Publications by authors named "Shui Wa Yun"
Background: Gastric intestinal metaplasia (IM) is a precancerous stage spanning a morphological spectrum that is poorly represented by human cell line models.
Objective: We aim to establish and characterise human IM cell models to better understand IM progression along the cancer spectrum.
Design: A large human gastric IM organoid (IMO) cohort (n=28), their clonal derivatives and normal gastric organoids (n=42) for comparison were established.
Article Synopsis
- Cell-cell (CC) and cell-matrix (CM) adhesions are crucial for epithelial cell survival, but many gastric cancer (GC) organoids exhibit resistance to apoptosis when these attachments are disrupted.
- In a study of 58 GC organoids, researchers found that a majority were either resistant to both CC and CM withdrawal or showed an independence from these adhesions, correlating with advanced tumor stages and poor patient outcomes.
- The dysregulation of RHO signaling pathways was implicated in this resistance, suggesting that targeting these mechanisms could provide new therapeutic strategies for combating gastric cancer progression.