METTL14 suppresses the expression of YAP1 and the stemness of triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) has pronounced stemness that is associated with relapse. N-methyladenosine (mA) plays a crucial role in shaping cellular behavior by modulating transcript expression. However, the role of mA in TNBC stemness, as well as the mechanisms governing its abundance, has yet to be elucidated.

B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials.

Unlabelled: Our study showed that B vitamins did not have significant effect on fracture incidence, bone mineral density, and bone turnover markers. However, the research data of B vitamins on bone mineral density and bone turnover markers are limited, and more clinical trials are needed to draw sufficient conclusions.

Purpose: The objective of this study was to identify the efficacy of B vitamin (VB) (folate, B6, and B12) supplements on fracture incidence, bone mineral density (BMD), and bone turnover markers (BTMs).

Ultrastable Organic Anode Enabled by Electrochemically Active MXene Binder toward Advanced Potassium Ion Storage.

Conjugated carbonyl compounds are regarded as promising organic anode materials for potassium ion batteries (PIBs) due to their rich redox sites, excellent reversibility, and structural tunability, but their low electrical conductivity and severe solubility in organic electrolytes have substantially restricted their practical application. Herein, 2D MXene is utilized as an electrochemically active binder to fabricate perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA) electrodes for high-performance PIBs. MXene, coupled with Super-P particles, served as a binder and conductive matrix to facilitate rapid ion and electron transport, restrain the solubility of PTCDA, promote potassium adsorption, and alleviate the volume expansion of PTCDA during potassiation.

Encapsulating Bi Nanoparticles in Reduced Graphene Oxide with Strong Interfacial Bonding toward Advanced Potassium Storage.

Bismuth (Bi) is regarded as a promising anode material for potassium ion batteries (PIBs) due to its high theoretical capacity, but the huge volume expansion during potassiation and intrinsic low conductivity cause poor cycle stability and rate capability. Herein, a unique Bi nanoparticles/reduced graphene oxide (rGO) composite is fabricated by anchoring the Bi nanoparticles over the rGO substrate through a ball-milling and thermal reduction process. As depicted by the in-depth XPS analysis, strong interfacial Bi-C bonding can be formed between Bi and rGO, which is beneficial for alleviating the huge volume expansion of Bi during potassiation, restraining the aggregation of Bi nanoparticles and promoting the interfacial charge transfer.

Materials Design and System Innovation for Direct and Indirect Seawater Electrolysis.

Green hydrogen production from renewably powered water electrolysis is considered as an ideal approach to decarbonizing the energy and industry sectors. Given the high-cost supply of ultra-high-purity water, as well as the mismatched distribution of water sources and renewable energies, combining seawater electrolysis with coastal solar/offshore wind power is attracting increasing interest for large-scale green hydrogen production. However, various impurities in seawater lead to corrosive and toxic halides, hydroxide precipitation, and physical blocking, which will significantly degrade catalysts, electrodes, and membranes, thus shortening the stable service life of electrolyzers.

CuZnSnS (CZTS) for Photoelectrochemical CO Reduction: Efficiency, Selectivity, and Stability.

Massive emissions of carbon dioxide (CO) have caused environmental issues like global warming, which needs to be addressed. Researchers have developed numerous methods to reduce CO emissions. Among these, photoelectrochemical (PEC) CO reduction is a promising method for mitigating CO emissions.

Cd-Free Pure Sulfide Kesterite Cu ZnSnS Solar Cell with Over 800 mV Open-Circuit Voltage Enabled by Phase Evolution Intervention.

The Cd-free Cu ZnSnS (CZTS) solar cell is an ideal candidate for producing low-cost clean energy through green materials owing to its inherent environmental friendliness and earth abundance. Nevertheless, sulfide CZTS has long suffered from severe open-circuit voltage (V ) deficits, limiting the full exploitation of performance potential and further progress. Here, an effective strategy is proposed to alleviate the nonradiative V loss by manipulating the phase evolution during the critical kesterite phase formation stage.

Composition-driven morphological evolution of BaTiO nanowires for efficient piezocatalytic hydrogen production.

Hydrogen production from water by piezocatalysis is very attractive owing to its high energy efficiency and novelty. BaTiO, a highly piezoelectric material, is particularly suitable for this application due to its high piezoelectric potential, non-toxic nature, and physicochemical stability. Owing to the critical role of morphology on properties, one-dimensional (1D) materials are expected to exhibit superior water-splitting performance and thus there is a need to optimise the processing conditions to develop outstanding piezocatalysts.

Real world practice of postoperative radiotherapy for patients with completely resected pIIIA-N2 non-small cell lung cancer: a national survey of radiation oncologists in China.

Background: Results from Lung ART and PORT-C trials suggest that postoperative radiotherapy (PORT) cannot routinely be recommended as standard treatment in completely resected pIIIA-N2 NSCLC patients, but their effects on the real-world practice of PORT in China remain unclear.

Methods: A national cross-section survey was conducted by using an online survey service. Participants were voluntarily recruited using a river sampling strategy.

Efficacy and safety of immune checkpoint inhibitors plus anlotinib in small cell lung cancer with brain metastases: a retrospective, multicentre study.

Background: Previous studies showed that both immune checkpoint inhibitors (ICIs) and anlotinib have central nervous system (CNS) efficacy. This study aimed to evaluate the efficacy and safety of ICIs combined with anlotinib in small cell lung cancer (SCLC) patients with brain metastases (BMs).

Methods: We retrospectively reviewed SCLC patients with CNS metastases confirmed by brain magnetic resonance imaging (MRI).

10.3% Efficient Green Cd-Free Cu ZnSnS Solar Cells Enabled by Liquid-Phase Promoted Grain Growth.

Small grain size and near-horizontal grain boundaries are known to be detrimental to the carrier collection efficiency and device performance of pure-sulfide Cu ZnSnS (CZTS) solar cells. However, forming large grains spanning the absorber layer while maintaining high electronic quality is challenging particularly for pure sulfide CZTS. Herein, a liquid-phase-assisted grain growth (LGG) model that enables the formation of large grains spanning across the CZTS absorber without compromising the electronic quality is demonstrated.

Epidemiological investigation and prevention and control strategies of rubella in Anhui province, China, from 2012 to 2021.

Background: Rubella is a highly contagious viral infection with mild manifestations that occurs most often in children and young adults. Infection during pregnancy, especially during the first trimester, can result in an infant born with congenital rubella syndrome (CRS). The purpose of this paper is to analyze the characteristics of rubella epidemics in Anhui province from 2012 to 2021 and explore the prevention and control strategies of rubella.

A metal-organic framework derived approach to fabricate in-situ carbon encapsulated Bi/BiO heterostructures as high-performance anodes for potassium ion batteries.

Bismuth-based materials are regarded as promising anode materials for potassium ion batteries (PIBs) due to their high theoretical capacity and low working potential. However, the large volume expansion and sluggish kinetics during cycling are major limitations to their practical application. Herein, a unique Bi/BiO-C heterostructure was designed through a simple Bi-metal-organic framework (MOF) modulation-pyrolysis process.

Efficacy of immune checkpoint inhibitor therapy in EGFR mutation-positive patients with NSCLC and brain metastases who have failed EGFR-TKI therapy.

Background: Few treatment options are available for brain metastases (BMs) in EGFR-mutant non-small cell lung cancer (NSCLC) that progress with prior EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy. This study aimed to evaluate the efficacy of immune checkpoint inhibitor (ICI) therapy in these patients.

Methods: NSCLC patients with confirmed sensitive EGFR mutations and BMs were retrospectively reviewed.

Transmission Pattern of Measles Virus Circulating in China During 1993-2021: Genotyping Evidence Supports That China Is Approaching Measles Elimination.

Background: To provide useful insights into measles elimination progress in China, measles surveillance data were reviewed, and the transmission patterns of measles viruses circulating in China during 1993-2021 were analyzed.

Methods: Measles incidence data from the National Notifiable Disease Reporting System of the China Center for Disease Control and Prevention were analyzed. A total of 17 570 strains were obtained from 30 of 31 provinces in mainland China during 1993-2021.

TIGIT blockade enhances tumor response to radiotherapy via a CD103 + dendritic cell-dependent mechanism.

Blockade of the T cell immunoreceptor with the immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) can enhance innate and adaptive tumor immunity and radiotherapy (RT) can enhance anti-tumor immunity. However, our data suggest that TIGIT-mediated immune suppression may be an impediment to such goals. Herein, we report on the synergistic effects of RT combined with anti-TIGIT therapy and the mechanism of their interaction.

Photo-electrochemical oxidation herbicides removal in stormwater: Degradation mechanism and pathway investigation.

Although advanced oxidation processes (AOPs) such as photoelectrochemical oxidation (PECO), electrochemical oxidation (ECO) and photocatalytic oxidation (PCO), have shown potential for wastewater treatment, their application in urban stormwater has rarely been studied. This paper explored their major degradation mechanisms and possible degradation pathways of herbicides for stormwater applications (with treatment difficulty compared with wastewater). PECO and ECO showed excellent removal performance for diuron (100 %) and moderate for atrazine (around 35 %) under a relatively low potential (2 V).

Engineering a Kesterite-Based Photocathode for Photoelectrochemical Ammonia Synthesis from NO Reduction.

Ammonia is a key chemical feedstock for industry as well as future carbon-free fuel and transportable vector for renewable energy. Photoelectrochemical (PEC) ammonia synthesis from NO reduction reaction (NO RR) provides not only a promising alternative to the energy-intensive Haber-Bosch process through direct solar-to-ammonia conversion, but a sustainable solution for balancing the global nitrogen cycle by restoring ammonia from wastewater. In this work, selective ammonia synthesis from PEC NO RR by a kesterite (Cu ZnSnS [CZTS]) photocathode through loading defect-engineered TiO cocatalyst on a CdS/CZTS photocathode (TiO /CdS/CZTS) is demonstrated.

Effects of the IQ1 motif of Drosophila myosin-5 on the calcium interaction of calmodulin.

In Drosophila compound eyes, myosin-5 (DmMyo5) plays a key role in organelle transportation, including transporting pigment granules from the distal end to the proximal end of the photoreceptor cells to regulate the amount of light reaching the photosensitive membrane organelle rhabdomere. It is generally accepted that, upon exposure to light, the dark-adapted compound eyes produce a rapid rise of free Ca concentration, which in turn activates DmMyo5 to transport pigment granules. Considering the dynamic and compartmentation of Ca signaling in photoreceptor cells during light exposure, it is necessary to understand the kinetics of Ca interaction with DmMyo5.

Microbe-derived antioxidants attenuate cobalt chloride-induced mitochondrial function, autophagy and BNIP3-dependent mitophagy pathways in BRL3A cells.

Environmental excessive cobalt (Co) exposure increases risks of public health. This study aimed to evaluate the potential mechanism of microbe-derived antioxidants (MA) blend fermented by probiotics in attenuating cobalt chloride (CoCl)-induced toxicology in buffalo rat liver (BRL3A) cells. Herein, results showed that some phenolic acids increased in MA compared with the samples before fermentation through UHPLC-QTOF-MS analysis.

Accelerating Electron-Transfer and Tuning Product Selectivity Through Surficial Vacancy Engineering on CZTS/CdS for Photoelectrochemical CO Reduction.

Copper-based chalcogenides have been considered as potential photocathode materials for photoelectrochemical (PEC) CO reduction due to their excellent photovoltaic performance and favorable conduction band alignment with the CO reduction potential. However, they suffer from low PEC efficiency due to the sluggish charge transfer kinetics and poor selectivity, resulting from random CO reduction reaction pathways. Herein, a facile heat treatment (HT) of a Cu ZnSnS (CZTS)/CdS photocathode is demonstrated to enable significant improvement in the photocurrent density (-0.

The landscape of bispecific T cell engager in cancer treatment.

T cell-based immunotherapies have revolutionized treatment paradigms in various cancers, however, limited response rates secondary to lack of significant T-cell infiltration in the tumor site remain a major problem. To address this limitation, strategies for redirecting T cells to treat cancer are being intensively investigated, while the bispecific T cell engager (BiTE) therapy constitutes one of the most promising therapeutic approaches. BiTE is a bispecific antibody construct with a unique function, simultaneously binding an antigen on tumor cells and a surface molecule on T cells to induce tumor lysis.