplification of inflammatory responses, which are related to neuronal damage after TBI. Omega-3 polyunsaturated fatty acid (ω-3 PUFA) is a commonly used clinical immunonutrient, which has antioxidative and anti-inflammatory effects.
View Article and Find Full Text PDFIn this study, we investigated and modeled the performance of target pointing hand movements in a hand free, touchless 3D environment. The targets had different positions, sizes and distances. Performance measurements included total movement time and movement trajectories.
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