Neohesperidin protects against colitis-associated colorectal cancer in mice via suppression of the NF-κB/p65 and MAPK pathways.

Patients with inflammatory bowel disease (IBD) are at increased risk of developing colitis-associated colorectal cancer (CAC). Neohesperidin (NHP), a flavanone glycoside derived from citrus fruits, has been reported to have anti-inflammatory, antioxidant, and anticancer potential. However, the function of NHP on tumorigenesis has not been well understood.

Penehyclidine hydrochloride improves cognitive function of rats with brain injury via CAMP/CREB signaling pathway.

This study explored the impact of penehyclidine hydrochloride on cognitive function in rats with brain injury. Sprague-Dawley rats (n=36) were randomly assigned to sham-operation, model, and penehyclidine hydrochloride groups. Rats in the sham-operation group underwent craniotomy, while the model and penehyclidine hydrochloride groups received brain injury models and interventions with normal saline and penehyclidine hydrochloride, respectively.

[Chemical Composition and Characterization of Nitroaromatic Compounds in Urban Areas of Shanghai].

The compositional characteristics, concentration of nitroaromatic compounds(NACs) in PM in urban Shanghai, and their correlation with gaseous precursors were investigated. A total of 39 winter and 46 summer PM samples from 2020 to 2021 were collected using a high-flow sampler and analyzed via ultra-performance liquid chromatography coupled with ESI-Orbitrap high-resolution mass spectrometry(UPLC-Orbitrap-HRMS). Quantitative analysis was performed on 12 NACs compounds, combined with backward trajectory meteorological elements, molecular composition, and classification analysis of CHON substances.

[Chemical Characteristics and Source Apportionment of Organic Aerosols in Urban Shanghai During Cold Season Based on High Time-resolution Measurements of Organic Molecular Markers].

Organic aerosols (OA) are closely related to the formation of both PM and O in the atmosphere. In this study, a thermal desorption aerosol GC/MS (TAG) online system was adopted to measure hourly concentrations of 94 total organic molecular markers in PM at an urban site in Shanghai from November 6 to December 31, 2021. Combined with air mass cluster analysis and other online measurement data, the chemical characteristics of OA under the influence of different air masses, oxidant levels, and relative humidity (RH) levels were investigated.

Enigma of Urban Gaseous Oxygenated Organic Molecules: Precursor Type, Role of NO, and Degree of Oxygenation.

Oxidation of volatile organic compounds (VOCs) forms oxygenated organic molecules (OOMs), which contribute to secondary pollution. Herein, we present measurement results of OOMs using chemical ionization mass spectrometry with nitrate as the reagent ion in Shanghai. Compared to those in forests and laboratory studies, OOMs detected at this urban site were of relatively lower degree of oxygenation.

The interplays among meteorology, source, and chemistry in high particulate matter pollution episodes in urban Shanghai, China.

High particulate matter (PM) pollution episodes still occur occasionally in urban China, despite of improvements in recent years. Investigating the influencing factors of high-PM episodes is beneficial in the formulation of effective control measures. We herein present the effects of weather condition, emission source, and chemical conversion on the occurrence of high-PM episodes in urban Shanghai using multiple online measurements.

Hourly organic tracers-based source apportionment of PM before and during the Covid-19 lockdown in suburban Shanghai, China: Insights into regional transport influences and response to urban emission reductions.

During the Covid-19 outbreak, strict lockdown measures led to notable reductions in transportation-related emissions and significantly altered atmospheric pollution characteristics in urban and suburban areas. In this work, we compare comprehensive online measurements of PM major components and organic molecular markers in a suburban location in Shanghai, China before lockdown (Dec. 28, 2019 to Jan.

[Characteristics of Nitroaromatic Compounds in PM in Urban Area of Shanghai].

Nitroaromatic compounds (NACs) are an important class of nitrogen-containing compounds in fine particles. The investigation of characteristics and seasonal variation of NACs in PM increases our knowledge about nitrogen-containing compounds and contributes to the scientific basis in formulating reduction policies of NO in urban areas. In this study, we analyzed the chemical composition of PM samples collected from March 2018 to February 2019 in an urban location in Shanghai.

Comparative Assessment of Cooking Emission Contributions to Urban Organic Aerosol Using Online Molecular Tracers and Aerosol Mass Spectrometry Measurements.

Cooking organic aerosol (COA) is an important source of particulate pollutants in urbanized regions. Yet, the diversity and complexity of COA components make direct identification and quantification of COA difficult. In this study, we conducted collocated OA measurements with an aerosol mass spectrometer (AMS) and a thermal desorption aerosol gas chromatography-mass spectrometer (TAG) in Shanghai.

Estimation of Aromatic Secondary Organic Aerosol Using a Molecular Tracer-A Chemical Transport Model Assessment.

A modified community multiscale air quality model, which can simulate the regional distributions of 2,3-dihydroxy-4-oxopentanoic acid (DHOPA), a marker species for monoaromatic secondary organic aerosol (SOA), was applied to assess the applicability of using the DHOPA to aromatic SOA mass ratio () from smog chamber experiments to estimate aromatic SOA during a three-week wintertime air quality campaign in urban Shanghai. The modeled daily DHOPA concentrations based on the chamber-derived mass yields agree well with the organic marker field measurements ( = 0.79; MFB = 0.

Tracer-based characterization of source variations of PM and organic carbon in Shanghai influenced by the COVID-19 lockdown.

Air quality in megacities is significantly impacted by emissions from vehicles and other urban-scale human activities. Amid the outbreak of Coronavirus (COVID-19) in January 2020, strict policies were in place to restrict people's movement, bringing about steep reductions in pollution activities and notably lower ambient concentrations of primary pollutants. In this study, we report hourly measurements of fine particulate matter (i.

Adsorption of sulfonamides on biochars derived from waste residues and its mechanism.

Waste residues have been prepared as biochar (BC) adsorbents to remove sulfonamides (SAs) at low cost, but the mechanisms of the differences in the SA adsorption performance of different BCs are not clear. Thus, the adsorption characteristics of two SAs (sulfadiazine and sulfathiazole) on three BCs derived from waste residues (sewage sludge (SB), pig manure (PB), and rice straw (RB)) were investigated. The results showed that the adsorption mechanism was chemisorption and RB was the preferred BC under the different tested conditions (pH, Ca, and humic acid), followed by PB and SB.

[Audit Indicators and Suggested Ranges for Data Validation of Chemical Components in Ambient PM: A Case Study of the Yangtze River Delta].

Diagnostic indicators for the validation of PM compositional data were calculated, based on the monitoring results of approximately 2100 ambient samples collected in the Yangzi River Delta from 2014 to 2017. According to the results of a correlation analysis, we propose that the audit indexes of the monitoring data of PM components in ambient air should include:equivalent ratios of anion-cation charge balance(), the consistency between sum of all measured components(∑species) and weighed PM, the consistency between mass reconstructed PM(PM) and weighed PM, the chemical consistency between elemental S and water-soluble SO, elemental K and water-soluble K, and the chemical consistency of theoretical and tested NH. The double-sided 95% reference ranges of anion-cation equivalent balance (), ∑species/PM, PM/PM, S/SO, and K/K ratios were determined in terms of and as follows:(0.

Carcinogenic roles and therapeutic effects of EZH2 in gynecological cancers.

Enhancer of Zeste Homolog 2 (EZH2) is highly expressed in kinds of malignant tumors and related to tumor occurrence, development, and prognosis. EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which promotes cell proliferation, migration, and invasion by epigenetic regulation of anti-tumor gene. It can activate numerous tumor-associated signaling pathways and interfere with DNA damage repair.

Uptake and elimination of butyl- and phenyltins by Ceratophyllum demersum L.

The widespread occurrence and distribution of organotin compounds (OTCs) in both marine and freshwater ecosystems has aroused considerable concerns in most countries worldwide. In this work, individual kinetics of the elimination of three butyltins and three phenyltins from C. demersum L.

Relation of tributyltin and triphenyltin equilibrium sorption and kinetic accumulation in carp and Ceratophyllum demersum.

Comparatively limited knowledge is known about the accumulation processes of tributyltin (TBT) and triphenyltin (TPT) in fish and aquatic plant in the freshwater environment, which has hindered a full understanding of their bioaccumulation potential and ecological risks. In the present study, sorption of TBT and TPT on dead biota of both carp and C. demersum from water via the batch equilibrium technique as well as uptake of them on live biota of both carp and C.

[Physiochemical Properties of the Aerosol Particles and Their Impacts on Secondary Aerosol Formation at the Background Site of the Yangtze River Delta].

The study of the sources, compositions, and formation mechanisms of pollutants at the background site is crucial for the understanding of episodic events in the Yangtze River Delta (YRD). Secondary species are major components of PM particles. In this work, the compositions and concentrations of organic matter and secondary organic aerosol (SOA) at a background site of the YRD region were determined.

[Health Benefit Analyses of the Clean Air Action Plan Implementation in Shanghai].

To understand the public health benefits of the Clean Air Action Plan implemented in Shanghai from 2013-2017, the changes of the PM exposure levels and related health and economic benefits were quantitatively evaluated by using air quality numerical modeling, health risk assessment, and environmental valuation methods. The results show that the proportion of the population exposed to a mean annual PM concentration lower than or equal to 35 μg·m has increased from 1.62% in the base year to 34.

Intermediate Volatility Organic Compound Emissions from a Large Cargo Vessel Operated under Real-World Conditions.

Intermediate volatility organic compound (IVOC) emissions from a large cargo vessel were characterized under real-world operating conditions using an on-board measurement system. Test ship fuel-based emission factors (EFs) of total IVOCs were determined for two fuel types and seven operating conditions. The average total IVOC EF was 1003 ± 581 mg·kg-fuel, approximately 0.

An Integrated Source Apportionment Methodology and Its Application over the Yangtze River Delta Region, China.

An integrated source apportionment methodology is developed by amalgamating the receptor-oriented model (ROM) and source-oriented numerical simulations (SOM) together to eliminate the weaknesses of individual SA methods. This approach attempts to apportion and dissect the PM sources in the Yangtze River Delta region during winter. First, three ROM models (CMB, PMF, ME2) are applied and compared for the preliminary SA results, with information from PM sampling and lab analysis during the winter seasons.

[Analysis of Non-polar Organic Compounds in PM by Rapid Thermo-desorption Method Coupled with GC/MS].

Non-polar organic compounds (NPOCs) associated with PM in the atmosphere were analyzed by automated thermo-desorption (TD) coupled with gas chromatography/mass spectrometry (TD-GC/MS). The analyses for a total of 72 NPOCs were reviewed, including 34 PAHs, one Debenzothiophene, 27 alkanes (C-C), 5 hopanes and 5 steranes. Through this improved TD method, operation of filter loadings, TD condition and sample introduction were optimized.

Emission factors of particulate and gaseous compounds from a large cargo vessel operated under real-world conditions.

On-board emissions measurements were performed on a Handysize-class bulk carrier operating under real-world conditions. Emission factors (EFs) were determined for criteria pollutants such as NO, CO, total hydrocarbons (THC), and PM; PM composition, including organic and elemental carbon (OC and EC), inorganic species, and a variety of organic compounds and VOC species (including alkanes, alkenes, single-ring aromatics, and oxygenated VOCs) were also analyzed. To investigate the impacts of engine type, fuel, and operating conditions on emissions, measurements were conducted on one main and one auxiliary engines using low- and high-sulfur fuels (LSF and HSF) under actual operating conditions, including at-berth, maneuvering, and cruising at different engine loads.

[Chemical Characterization, Spatial Distribution, and Source Identification of Organic Matter in PM in summertime Shanghai, China].

Particulate organic matter (POM) has attracted increasing attention recently due to its great contribution to fine particles (PM) and complex components and sources. In the present study, 78 particulate organic compounds in PM were quantified at three sites in Shanghai during summer; these sites were located in urban (Xuhui), suburban (Qingpu), and coastal (Lin'gang) areas of the city. Accordingly, the chemical composition and spatial distribution were investigated and sources were explored based on the indicators and diagnostic ratios combined with backward trajectory.