Optimized Design of Solid-Liquid Dual-Impeller Mixing Systems for Enhanced Efficiency.

Flow interferences occur in the dual-impeller stirred tank between paddles as well as between paddles and baffles and the tank wall, leading to inefficient utilization of the stirring energy. To address this issue, this study investigates the flow characteristics within the mixing tank using Euler-Euler numerical simulation and the particle image velocimetry (PIV) experimental method. The three-dimensional nonconstant flow characteristics are analyzed to optimize the critical stirrer geometry.

Development of a bioactive silk fibroin bilayer scaffold for wound healing and scar inhibition.

In cases of deep skin defects, spontaneous tissue regeneration and excessive collagen deposition lead to hyperplastic scars. Conventional remedial action after scar formation is limited with a high recurrence rate. In this study, we designed a new artificial skin bilayer using silk fibroin nanofibers films (SNF) as the epidermis, and silk fibroin (SF) / hyaluronic acid (HA) scaffold as the dermal layer.

Advances in Skin Wound and Scar Repair by Polymer Scaffolds.

Scars, as the result of abnormal wound-healing response after skin injury, may lead to loss of aesthetics and physical dysfunction. Current clinical strategies, such as surgical excision, laser treatment, and drug application, provide late remedies for scarring, yet it is difficult to eliminate scars. In this review, the functions, roles of multiple polymer scaffolds in wound healing and scar inhibition are explored.

Application of an ultrahigh-performance liquid chromatography coupled to quadrupole-orbitrap high-resolution mass spectrometry for the rapid screening, identification and quantification of illegal adulterated glucocorticoids in herbal medicines.

In this work, the ultrahigh-performance liquid chromatography quadrupole orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was applied to the rapid screening, identification and quantification of the illegal adulterated glucocorticoids in herbal medicines. The mass spectrometer was operated in positive ion mode and Full MS/dd-MS (data-dependent MS) mode, where selected ions were subjected to a dd-MS scan with given fragmentation energy following a Full MS scan. The application of 70 000 FWHM mass resolution and narrow mass windows (5ppm) effectively improve the selectivity of the method, and a single injection was sufficient to perform the simultaneous screening and identification/quantification of 14 glucocorticoids in 15min.