Publications by authors named "Shujia Lin"
Cystathionine γ-lyase (CSE) is a major enzyme that produces hydrogen sulfide (HS). Herein, we report how CSE plays a previously unknown role in regulating the antioxidant effects of the mitochondria in human umbilical vein endothelial cells by releasing HS nearby under stress conditions. We found that HS partially promoted angiogenesis in the endothelial cells through the AKT/nuclear factor erythroid 2-related factor 2 (AKT/NRF2) signaling pathway.
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- * The study evaluated ChatGPT-4V's diagnostic abilities through three methods, including USMLE-style questions, assessment of chest radiography abnormalities, and complex case diagnoses, yielding varied results.
- * ChatGPT-4V showed a diagnostic accuracy of 77.01% for USMLE questions, but its accuracy dropped significantly to 19.54% without detailed patient history, highlighting the importance of comprehensive data for effective diagnoses.
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a hereditary heart disease characterized by bidirectional or polymorphic ventricular tachycardia and an increased risk of sudden cardiac death. Although trans-2,3-enoyl-CoA reductase like () is a newly reported pathogenic gene leading to CPVT that can influence intracellular calcium regulation, the unidentified mechanism underlying the pathogenesis of TECRL deficiency-mediated CPVT remains mainly elusive. In the present study, knockout (KO) mice were established and the differentially expressed genes (DEGs) were investigated by RNA-sequencing from the heart tissues.
View Article and Find Full Text PDFSerum Metabolomic Profile in Hypoxia-Induced Pulmonary Hypertension Mice after C75 Treatment.
Front Biosci (Landmark Ed)
October 2023
Article Synopsis
- * Metabolomic analysis revealed 29 unique metabolites in hypoxia mice, and 15 additional metabolites were found after C75 treatment; these were linked to cell proliferation and enriched in metabolism pathways relating to arginine and glycerolipid.
- * In pediatric PH patients, elevated levels of glutamine and caproyl carnitine were observed, suggesting that FAS could be a promising therapeutic target and identifying putrescine and glutamine as potential biomarkers for PH.
The Emerging Role of Fatty Acid Synthase in Hypoxia-Induced Pulmonary Hypertensive Mouse Energy Metabolism.
Oxid Med Cell Longev
September 2021
Aims: This study is aimed at examining whether fatty acid synthase () can regulate mitochondrial function in hypoxia-induced pulmonary arterial hypertension (PAH) and its related mechanism.
Results: The expression of significantly increased in the lung tissue of mice with hypoxia-induced PAH, and its pharmacological inhibition by C75 ameliorated right ventricle cardiac function as revealed by echocardiographic analysis. Based on transmission electron microscopy and Seahorse assays, the mitochondrial function of mice with hypoxia was abnormal but was partially reversed after C75 injection.