Publications by authors named "Shujie Lu"
3-Fucosyllactose (3-FL), an essential component of human milk oligosaccharides, is crucial for infant health. However, the extraction of 3-FL from milk presents a significant challenge. In this study, BL21 Star (DE3) was engineered for 3-FL biosynthesis, and the gene combinations and metabolic pathways were optimized to obtain a high-yield 3-FL production strain.
View Article and Find Full Text PDFArticle Synopsis
- Topology is the study of properties that remain unchanged under continuous transformations, and the concept of genus, or the number of pores, is important in characterizing microscopic systems, though it hasn't been thoroughly explored in macroscopic materials.
- The paper introduces a new method using a boric acid ester cross-linking strategy to quickly observe topological changes during the transition from droplets to rings in microgels.
- It also examines how these topological changes impact the electrical properties of macroscopic materials, suggesting that understanding topology can help in designing advanced materials with specific characteristics.
Article Synopsis
- - The study aimed to compare the effectiveness and safety of efdamrofusp alfa with aflibercept in treating neovascular age-related macular degeneration (nAMD) through a randomized phase II trial involving 231 participants.
- - Participants received either efdamrofusp alfa or aflibercept, with treatments administered monthly for the first three doses and then every eight weeks, measuring visual acuity changes over 52 weeks.
- - Results showed that efdamrofusp alfa was as effective as aflibercept in improving vision, with similar rates of adverse effects, establishing its noninferiority in treatment outcomes.
Although some progress has been made in the treatment of cancer, challenges remain. In recent years, advancements in nanotechnology and stem cell therapy have provided new approaches for use in regenerative medicine and cancer treatment. Among them, magnetic nanomaterials have attracted widespread attention in the field of regenerative medicine and cancer; this is because they have high levels of safety and low levels of invasibility, promote stem cell differentiation, and affect biological nerve signals.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed the safety, tolerability, and effectiveness of efdamrofusp alfa in patients with neovascular age-related macular degeneration (nAMD) through a phase 1b clinical trial involving patients over 50 years old.
- It compared two doses of efdamrofusp alfa (2 mg and 4 mg) against aflibercept (2 mg) using intravitreal injections and tracked outcomes like visual acuity and CNV area changes over 20 weeks.
- The results showed no serious adverse effects, with overall visual improvements observed in patients receiving both efdamrofusp alfa and aflibercept, indicating potential benefits of efdamrofusp alfa in treating nAMD.
Antiangiogenesis therapies targeting vascular endothelial growth factor (VEGF) have revolutionized the treatment of neovascular ocular diseases, including neovascular age-related macular degeneration (nAMD). Compelling evidence has implicated the vital role of complement system dysregulation in AMD pathogenesis, implying it as a potential therapeutic strategy for geographic atrophy in dry AMD and to enhance the efficacy of anti-VEGF monotherapies in nAMD. This study reports the preclinical assessment and phase 1 clinical outcomes of a bispecific fusion protein, efdamrofusp alfa (code: IBI302), which is capable of neutralizing both VEGF isoforms and C3b/C4b.
View Article and Find Full Text PDFGenetic Algorithm for TMS Coil Position Optimization in Stroke Treatment.
Front Public Health
April 2022
Article Synopsis
- * Accurate coil placement is crucial for the effectiveness of TMS, but current methods have significant errors, necessitating improved positioning techniques.
- * This study developed a genetic algorithm-based optimization method to determine the best coil location and angle, achieving up to 17.48% higher electric field intensity in targeted areas compared to traditional approaches, while reducing unnecessary exposure to non-target regions.
Background: The commonly used NEMA IEC Body phantom has a number of defects, hindering its application for detecting micro-lesions and measuring the performance parameters of computed tomography (CT). This study aimed to propose a PET/CT phantom designed by National Institute of Metrology (NIM), China, which is capable of simultaneously testing the performance of PET and CT systems, and to evaluate the quality of imaging.
Methods: The phantom developed in the present study, the NIM PET/CT phantom, is composed of a PET imaging module and a CT imaging module, and these modules are connected together through bolts, which can simultaneously measure the imaging performance of PET and CT systems.
Background: China approved adalimumab for the treatment of ankylosing spondylitis in 2013. However, the cost of the standard dose regimen exceeds ¥15 000 (around US$2250) per month, which is well beyond affordability for most Chinese patients. No biosimilars of adalimumab are available in China; IBI303 is a monoclonal antibody against TNFα that is currently in development.
View Article and Find Full Text PDFObjective: To study the direct effect of hawthorn leaf procyanidins on cardiomyocytes subjected to ischemia-reperfusion injury and elucidate their therapeutic mechanism on ischemic heart diseases.
Method: Cultured cardiomyocytes of neonatal rats were subjected to anoxia-reoxia injury which simulated the ischemia-reperfusion injury in vivo, and hawthorn leaf procyanidins were applied. The therapeutic effect was valued by LDH leakage and MTT test.