[Formula: see text]-Improved nonparallel support vector machine.

In this paper, a [Formula: see text]-improved nonparallel support vector machine ([Formula: see text]-IMNPSVM) is proposed to solve binary classification problems. In this model, we use related ideas of [Formula: see text]-support vector machine([Formula: see text]-SVM), the parameter [Formula: see text] is introduced to control the limits of the support vectors percentage. In the objective function, the parameter [Formula: see text] is increased to ensure that [Formula: see text]-band is kept as small as possible.

Smoothing approximation to the lower order exact penalty function for inequality constrained optimization.

For inequality constrained optimization problem, we first propose a new smoothing method to the lower order exact penalty function, and then show that an approximate global solution of the original problem can be obtained by solving a global solution of a smooth lower order exact penalty problem. We propose an algorithm based on the smoothed lower order exact penalty function. The global convergence of the algorithm is proved under some mild conditions.

A novel heterozygous NR1H4 termination codon mutation in idiopathic infantile cholestasis.

Background: This study aimed to evaluate the genetic effect of the NR1H4 gene in the pathogenesis of idiopathic infantile cholestasis of Chinese subjects in Guangxi, China.

Methods: Seventy-eight patients with idiopathic infantile cholestasis served as a study group and 95 infants without cholestasis as controls. Genomic DNA was extracted from peripheral venous blood leucocytes by phenol chloroform procedures.

[Effect of oral glutamine on intestinal barrier function in young rats with endotoxemia].

Objective: To study the effect of glutamine on intestinal barrier function by examining the changes of plasma D-lactic levels and diamine oxidase (DAO) levels in plasma and intestinal tissue after glutamine intervention in young rats with endotoxemia.

Methods: Eighty 18-day-old rats were randomly divided into endotoxemia and glutamine intervention groups (n=40 each). Endotoxemia was induced by lipopolysaccharide (LPS) injection.

[NF-κB levels in the liver of young rats with endotoxemic liver injury].

Objective: To study hepatic NF-κB level following endotoxemic liver injury, and its relationship with hepatic TNF-α and IL-6 levels in young rats.

Methods: Forty 18-day-old rats were randomly assigned to a normal control and an endotoxemia group. Endotoxemia was induced by lipopolysaccharide injection (LPS, 5 mg/kg).

[Relationship between gene polymorphisms in MMP-9 and Helicobacter pylori-related upper gastrointestinal disease in children].

Objective: To investigate the relationship of the promoter of matrix metalloproteinase-9 (MMP-9) gene polymorphisms with the susceptibility and clinical features of Helicobacter pylori (H. pylori)-related chronic gastritis and duodenal ulcer in children.

Methods: One hundred children with chronic gastritis, 32 children with duodenal ulcer and 102 healthy children were enrolled.

Multidrug resistance protein 3 R652G may reduce susceptibility to idiopathic infant cholestasis.

Aim: To evaluate the role of genetic factors in the pathogenesis of idiopathic infant cholestasis.

Methods: We performed a case-control study, including 78 infants with idiopathic infant cholestasis and 113 healthy infants as controls. Genomic DNA was extracted from peripheral venous blood leukocytes using phenol chloroform methodology.