Publications by authors named "Shujun Shi"

Article Synopsis
  • - Zhenzhu Tongluo pills (ZZTL) have shown potential neuroprotective effects for treating neurobrucellosis (NB) in Inner Mongolia, but the specific mechanisms are not well understood.
  • - Through LC-MS analysis of cerebrospinal fluid (CSF) samples, 225 common metabolites were identified between NB patients and control subjects, with notable changes indicating dysregulation in purine metabolism and vitamin B deficiencies in NB patients that were reversed by ZZTL therapy.
  • - This study suggests that analyzing CSF metabolomics can help distinguish NB patients from healthy controls, offering useful insights for diagnosis and treatment strategies.
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Key Clinical Message: Heavy-chain deposition disease (HCDD), a rare monoclonal immunoglobulin deposition disease, involves truncated heavy-chain deposition in kidneys. Limited long-term data exist. We report a case of renal and cardiac failure with favorable outcomes post bortezomib-based therapy.

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This review focuses on , a Gram-negative bacterium that causes various infections and whose multidrug resistance has become a significant challenge in clinical practices. There are multiple bacterial mechanisms in that participate in bacterial colonization and immune responses. It is believed that outer membrane vesicles (OMVs) budding from the bacteria play a significant role in mediating bacterial survival and the subsequent attack against the host.

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Article Synopsis
  • - The study aimed to compare the effectiveness of two ultrasound-guided techniques—LAX-IP combined with SAX-OOP and modified dynamic needle tip positioning (MDNTP)—for radial artery catheterization in infants undergoing surgery.
  • - Conducted at Children's Hospital of Chongqing Medical University, 72 infants aged 1-12 months were randomly assigned to either the LAX-IP/SAX-OOP group or the MDNTP group for the procedure.
  • - Results showed that the LAX-IP/SAX-OOP technique had a significantly higher first-time success rate (75%) and shorter cannulation time (91.39 seconds) compared to MDNTP (36.1% success rate, 181 seconds), along with fewer
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Neurobrucellosis is the most morbid form in brucellosis disease. Metabolomics is an emerging method which intends to explore the global alterations of various metabolites in samples. We aimed to identify metabolites in cerebrospinal fluid (CSF) as biomarkers that were potentially unique for neurobrucellosis.

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Pregnancy toxemia (PT) is the most frequent metabolic disease of sheep during late pregnancy, which can lead to enormous economic losses in sheep farm industry. However, the underlying mechanism of PT in sheep has not been fully elucidated. High levels of β-hydroxy butyric acid (BHBA) exist in PT sheep.

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Background: Methods to determine the optimal insertion depth of ultrasound-guided supraclavicular approach to the subclavian vein (SCV) catheterization, alternatively used for central venous access, are debatable in children.

Aim: We investigated the applicability and reliability of the modified formula for determining the depth of SCV catheterization using an ultrasound-guided supraclavicular approach in children.

Methods: This prospective observational study included 36 children (age <6 years; weight ≥5 kg) scheduled to undergo congenital heart disease surgery.

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Objective: The purpose of this study was to demonstrate the prognostic role of inflammatory biomarkers in patients with laryngeal squamous cell carcinoma.

Methods: For this study, we enrolled 151 patients who had undergone surgery for laryngeal squamous cell carcinoma. We assessed the preoperative neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), mean platelet volume, red cell distribution width, and alkaline phosphatase.

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Some primary and secondary liver carcinomas cannot be resected using a conventional approach due to their size, location, or major vascular invasion. The aim of this study was to explore the application of ex vivo liver resection and autotransplantation for complicated HB in children. A 1.

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To summarize the clinical characteristics, diagnosis, treatment and prognosis among 152 children with annular pancreas (AP). A retrospective review of 152 patients with AP who were treated with surgical repair between January 2009 and August 2017 was performed at our pediatric surgical units. Presenting symptoms, birth weight, radiological findings, associated anomalies, the type of surgery performed were analyzed.

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Background: This study aimed to analyze the risk factors and treatment efficacy of neurobrucellosis.

Material/methods: A cross-sectional epidemiologic survey was carried out in 557 patients with brucellosis by specially trained neurologic clinicians. Sixty-six patients with neurobrucellosis were treated with doxycycline, rifampicin, and ceftriaxone sodium as standard medication and evaluated for efficacy on a regular basis.

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Recent work has shown that mouse and human fibroblasts can be reprogrammed to cardiomyocyte-like cells with a combination of transcription factors. Current research has focused on improving the efficiency and mechanisms for fibroblast reprogramming. Previously, it has been reported that hypoxia enhances fibroblast cell reprogramming to pluripotent stem cells.

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Article Synopsis
  • The study aimed to investigate the effects of Shexiang Baoxin pill (SBP) on vascular endothelial function in patients with type 2 diabetes and angina pectoris.
  • After randomly assigning 111 patients to either the SBP group or a control group treated with isosorbide mononitrate, they were monitored for angina episodes and vascular changes over 6 months.
  • Results showed no significant differences in angina episodes or medication use between the groups, but the SBP group exhibited a notable improvement in endothelium-dependent vascular relaxation after treatment, indicating enhanced endothelial function.
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