Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods.

Ti-24Nb-4Zr-8Sn (Ti2448) alloy is a novel low elastic modulus β-titanium alloy without toxic elements. It also has the advantage of high strength, so it has potential application prospects for implantation. To develop its osteogenic effects, it can be modified by electrochemical, and physical processes.

A composite carbon-based solid acid-supported palladium catalyst (Pd/C-SOH) for hydrogenolysis of plant-derived polymeric proanthocyanidins.

A composite catalyst, Pd/C-SOH, has been prepared to depolymerize plant-derived polymeric proanthocyanidins (PPC). Different reaction conditions were explored and the catalyst was shown to have good performance and recyclability, as well as good thermal and acid-base stability. UV, FTIR and H NMR analyses showed that the depolymerization products (oligomeric proanthocyanidins, OPC) retained a condensed flavanol polyphenol structure and that the basic structural units of the polymers had not been destroyed.

Biofunctional magnesium coated Ti6Al4V scaffold enhances osteogenesis and angiogenesis and for orthopedic application.

The insufficient osteogenesis and osseointegration of porous titanium based scaffold limit its further application. Early angiogenesis is important for scaffold survival. It is necessary to develop a multifunctional surface on titanium scaffold with both osteogenic and angiogenic properties.

Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration.

Bioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microstructurally. The studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared , the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications.

Exogenous diethyl aminoethyl hexanoate ameliorates low temperature stress by improving nitrogen metabolism in maize seedlings.

Spring maize sowing occurs during a period of low temperature (LT) in Northeast China, and the LT suppresses nitrogen (N) metabolism and photosynthesis, further reducing dry matter accumulation. Diethyl aminoethyl hexanoate (DA-6) improves N metabolism; hence, we studied the effects of DA-6 on maize seedlings under LT conditions. The shoot and root fresh weight and dry weight decreased by 17.

Biomineralized nanosilica-based organelles endow living yeast cells with non-inherent biological functions.

We propose a biomimetic strategy to construct engineered yeast cells (EYCs) by building intracellular silica nanoscaffolds as biomimetic organelles. These nanosilica-based organelles can coordinate with loaded drug and yeast as a shell could prevent drug leakage. In vivo results show that EYCs serve as a dually responsive drug delivery system, targeted with extracellular caps (folate) and triggered by intracellular SiO2 at the low pH of cancer tissue.

Fabrication of dually N/S-doped carbon from biomass lignin: Porous architecture and high-rate performance as supercapacitor.

The lignin amine (LA) was exploited to prepare dually N/S-doped carbon (NSC), which was endowed with intriguing porous structure by FeO template. N and S elements, originating from LA, are doped into the materials. NSC possesses diverse-scale 3D pores.

Organoboron-Functionalization Enables the Hierarchical Assembly of Giant Polyoxometalate Nanocapsules.

The aggregation of molecular metal oxides into larger superstructures can bridge the gap between molecular compounds and solid-state materials. Here, we report that functionalization of polyoxotungstates with organo-boron substituents leads to giant polyoxometalate-based nanocapsules with dimensions of up to 4 nm. A "lock and key" mechanism enables the site-specific anchoring of aromatic organo-boronic acids to metal-functionalized Dawson anions [M P W O ] (M=Ta or Nb ), resulting in unique nanocapsules containing up to twelve POM units.

Synthesis, crystal structures and, magnetic and photoluminescence properties of lanthanide-based metal-organic frameworks constructed with 2,5-dihydroxybenzene-1,4-dicarboxylic acid.

Four new lanthanide(iii) coordination polymers (1-4) have been synthesized by using 2,5-dihydroxybenzene-1,4-dicarboxylate (Dhbdc, CHO ) as a ligand and characterized by elemental analysis, infrared spectroscopy, TGA-DSC (Thermogravimetric Analysis-Differential Scanning Calorimetry) and single crystal X-ray diffraction studies. The isolated complexes include; [Ce(Dhbdc)(HO)Cl] (1) and [Ln(Dhbdc)(HO)] ·3(CHO)·HO [Ln = Eu (2), Gd (3) and Tb (4)]. The structural analysis reveals that compound 1 is a two-dimensional polymer in which the cerium atoms are coordinated by six oxygen and two bridging chloride ions adopting a dodecahedral geometry.

Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs.

The molecular mechanisms governing the secretion of the non-coding genome are poorly understood. We show herein that cyclin D1, the regulatory subunit of the cyclin-dependent kinase that drives cell-cycle progression, governs the secretion and relative proportion of secreted non-coding RNA subtypes (miRNA, rRNA, tRNA, CDBox, scRNA, HAcaBox. scaRNA, piRNA) in human breast cancer.

Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits.

Background: This study was to evaluate the effects of low-intensity collimated pulse ultrasound (LICU) and low-intensity focused-pulse ultrasound (LIFU) stimulation on the osteogenesis in the porous silicon carbide (SiC) scaffold implanted in the rabbit mandible.

Methods: Rabbits were randomly divided into LIFU group, LICU group and control group (without ultrasound treatment). The intensities of LICU and LIFU were 30 and 300 mW/cm, respectively.

Simultaneous removal of Pb, Cu and Cd ions from wastewater using hierarchical porous polyacrylic acid grafted with lignin.

In PAA-g-lignin, phase separation, caused by the difference in expansion properties between lignin and polyacrylic acid, is used to build a porous hydrogel. In this study, PAA-g-APL was produced by grafting polyacrylic acid with acid-pretreated alkali lignin. Acid-pretreated alkali lignin acts as a hierarchical pore-forming agent that enhances the simultaneous adsorption capacities for Pb, Cu and Cd ions from wastewater.

In-situ monitoring of the electrochemical behavior of cellular structured biomedical Ti-6Al-4V alloy fabricated by electron beam melting in simulated physiological fluid.

Ti-6Al-4V alloys with cellular structure fabricated by additive manufacturing are currently of significant interest because their modulus is comparable to bone and the cellular structure allows the cells to penetrate and exchange nutrients, promoting osseointegration. We describe here a unique simulation device that replaces the traditional steady electrochemistry approach, enabling in-situ study of variation of ion concentration and surface potential with pore depth for cellular structured Ti-6Al-4V alloys fabricated by electron beam melting (EBM) in phosphate buffered saline (PBS). This approach addresses the scientific gap on the electrochemical behavior of cellular structured titanium alloys.

Targeted Inhibition of miR-221/222 Promotes Cell Sensitivity to Cisplatin in Triple-Negative Breast Cancer MDA-MB-231 Cells.

Cisplatin has been widely used in the treatment of a various types of cancers including triple-negative breast cancer (TNBC) by damaging DNA and inducing apoptosis. However, its anti-cancer effects are often limited due to chemo-resistance, which is one of the main reasons causing cancer relapse and metastasis. To overcome resistance, cisplatin is often used in combination with other drugs or molecules.

Near-Infrared-Detached Adhesion Enabled by Upconverting Nanoparticles.

Achieving efficient and biocompatible detachment between adhered wet materials (i.e., tissues and hydrogels) is a major challenge.

MiR-301a promotes embryonic stem cell differentiation to cardiomyocytes.

Background: Cardiovascular disease is the leading cause of death worldwide. Tissue repair after pathological injury in the heart remains a major challenge due to the limited regenerative ability of cardiomyocytes in adults. Stem cell-derived cardiomyocytes provide a promising source for the cell transplantation-based treatment of injured hearts.

Numerical and experimental studies on a novel magneto-rheological fluid brake based on fluid-solid coupling.

The previous work of the authors indicated that the fluid-solid coupling effect of the magneto-rheological fluid and the brake disc is a necessary focus during braking process. In this study, a novel design of magneto-rheological fluid brake was proposed and studied theoretically and numerically, aiming to solve the prominent problem of heat dissipation, especially in the case of single emergency braking. First, based on the modified Bingham model, a parameter defined as the apparent equivalent viscosity was utilized to represent the relationship of magnetic field, flow field, and temperature field.

Synthesis, Crystal Structures and Photoluminescent Properties of One-Dimensional Europium(III)- and Terbium(III)-Glutarate Coordination Polymers, and Their Applications for the Sensing of Fe and Nitroaromatics.

Two lanthanide-glutarate coordination polymers, . : {[Eu(CHO)(HO)]Cl} , () and [Tb(CHO)(CHO)(HO)] , () have been synthesized and characterized by IR spectroscopy, thermogravimetric analysis, and X-ray crystallography. In , the Eu(III) ions are coordinated by four O atoms from two bidentate chelating carboxylate groups, one O atom from a bridging carboxylate group and four O atoms from water molecules adopting an EuO distorted tri-capped trigonal prismatic coordination geometry.

Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis.

Background: In recent years, long non-coding RNAs (lncRNAs) are of great importance in development of different types of tumors, while the function of lncRNA ZFAS1 is rarely discussed in esophageal squamous cell carcinoma (ESCC). Therefore, we performed this study to explore the expression of exosomal lncRNA ZFAS1 and its molecular mechanism on ESCC progression.

Methods: Expression of ZFAS1 and miR-124 in ESCC tissues was detected.

Palladium(ii) complexes supported by PBP and POCOP pincer ligands: a comparison of their structure, properties and catalytic activity.

A Pd(ii) chloride complex supported by a Yamashita-Nozaki PBP pincer ligand, [C6H4-1,2-(NCH2PtBu2)2B]PdCl (1a), was synthesized. The structure, properties and catalytic activity of complex 1a were compared with those of the corresponding POCOP pincer complex [C6H3-2,6-(OPtBu2)2]PdCl (2a). It was found that the Pd centre in complex 1a is more electron rich and easier to be oxidized than that in complex 2a; complex 1a is a much better catalyst for Suzuki-Miyaura cross-coupling reactions than complex 2a.

Lipoxin A4 attenuates hyperoxia‑induced lung epithelial cell injury via the upregulation of heme oxygenase‑1 and inhibition of proinflammatory cytokines.

The present study examined whether lipoxin A4 (LXA4) increases the expression of HO‑1, and inhibits the production of interleukin 6 (IL‑6) and monocyte chemotactic protein 1 (MCP‑1) in LXA4‑induced protection during hyperoxia‑induced injury in murine lung epithelial cells (MLE‑12) and what signal pathway may participate in the actions of LXA4 inhibiting IL‑6 and MCP‑1. MLE‑12 cells were exposed to air or hyperoxia with or without pretreatment with LXA4, Zinc protoporphyrin IX (ZnPP‑IX), IL‑6, anti‑IL‑6, MCP‑1, anti‑MCP‑1, inhibitors of p38 mitogen‑activated protein kinase (p38 MAPK), protein kinase B (Akt) and extracellular signal‑regulated kinase 1/2 (ERK1/2) signaling pathways. The cell survival rates, cell viability, apoptosis rates, expression of superoxide dismutase (SOD), heme oxygenase‑1 (HO‑1), IL‑6 and MCP‑1, and the activations of p38 MAPK, ERK1/2 and Akt were measured.

Carbon Dots as a Promising Green Photocatalyst for Free Radical and ATRP-Based Radical Photopolymerization with Blue LEDs.

Carbon dots (CDs) have been used for the first time as a sensitizer to initiate and activate free radical and controlled radical polymerization, respectively, based on an ATRP protocol with blue LEDs. Consideration of diverse heteroatom-doped CDs indicated that N-doped CDs could serve as an effective photocatalyst and photosensitizer in combination with LEDs emitting either at 405 nm or 470 nm. Free radical polymerization was initiated by combining the CDs with an iodonium or sulfonium salt in tri(propylene glycol) diacrylate.

Construction of heterostructured g-CN/ZnO/cellulose and its antibacterial activity: experimental and theoretical investigations.

A g-CN/ZnO/cellulose ternary composite (labeled as CNZCel) with an ordered structure and excellent antibacterial properties has been successfully synthesized via a facile method. Its morphology, microstructure and components have been analyzed by using XRD, SEM, TEM and EDS, and the results corroborate the co-existence of three components in the ternary composite. It is revealed that ZnO particles are connected to the layered g-CN and simultaneously attached to the cellulose substrate.

Altered expression of DLG1-AS1 distinguished papillary thyroid carcinoma from benign thyroid nodules.

Background: Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN patients and healthy controls.

Methods: In this study DLG1-AS1 and miR-199a-3p in plasma of both PTC patients and BTN patients were detected by qPCR.