The pH-sensitive chondroitin sulphate-based nanoparticles for co-delivery of doxorubicin and berberine enhance the treatment of breast cancer.

In the tumor microenvironment (TME), cancer associated fibroblasts (CAFs) facilitate drug resistance and tumor metastasis. Therefore, more and more attention has been focused on the regulation of TME by preventing the cross-talk between tumor cells and CAFs in the treatment of breast cancer. In this study, we have combined the benefits of deep drug penetration, pH sensitivity, and tumor-targeting delivery to prepare chondroitin sulphate (CS)-based nanomicelles (BBR/CS-DOX) for the co-delivery of doxorubicin (DOX) and berberine (BBR).

Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity.

Acori Tatarinowii Rhizoma (ATR) is a well-known traditional Chinese medicine that is used for treating neuropathic diseases. However, there is little information about the safety of ATR. The present study evaluated the acute and subacute oral toxicity of a water extract of ATR in Institute of Cancer Research (ICR) mice.

Taste dysfunction as a predictor of depression in schizophrenia: A systematic review and meta-analysis.

Objective: This study aims to investigate the relationship between taste dysfunction and depression among patients with schizophrenia, to achieve early detection of depression in clinical practice.

Methods: Following PRISMA guidance, a comprehensive literature search was conducted globally, covering papers published from 1961 to June 2023. A total of 17 manuscripts were selected through meta-analysis and sensitivity analysis after examining available materials from seven databases to determine the correlation between depression and taste dysfunction.

Ferric citrate for the treatment of hyperphosphatemia and iron deficiency anaemia in patients with NDD-CKD: a systematic review and meta-analysis.

The application of ferric citrate therapy has yielded unexpected benefits in recent years for Chronic kidney disease patients suffering from hyperphosphatemia and iron deficiency -anaemia. Despite this, earlier research on the impact of ferric citrate on NDD-CKD has been contentious. The goal of the meta-analysis is to evaluate the evidence regarding the advantages and dangers of ferric citrate for the treatment of hyperphosphatemia and iron deficiency anaemia in NDD-CKD patients.

Anti-tumor therapy of glycyrrhetinic acid targeted liposome co-delivery of doxorubicin and berberine for hepatocellular carcinoma.

During the development of hepatocellular carcinoma (HCC), hepatic stellate cells undergo activation and transform into cancer-associated fibroblasts (CAFs) due to the influence of tumor cells. The interaction between CAFs and tumor cells can compromise the effectiveness of chemotherapy drugs and promote tumor proliferation, invasion, and metastasis. This study explores the potential of glycyrrhetinic acid (GA)-modified liposomes (lip-GA) as a strategy for co-delivery of berberine (Ber) and doxorubicin (Dox) to treat HCC.

Coupling and coordinated development of low-carbon economy and green finance: an empirical study of the Yangtze River Delta region in China.

The introduction of China's double carbon target has led to a new stage in the development of China's low-carbon economy, while the development of China's green finance is also facing new challenges. Based on the determining of the relationship between low-carbon economy and green finance, this study selected the Yangtze River Delta city cluster of China, an exemplary region for the development of low-carbon economy and green finance, constructed a multi-level comprehensive index system covering two systems of low-carbon economy and green finance and conducted a coupled and coordinated relationship analysis based on the panel data of green finance and low-carbon economy-related indicators from 2016 to 2020. The empirical results showed that the interaction between the low-carbon economy system and the green finance system in the Yangtze River Delta region gradually weakened during 2016-2020, and the mechanism of interaction between the two systems has not been fully developed and utilized.

Dynamic changes in three biomarkers predict early-stage hepatocellular carcinoma in patients with chronic hepatitis B receiving antiviral therapy.

Purpose: Patients with chronic hepatitis B (CHB) remain at risk for hepatocellular carcinoma during antiviral therapy. We aimed to clarify the values of alpha-fetoprotein (AFP), lectin-reactive fraction of AFP (AFP-L3), and des-γ-carboxyprothrombin (DCP) for early warning of HCC.

Methods: A total of 1348 CHB patients received antiviral therapy and follow-up every 26 weeks.

Spatiotemporal evolution and influencing factors of land-use emissions in the Guangdong-Hong Kong-Macao Greater Bay Area using integrated nighttime light datasets.

Carbon emissions from land-use and land-cover change (together referred to as 'land-use emissions') are an important way to influence the regional carbon balance. However, due to the limitations and complexity of obtaining carbon emissions data at spatial scales, previous studies rarely reveal the long-term evolution characteristics of regional land-use emissions. Therefore, we propose a method to integrate DMSP/OLS and NPP/VIIRS nighttime light images to calculate land-use emissions over a long time series.

Spatio-temporal evolution and gravity center change of carbon emissions in the Guangdong-Hong Kong-Macao greater bay area and the influencing factors.

The Guangdong-Hong Kong-Macao Greater Bay Area (GBA) is one of the most densely built and economically vibrant regions in China, it is of vital importance to study the spatio-temporal heterogeneity and influence mechanisms of its carbon emissions against the backdrop of peaking carbon dioxide emissions and achieving carbon neutrality. However, systematic research on this area is still lacking. Therefore, this study uses spatial autocorrelation, kernel density estimation, and standard deviation ellipses to construct an exploratory spatial data analysis (ESDA) framework to analyze the spatio-temporal evolutionary characteristics of carbon emissions from GBA and combine it with the geographically and temporally weighted regression (GTWR) model to identify the various influencing factors of carbon emissions in GBA and reveal its implications.

Repair effect of photobiomodulation combined with human umbilical cord mesenchymal stem cells on rats with acute lung injury.

Acute lung injury (ALI) impaired the function of blood oxygen exchange function, resulting in tissue hypoxia and patient death. Recently, human umbilical cord mesenchymal stem cells (hUCMSCs) are thought to mitigate the effects of ALI, which boosts researchers' interest in employing stem cell-based therapies to manage ALI. However, as a novel therapy, hUCMSCs still face various limitations such as migrating weakly and insufficient proliferation in vivo.

Effects of Residential Environment and Lifestyle on Atopic Eczema Among Preschool Children in Shenzhen, China.

Eczema, one of the most prevalent inflammatory skin diseases among children, is potentially influenced by genetic, environmental and social factors. However, few studies have investigated the effect of residential environment and lifestyle on childhood eczema. Therefore, this study conducted a cross-sectional study based on 2,781 preschool children in Shenzhen, China, during 2015-2016.

Stereotactic Aspiration Acts as an Effective Treatment for Malignant Middle Cerebral Artery Infarction.

Objective: This study seeks to explore the efficacy and prognosis of stereotactic aspiration for malignant middle cerebral artery infarction (mMCAI).

Methods: A total of 50 mMCAI patients who were diagnosed and treated in our hospital from January 2018 to June 2020 were collected and then randomly divided into control group (decompressive craniectomy,  = 24) and study group (stereotactic aspiration,  = 26). After 1 and 6 months of treatment, the scores of the National Institutes of Health Stroke Scale (NIHSS), Glasgow Coma Scale (GCS), Barthel Index, and modified Rankin Scale (mRS) were used to evaluate the therapeutic effect.

Minimally Invasive Surgery for Intracerebral and Intraventricular Hemorrhage.

Spontaneous intracerebral hemorrhage (ICH), especially related to intraventricular hemorrhage (IVH), is the most devastating type of stroke and is associated with high mortality and morbidity. Optimal management of ICH remains one of the most controversial areas of neurosurgery and no effective treatment exists for ICH. Studies comparing conventional surgical interventions with optimal medical management failed to show significant benefit.

Early Perihematomal Edema Expansion: Definition, Significance, and Association with Outcomes after Intracerebral Hemorrhage.

Objective: To investigate the association between early perihematomal edema (PHE) expansion and functional outcome in patients with intracerebral hemorrhage (ICH).

Methods: Patients with ICH who underwent initial computed tomography (CT) scans within 6 hours after the onset of symptoms and follow-up CT scans within 24 ± 12 hours were included. Absolute PHE increase was defined as the absolute increase in PHE volume from baseline to 24 hours.

High Oxygen Evolution Activity of Tungsten Bronze Oxides Boosted by Anchoring of Co at Nb Sites Accompanied by Substantial Oxygen Vacancy.

The participation of lattice oxygen in the oxygen evolution reaction (OER) process has been proved to be faster in kinetics than the mechanisms where only metal is involved, although activating the lattice oxygen in the traditional rigid structures remains a big challenge. In this work, efforts are devoted to exploring a new flexible structure that is competent in providing large amounts of oxygen vacancies as well as offering the freedom to manipulate the electronic structure of metal cations. This is demonstrated by anchoring low valence state Co at high valence state Nb sites in the tetragonal tungsten bronze (TTB)-structured SrBaNb Co O , with different ratios of Co to Nb to optimize the Co substitution proportion.

FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2-mediated glycolysis.

FoxA2 is an essential transcription factor for liver organogenesis and homeostasis. Although reduced expression of FoxA2 has been associated with chronic liver diseases, hepatic progenitor cells (HPCs) that are activated in these circumstances express FoxA2. However, the functional effects and underlying mechanism of FoxA2 in HPCs are still unknown.

Long non-coding RNA NEAT1 promotes human glioma tumor progression via miR-152-3p/CCT6A pathway.

Background: Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) has been documented to implicate in diverse tumor progression. However, the mechanism of NEAT1 in glioma was rarely reported.

Methods: The levels of NEAT1, microRNA-152-3p (miR-152-3p) and chaperonin containing TCP1 subunit 6A (CCT6A) in glioma tissues and cells were measured by quantitative real-time polymerase chain reaction (qRT-PCR).

EGF neutralization antibodies attenuate liver fibrosis by inhibiting myofibroblast proliferation in bile duct ligation mice.

The expression of epidermal growth factor (EGF) is increased during liver fibrogenesis, and EGF receptor (EGFR) antagonist could attenuate liver fibrosis. Since EGFR is highly expressed by hepatocytes and cholangiocytes in cirrhotic liver, whether hepatic stellate cells express EGFR in response to EGF still needs exploration. Although EGFR antagonist could attenuate liver fibrosis, many ligands with EGF-like domains, besides EGF, can function through EGFR.

Stereotactic Aspiration of Necrotic Brain Tissue for Treating Malignant Middle Cerebral Artery Infarction: A Report of 13 Consecutive Cases.

Background: This study aimed to evaluate the efficacy and safety of stereotactic aspiration of necrotic brain tissue for treating malignant middle cerebral artery infarction (MMI) in patients older than 60 years of age.

Case Description: A total of 13 consecutive patients with MMI (mean age, 67 ± 6.62 years) were enrolled in the study.

Nanoscale Structural Modulation and Low-temperature Magnetic Response in Mixed-layer Aurivillius-type Oxides.

Nanoscale structural modulation with different layer numbers in layer-structured complex oxides of the binary BiTiO-BiFeO system can give rise to intriguing phenomena and extraordinary properties, originating from the correlated interfaces of two different phases with different strain states. In this work, we studied the nanoscale structural modulation induced by Co-substitution in the Aurivillius-type oxide of BiFeTiO with a unique and naturally occurred mixed-layer structure. Nanoscale structural evolution via doping occurred from the phase-modulated structure composed of 4- and 5-layer phases to a homogeneous 4-layer structure was clearly observed utilizing x-ray diffraction and electron micro-techniques.

Additive-Enhanced Crystallization of Solution Process for Planar Perovskite Solar Cells with Efficiency Exceeding 19 .

To reduce intrinsic defect density in perovskite films, various additives are often added into the precursor solution. In this paper, a novel solution, in which isopropanol (IPA) was added into the precursor solution, was developed for the preparation of normal planar perovskite solar cells (PSCs). A champion power conversion efficiency (PCE) of 19.

Intrinsic multiferroics in an individual single-crystalline BiFeCoTiO nanoplate.

In recent years, much attention has been paid to layer-structured BiBiFeMTiO (BFMTO, M = Co, Mn) compounds due to their potential as high temperature single phase multiferroic materials. However, BFMTO single crystals have been rarely reported in the past, though they are better candidates for studying the corresponding intrinsic multiferroics as well as the platform for making future devices, due to their structural complexity and difficulties in fabrication. In this article, BiFeCoTiO single-crystalline nanoplates were synthesized by the hydrothermal method.

Post-operative re-bleeding in patients with hypertensive ICH is closely associated with the CT blend sign.

Backgrounds: Intracranial post-operative re-haemorrhage is an important complication in patients with hypertensive intracerebral haemorrhage (ICH). The purpose of the present study was to determine the value of the computed tomography (CT) blend sign in predicting post-operative re-haemorrhage in patients with ICH.

Methods: A total of 126 patients with ICH were included in the present study.

Engineering the exchange bias and bias temperature by modulating the spin glassy state in single phase BiFeTiO.

Exchange anisotropy is normally observed at ferromagnetic (FM)/anti-ferromagnetic (AFM) interfaces and also usually at low temperatures. An effective way to find new single-phase materials with strong exchange bias (EB) and high operation temperatures is required for making them useful in practical applications of future spintronic devices. In this work, the exchange bias behaviors of single phase BiFeTiO (BFT) were found able to be manipulated by altering its spin glassy state, when the material was intentionally prepared in the nanobelt format.