Adverse Outcome Pathway-Based Strategies to Mitigate AgSe Quantum Dot-Induced Neurotoxicity.

Silver selenide quantum dots (AgSe QDs) show great advantages in tumor imaging due to their excellent optical performance and good biocompatibility. However, the ultrasmall particle size of AgSe QDs allows them to cross the blood-brain barrier, thus potentially affecting the central nervous system. Therefore, risk assessment and response strategies for AgSe QDs are important.

Exposure of quantum dots in the nervous system: Central nervous system risks and the blood-brain barrier interface.

Quantum dots currently possess significant importance in the field of biomedical science. Upon introduction into the body, quantum dots exhibit a tendency to accumulate in diverse tissues including the central nervous system (CNS). Consequently, it becomes imperative to devote specific attention to their potential toxic effects.

Oropharyngeal aspirated Ag/TiO nanohybrids: Transformation, distribution and toxicity.

The wide application of Ag-loaded TiO nanohybrids photocatalysts on environment and energy increases the lung exposure risk to humans. Ag/TiO nanohybrids inhalation can cause pulmonary toxicity, and there are concerns about whether the loaded silver can be released and cause toxic effects on extrapulmonary organs. Therefore, in this study, the possible biotransformation, biodistribution, and toxicity of oropharyngeal aspirated Ag/TiO nanohybrids were investigated first time in vitro and in vivo to answer this question.