Feasibility of major hepatectomy following preoperative chemotherapy for advanced perihilar cholangiocarcinoma.

Background: The safety of major hepatectomy following preoperative chemotherapy for perihilar cholangiocarcinoma (PHCC) is underexplored. This study evaluates the impact of preoperative chemotherapy on surgical outcomes and assesses chemotherapy-induced liver injury in patients with advanced PHCC.

Methods: This retrospective study included 62 PHCC patients who underwent surgery between January 2019 and January 2024.