Surrogate-assisted global and distributed local collaborative optimization algorithm for expensive constrained optimization problems.

This paper presents a surrogate-assisted global and distributed local collaborative optimization (SGDLCO) algorithm for expensive constrained optimization problems where two surrogate optimization phases are executed collaboratively at each generation. As the complexity of optimization problems and the cost of solutions increase in practical applications, how to efficiently solve expensive constrained optimization problems with limited computational resources has become an important area of research. Traditional optimization algorithms often struggle to balance the efficiency of global and local searches, especially when dealing with high-dimensional and complex constraint conditions.

Quantum critical dynamics in a 5,000-qubit programmable spin glass.

Experiments on disordered alloys suggest that spin glasses can be brought into low-energy states faster by annealing quantum fluctuations than by conventional thermal annealing. Owing to the importance of spin glasses as a paradigmatic computational testbed, reproducing this phenomenon in a programmable system has remained a central challenge in quantum optimization. Here we achieve this goal by realizing quantum-critical spin-glass dynamics on thousands of qubits with a superconducting quantum annealer.

Scaling advantage over path-integral Monte Carlo in quantum simulation of geometrically frustrated magnets.

The promise of quantum computing lies in harnessing programmable quantum devices for practical applications such as efficient simulation of quantum materials and condensed matter systems. One important task is the simulation of geometrically frustrated magnets in which topological phenomena can emerge from competition between quantum and thermal fluctuations. Here we report on experimental observations of equilibration in such simulations, measured on up to 1440 qubits with microsecond resolution.

Intravenous propofol precipitates the hypotension induced by inadvertent epidural thiopental injection.

Administration of improper drugs into epidural space is occasionally present in anesthetic practice. In most instances it would not contribute to significant neurological complications. There had not been severe hypotension reported in the literature in consequence of inadvertent epidural thiopental administration.