DEHP-Induced Glioblastoma in Zebrafish Is Associated with Circadian Dysregulation of PER3.

DEHP is a plasticizer that is widely found in our water environment and poses a significant risk to the environment and human health. Long-term exposure to DEHP can cause endocrine disruption and interfere with the organism's normal functioning. In order to explore the potential effects of DEHP on the development of biological brain tissues, this study used bioinformatics analysis to confirm the diagnostic and prognostic value of PER3 in gliomas and further validated the neurotoxicity of DEHP using methods such as behavioral experiments and molecular biology in zebrafish.

Health risk assessment and development of human health ambient water quality criteria for PCBs in Taihu Basin, China.

Polychlorinated biphenyls (PCBs) are a class of typical persistent organic pollutants (POPs) with carcinogenicity and extensively found in diverse environmental mediums. The Taihu Basin is one of the most economically developed regions in China, and it has also caused a lot of historical legacy and unconscious emissions of PCBs, posing a threat to the health of people in the region. This study counted the concentrations of PCBs in five environmental media (water, soil, air, dust, and food) in the Taihu Basin from 2000 to 2020 and used Monte Carlo simulation to simulate the multi-channel exposure of PCBs in people of different ages (children, teenagers, and adults), and evaluated their noncarcinogenic and carcinogenic health risks.

The application of human-derived cell lines in neurotoxicity studies of environmental pollutants.

As industrial and societal advancements progress, an increasing number of environmental pollutants linked to human existence have been substantiated to elicit neurotoxicity and developmental neural toxicity. For research in this field, human-derived neural cell lines have become excellent in vitro models. This study examines the utilization of immortalized cell lines, specifically the SH-SY5Y human neuroblastoma cell line, and neural cells derived from human pluripotent stem cells, in the investigation of neurotoxicity and developmental neural toxicity caused by environmental pollutants.

Ecological risk assessment of 50 emerging contaminants in surface water of the Greater Bay Area, China.

Ecological risk assessment of emerging contaminants (ECs) is an international research hotspot and is also the focus of China's "14th Five-Year Plan". The Greater Bay Area (GBA) is one of the four major bay areas in the world and the most dynamic region in China. However, there are few studies on the risk assessment of ECs in the GBA, and there needs to be a systematic and comprehensive assessment of the ecological risk of ECs.

QSAR-QSIIR-based prediction of bioconcentration factor using machine learning and preliminary application.

Bioconcentration factor (BCF) is one of the important parameters for developing human health ambient water quality criteria (HHAWQC) for chemical pollutants. Traditional experimental method to obtain BCF is time-consuming and costly. Therefore, prediction of BCF by modeling has attracted much attention.

The Application of Reference Dose Prediction Model to Human Health Water Quality Criteria and Risk Assessment.

Oral reference dose (RfD) is a key parameter for deriving the human health ambient water quality criteria (AWQC) for non-carcinogenic substances. In this study, a non-experimental approach was used to calculate the RfD values, which explore the potential correlation between toxicity and physicochemical characteristics and the chemical structure of pesticides. The molecular descriptors of contaminants were calculated using T.

Chinese Technical Guideline for Deriving Water Quality Criteria for Protection of Freshwater Organisms.

In recent years, China has determined the national goal of "developing national environmental criteria", thereby promoting the rapid development of environmental quality criteria research in China. In 2017, the Ministry of Ecology and Environment of China (MEEC, formerly the Ministry of Environmental Protection of China) issued the technical guideline for deriving water quality criteria (WQC) for protection of freshwater organisms (HJ 831-2017), and in 2022, they organized the guideline revision and issued an updated version (HJ 831-2022). The primary contents of the revision included the following.

Reference dose prediction by using CDK molecular descriptors: A non-experimental method.

Reference dose (RfD) is an estimate of a daily dose that individual can be exposed chronically without obvious deleterious effects during a lifetime. In the area of toxicology, researchers always use the traditional approach by employing NOAEL/LOAEL or the benchmark dose (BMD) and other dose-response approaches to estimate RfD. These methods have, despite their typicalness, certain limitations.

Health risk assessment and development of human health ambient water quality criteria for PBDEs in China.

Polybrominated diphenyl ethers (PBDEs) are not only a class of highly efficient brominated flame retardants (BFRs) but also a class of typical persistent organic pollutants (POPs) that are persistent and widely distributed in various environmental media. This study examined the concentrations of PBDEs in five environmental media (water, soil, air, dust, and food) and two human body media (human milk and blood) in China from 2010 to 2020. In addition, this study conducted multi-pathway exposure health risk assessments of populations of different ages in urban, rural, key regions, and industrial factories using the Monte-Carlo simulation.

Responses of Low-Quality Soil Microbial Community Structure and Activities to Application of a Mixed Material of Humic Acid, Biochar, and Super Absorbent Polymer.

Low-quality soil for land reuse is a crucial problem in vegetation quality and especially to waste disposal sites in mining areas. It is necessary to find suitable materials to improve the soil quality and especially to increase soil microbial diversity and activity. In this study, pot experiments were conducted to investigate the effect of a mixed material of humic acid, super absorbent polymer and biochar on low-quality soil indexes and the microbial community response.

Nitrogen and phosphorus adsorption in aqueous solutions by humic acids from weathered coal: isotherm, kinetics and thermodynamic analysis.

The aim of this study was to reveal the mechanism of nitrogen and phosphorus adsorption by humic acids (HAs). HAs were extracted from weathered coal and used as adsorbents of urea-N and phosphate-P in water. The effect of different factors was considered, such as the initial concentration of urea-N and phosphate-P, temperature, and pH.

Heavy metals and metalloids in the surface sediments of the Xiangjiang River, Hunan, China: distribution, contamination, and ecological risk assessment.

Here, we aim to determine the distribution, ecological risk and sources of heavy metals and metalloids in the surface sediments of the Xiangjiang River, Hunan Province, China. Sixty-four surface sediment samples were collected in 16 sites of the Xiangjiang River, and the concentrations of ten heavy metals and metalloids (Mn, Zn, Cr, V, Pb, Cu, As, Ni, Co, and Cd) in the sediment samples were investigated using an inductively coupled plasma mass spectrometer (ICP-MS) and an atomic fluorescence spectrophotometer (AFS), respectively. The results showed that the mean concentrations of the ten heavy metals and metalloids in the sediment samples followed the order Mn > Zn > Cr > V > Pb > Cu > As ≈ Ni >Co > Cd.