Publications by authors named "Shui Fan Lai"
Introduction: Low vitamin D status is prevalent among women with polycystic ovary syndrome (PCOS). The objective of the study is to assess the effect of vitamin D supplementation on (1) the ovulation rate to letrozole and (2) other reproductive, endocrine and metabolic outcomes after 1 year of supplementation in women with PCOS.
Methods And Analysis: This is a multicentre, randomised, double-blind, controlled clinical trial.
Purpose: This study aimed to optimize the non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) in the laboratory by comparing two collection timing of the spent culture medium (SCM), two embryo rinsing protocols, and the use of conventional insemination instead of intracytoplasmic sperm injection (ICSI).
Methods: Results of two embryo rinsing methods (one-step vs sequential) and SCM collected on day 5 vs day 6 after retrieval were compared against trophectoderm (TE) biopsies as reference. Results from day 6 SCM in cycles fertilized by conventional insemination were compared with PGT-A using ICSI.
Introduction: The success rate of in vitro fertilisation (IVF) treatment for couples with infertility remains low due to lack of a reliable tool in selecting euploid embryos for transfer. This study aims to compare the efficacy in embryo selection based on morphology alone compared with non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) and morphology in infertile women undergoing IVF.
Methods And Analysis: This is a randomised double-blind controlled trial conducted in two tertiary assisted reproduction centres.
Objective: To compare the effects of hyaluronic acid (HA)-enriched transfer medium versus standard medium on live birth rate after frozen embryo transfer (FET).
Design: Randomized, double-blind, controlled trial.
Setting: Two tertiary fertility centers.
Article Synopsis
- The study investigated whether oral progestogen could reduce miscarriage rates in women experiencing threatened miscarriage during their first trimester compared to a placebo.
- The results indicated that there was no significant difference in miscarriage rates before 20 weeks, with 12.8% in the progestogen group and 14.3% in the placebo group.
- Overall, the use of oral progestogen did not improve outcomes in these cases, aligning with previous findings regarding vaginal progestogens.
Research Question: Is fentanyl and midazolam non-inferior to pethidine and diazepam in pain relief during oocyte retrieval under conscious sedation?
Design: A randomized double-blinded non-inferiority trial of 170 infertile women undergoing oocyte retrieval under conscious sedation in an assisted reproduction centre. The women were randomized to receive intravenously either 0.1 mg fentanyl and 5 mg midazolam or 25 mg pethidine and 5 mg diazepam, plus paracervical block with 10 ml 1% lignocaine.