Influence of Supercritical Conditions on Isothermal Adsorption Capacity Calculation of Methane and Model Optimization.

The study of isothermal adsorption models for coal and methane under supercritical conditions helps us to understand the gas content distribution in coal seams and improve gas management in coal mines. Coal samples from the Hebi mine and Longshan coal mine were selected for this research. Using the weight method, isothermal adsorption curves of supercritical methane at temperatures of 308, 313, and 318 K were measured.

Determination on Effective Drainage Radius of In-Seam Borehole Based on Gas Content Test and Numerical Simulation Calculation Method.

In order to accurately and efficiently determine the effective drainage radius of the in-seam borehole, the advantages and disadvantages of the current effective drainage radius test methods are analyzed, and the method of combining the gas content field and numerical simulation calculation is proposed to accurately determine the effective drainage radius of the borehole, which is applied in the mine. The results show that the method combining gas content test and numerical simulation calculation has the advantages of a short measurement period and advanced means. The effective drainage radius of the borehole increases rapidly at the initial stage of gas drainage and then gradually slows, eventually reaching a limit value.

Generation of cutting heat and simulation of core tube wall temperature during coring in primary structure coal seam.

When the drilling core method is used to determine the coalbed gas content, the cutting heat generated by the core bit cutting coal will increase the core tube temperature, and the excessively high core tube temperature will have an heating effect on the coal core, which will accelerate the coal core gas desorption rate and increase the gas loss amount. The generation of cutting heat of core bit and the measurement of core tube temperature are the basis for grasping the gas desorption law of coal core and projecting the amount of gas loss. Firstly, the self-developed core tube temperature measurement device was used to conduct on-site core temperature measurement experiments at different cutting speeds.

SH-Alb inhibits phenotype remodeling of pro-fibrotic macrophage to attenuate liver fibrosis through SIRT3-SOD2 axis.

Albumin has a variety of biological functions, such as immunomodulatory and antioxidant activity, which depends largely on its thiol activity. However, in clinical trials, the treatment of albumin by injection of commercial human serum albumin (HSA) did not achieve the desired results. Here, we constructed reduced modified albumin (SH-Alb) for in vivo and in vitro experiments to investigate the reasons why HSA did not achieve the expected effects.

Frequency tuning and automatic frequency tracking of shunted piezoelectric transducers.

Piezoelectric ultrasonic transducers, vital in medical devices and aerospace, often face challenges like resonant frequency shifts and impedance variations affecting their operational efficiency. This paper introduces a shunted piezoelectric transducer which could tune itself by digitally programmable inductance. A transformer and inductance-capacitance matching network ensures enhanced compatibility and impedance management.

Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated macrophage activation by ERK pathway to accelerate liver injury.

Liver injury is closely associated with macrophage activation following HBV infection. Our previous study showed that only HBeAg, but not HBsAg and HBcAg, stably enhances inflammatory cytokine production in macrophages. And we also indicated that HBeAg could induce macrophage activation via TLR2 and thus aggravate the progression of liver fibrosis.

Albumin, an interesting and functionally diverse protein, varies from 'native' to 'effective' (Review).

Human serum albumins (HSAs) are synthesized in the liver and are the most abundant proteins in plasma of healthy human. They play an important role in the pathophysiological processes of the liver and even the whole organism. Previous studies have mainly focused on the regulation of HSAs' expression.

RNF144A promotes antiviral responses by modulating STING ubiquitination.

Stimulator of interferon (IFN) genes (STING, also named MITA, ERIS, MPYS, or TMEM173) plays an essential role in DNA virus- or cytosolic DNA-triggered innate immune responses. Here, we demonstrate that the RING-in-between RING (RBR) E3 ubiquitin ligase family member RING-finger protein (RNF) 144A interacts with STING and promotes its K6-linked ubiquitination at K236, thereby enhancing STING translocation from the ER to the Golgi and downstream signaling pathways. The K236R mutant of STING displays reduced activity in promoting innate immune signal transduction.

Race between virus and inflammasomes: inhibition or escape, intervention and therapy.

The inflammasome is a multiprotein complex that further regulates cell pyroptosis and inflammation by activating caspase-1. The assembly and activation of inflammasome are associated with a variety of diseases. Accumulative studies have shown that inflammasome is a key modulator of the host's defense response to viral infection.

Epithelial TIPE1 Protein Guards against Colitis by Inhibiting TNF-α-Mediated Inflammation.

Intestinal epithelial cells (IECs) at the internal/external interface orchestrate the mucosal immune response, and IEC dysfunction has been linked to multiple inflammatory diseases, including inflammatory bowel disease. In this study, we found that a member of the TNF-α-induced protein 8 (TNFAIP8 or TIPE) family called TIPE1 is indispensable for maintaining epithelial cell barrier integrity and homeostasis under inflammatory conditions. TIPE1-deficient mice, or chimeric mice that were deficient in TIPE1 in their nonhematopoietic cells, were more sensitive to dextran sulfate sodium-induced experimental colitis; however, TIPE1 deficiency had no impact on the development of inflammation-associated and sporadic colorectal cancers.

Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.

Interferon-inducible protein 16 (IFI16) plays a critical role in antiviral innate immune responses against DNA viruses. Although the acetylation of IFI16 is crucial to its cytoplasmic translocation and downstream signal transduction, the regulation of IFI16 acetylation remains unclear. In this study, we demonstrated that the NAD-dependent deacetylase silent information regulatory 1 (Sirtuin1, Sirt1) interacted with IFI16 and decreased the acetylation of IFI16, resulting in the inhibition of IFI16 cytoplasmic localization and antiviral responses against DNA virus and viral DNA in human cells.

TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during infection.

is a widely used infection model for the research on pathogenesis and host defense against gram-positive intracellular bacteria. Emerging evidence indicates that posttranslational modifications play a critical role in the regulation of macroautophagy/autophagy. However, little is known about the posttranslational modifications of ATG7, the essential protein in the autophagy process.

Research on Factors and Influencing Correlation of Coal Core Temperature during Coring.

The core-tube method is a common method to measure the coal seam gas content (CSGC). However, cutting heat and friction heat will be generated in the core-tube coring process, which will increase the coal core temperature and the coal core gas loss, thus resulting in a large error in the determination of the gas content. The accuracy of the gas content determination is closely related to the temperature variation of coal core during core-taking.

Quantitative phase imaging in digital holographic microscopy based on image inpainting using a two-stage generative adversarial network.

Based on the hologram inpainting via a two-stage Generative Adversarial Network (GAN), we present a precise phase aberration compensation method in digital holographic microscopy (DHM). In the proposed methodology, the interference fringes of the sample area in the hologram are firstly removed by the background segmentation via edge detection and morphological image processing. The vacancy area is then inpainted with the fringes generated by a deep learning algorithm.

Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.

The antiviral innate immunity is the first line of host defense against viral infection. Mitochondrial antiviral signaling protein (MAVS, also named Cardif/IPS-1/VISA) is a critical protein in RNA virus-induced antiviral signaling pathways. Our previous research suggested that E3 ubiquitin-protein ligases RING-finger protein (RNF90) negatively regulate cellular antiviral responses by targeting STING for degradation, though its role in RNA virus infection remains unknown.

E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation.

Intestinal fungi are critical for modulating host immune homeostasis and underlying mechanisms remain unclear. We show that dendritic cell (DC)-specific deficiency of casitas B-lineage lymphoma (c-Cbl) renders mice susceptible to dextran sodium sulfate (DSS)-induced colitis. Mechanistically, we identify that c-Cbl functions downstream of Dectin-2 and Dectin-3 to mediate the ubiquitination and degradation of noncanonical nuclear factor κB subunit RelB.

Identification of the first Alu-mediated gross deletion involving the BCKDHA gene in a compound heterozygous patient with maple syrup urine disease.

Aims: To investigate a family with clinical symptoms of maple syrup urine disease and reveal a genetic cause underlying this disease.

Methods: Targeted capture sequencing was used to screen for mutations in the patient. Real-Time PCR was carried out to perform exon 1, 5, 9 CNV analysis of samples from the patient's father, mother and sister.

RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.

Mediator of IRF3 activation (MITA, also named as STING/ERIS/MPYS/TMEM173), is essential to DNA virus- or cytosolic DNA-triggered innate immune responses. In this study, we demonstrated the negative regulatory role of RING-finger protein (RNF) 90 in innate immune responses targeting MITA. RNF90 promoted K48-linked ubiquitination of MITA and its proteasome-dependent degradation.

Expanded newborn screening for inborn errors of metabolism by tandem mass spectrometry in newborns from Xinxiang city in China.

Background: Tandem mass spectrometry is a powerful technology available in China over the last 15 years. The development of tandem mass spectrometry had made it possible to rapidly screen newborns for inborn errors of metabolism. The aim of this study was to determine the birth incidence of inborn errors of metabolism through expanded screening of newborns by tandem mass spectrometry in Xinxiang area.

Physical Simulation of Temperature and Pressure Evolvement in Coal by Different Refrigeration Modes for Freezing Coring.

Reduction of gas desorption capacity by cooling coal samples seems a feasible way to improve the accuracy of gas in place estimation. To find an efficient refrigeration mode for the freezing coring technology, the freezing tests for coal containing gas (at 0, 1.09, and 2.

Robust Stereo Visual-Inertial Odometry Using Nonlinear Optimization.

The fusion of visual and inertial odometry has matured greatly due to the complementarity of the two sensors. However, the use of high-quality sensors and powerful processors in some applications is difficult due to size and cost limitations, and there are also many challenges in terms of robustness of the algorithm and computational efficiency. In this work, we present VIO-Stereo, a stereo visual-inertial odometry (VIO), which jointly combines the measurements of the stereo cameras and an inexpensive inertial measurement unit (IMU).

Down-regulation of mitogen-activated protein kinases and nuclear factor-κB signaling is involved in rapamycin suppression of TLR2-induced inflammatory response in monocytic THP-1 cells.

Tripalmitoyl-S-glycero-Cys-(Lys) 4 (Pam3CSK4) interacted with TLR2 induces inflammatory responses through the mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) signal pathway. Rapamycin can suppress TLR-induced inflammatory responses; however, the detailed molecular mechanism is not fully understood. Here, the mechanism by which rapamycin suppresses TLR2-induced inflammatory responses was investigated.

Real-time EEG-based detection of fatigue driving danger for accident prediction.

This paper proposes a real-time electroencephalogram (EEG)-based detection method of the potential danger during fatigue driving. To determine driver fatigue in real time, wavelet entropy with a sliding window and pulse coupled neural network (PCNN) were used to process the EEG signals in the visual area (the main information input route). To detect the fatigue danger, the neural mechanism of driver fatigue was analyzed.

Vapor-phase synthesis, growth mechanism and thickness-independent elastic modulus of single-crystal tungsten nanobelts.

Single-crystal tungsten nanobelts with thicknesses from tens to hundreds of nanometers, widths of several micrometers and lengths of tens of micrometers were synthesized using chemical vapor deposition. Surface energy minimization was believed to have played a crucial role in the growth of the synthesized nanobelts enclosed by the low-energy {110} crystal planes of body-centered-cubic structure. The anisotropic growth of the crystallographically equivalent {110} crystal planes could be attributable to the asymmetric concentration distribution of the tungsten atom vapor around the nanobelts during the growth process.