Three new terpenoid derivatives from the deep-sea-derived fungus DFFSCS007.

Three new terpenoid derivatives (1,6,7)-hydrobenzosydowic acid (), (1 ,6,7)-hydrobenzosydowic acid (), and (7 ,10)-11-dehydroxy-iso-10-hydroxysydowic acid (), along with the known analogues ()-2-(1-(4-nitrobenzoyl)pyrrolidine-2-carboxamido)benzoic acid () and trihydroxybutyl ester of 4-carboxydiorcinol () were isolated from the deep-sea-derived fungus DFFSCS007. Their structures were determined by spectroscopic analysis. Compound with a nitrobenzene group was isolated from nature for the first time.

Multi-target anti-MRSA mechanism and antibiotic synergistic effect of marine alkaloid Ascomylactam A in vitro and in vivo against clinical MRSA strains.

Methicillin-resistant Staphylococcus aureus (MRSA), as a kind of multi-drug resistant bacteria, often causes serious sanitary infection problems. Marine fungi are seen as a promising source of lead compounds for antibiotics. In this research, the antibacterial activity, antibiotic synergistic effect and mechanism of the alkaloid Ascomylactam A (AsA) derived from the marine fungus Microascus sp.

Prenylated indole diketopiperazine alkaloids as phosphatase inhibitors from the marine-derived fungus Talaromyces purpureogenus.

Six previously undescribed prenylated indole diketopiperazine alkaloids, talaromyines A-F (1-6), were isolated from the marine-derived fungus Talaromyces purpureogenus SCSIO 41517. Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic data including NMR, HR-ESI-MS, and electronic circular dichroism calculations, together with chemical analysis of hydrolysates. Compounds 1-5 represent the first example of spirocyclic indole diketopiperazines biosynthesized from the condensation of L-tryptophan and L-alanine.

Metabolic mechanism of astaxanthin biosynthesis in Xanthophyllomyces dendrorhous in response to sodium citrate treatment.

Astaxanthin is an important ketocarotenoid widely used in industries. However, its application is limited because of its low yield. Sodium citrate (Na-citrate), one of the major carbon sources for microorganisms, can promote cell growth and product accumulation.

Mapping of secondary forest age in China using stacked generalization and Landsat time series.

A national distribution of secondary forest age (SFA) is essential for understanding the forest ecosystem and carbon stock in China. While past studies have mainly used various change detection algorithms to detect forest disturbance, which cannot adequately characterize the entire forest landscape. This study developed a data-driven approach for improving performances of the Vegetation Change Tracker (VCT) and Continuous Change Detection and Classification (CCDC) algorithms for detecting the establishment of forest stands.

New Antibacterial Peptaibiotics against Plant and Fish Pathogens from the Deep-Sea-Derived Fungus EIODSF 020.

Bacterial diseases could severely harm agricultural production. To develop new antibacterial agents, the secondary metabolites of a deep-sea-derived fungus EIODSF 020 with antibacterial activities against plant and fish pathogens were investigated by a bioassay-guided approach, which led to the isolation of 11 new peptaibiotics, simplicpeptaibs A-K (-). They contain 16-19 residues, including β-alanine, tyrosine, or tyrosine -sulfate, that were rarely present in peptaibiotics.

Microascones, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus sp. SCSIO 41821.

Eight new decahydrofluorene-class alkaloids, microascones A and B ( and ), 2,3-epoxyphomapyrrolidone C (), 14,16-epiascomylactam B (), 24-hydroxyphomapyrrolidone A (), and microascones C-E (-), along with five known analogs (-) were isolated from the marine-derived fungus sp. SCSIO 41821. Compounds and have an unprecedented complex macrocyclic alkaloid skeleton with a 6/5/6/5/6/5/13 polycyclic system.

HPPO-Derived Meroterpenoids from the Marine-Derived Fungus sp. SCSIO 41691.

Seven new 4-hydroxy-6-phenyl-2-pyran-2-one (HPPO) derived meroterpenoids, 1-methyl-12a,12b-epoxyarisugacin M (), 1-methyl-4a,12b-epoxyarisugacin M (), 2,3-dihydroxy-3,4a-epoxy-12a-dehydroxyisoterreulactone A (), 2-hydroxy-12a-dehydroxyisoterreulactone A (), 3'-demethoxyterritrems B' (), 4a-hydroxyarisugacin P (), and 1-epi-arisugacin H (), together with two known analogues ( and ), were isolated from the marine-derived fungal strain sp. SCSIO 41691. Their structures were elucidated by spectroscopic methods, and the absolute configurations of compounds and were determined by single-crystal X-ray diffraction.

Strategies for high cell density cultivation of and its potential metabolism.

Currently, there is significant interest in as a promising next-generation probiotic, making it a hot topic in scientific research. However, to achieve efficient industrial production, there is an urgent need to develop an culture method to achieve high biomass using low-cost carbon sources such as glucose. This study aims to explore the high-density fermentation strategy of by optimizing the culture process.

Lecanicilliums A-F, Thiodiketopiperazine-Class Alkaloids from a Mangrove Sediment-Derived Fungus .

Six new thiodiketopiperazine-class alkaloids lecanicilliums A-F were isolated from the mangrove sediment-derived fungus SCSIO41702, together with thirteen known analogues. Their structures were determined by spectroscopic analysis. The absolute configurations were determined by quantum chemical calculations.

Tuning the Dynamic Properties of Epoxy Vitrimers via Bioinspired Polymer-Nanoparticle Bond Dynamics.

In this work, FeO nanoparticles anchored with dopamine molecules were developed via bioinspired iron-catechol coordination interactions, and the dopamine-modified FeO surface was linked to the matrix through strong interfacial interactions between the nanoparticles and the epoxy vitrimer. Results showed that the typical dynamic parameters of vitrimer could be readily adjusted in the epoxy vitrimer composites. These findings demonstrate that it is efficient to adjust the dynamic properties of vitrimers by introducing the metal-coordination bonds into epoxy vitrimer networks.

Transesterification of phosphatidylcholine with DHA-rich algal oil using immobilized Candida antarctica lipase B to produce DHA-phosphatidylcholine.

Docosahexaenoic acid (DHA) enriched with phospholipids (PLs) (DHA-PLs) is a type of structured PL with good physicochemical and nutritional properties. Compared to PLs and DHA, DHA-PLs has higher bioavailability and structural stability and many nutritional benefits. To improve the enzymatic synthesis of DHA-PLs, this study investigated the preparation of phosphatidylcholine (PC) enriched with DHA (DHA-PC) via enzymatic transesterification of algal oil, which is rich in DHA-triglycerides, using immobilized Candida antarctica lipase B (CALB).

Two new linear peptides from the marine-derived fungus sp. SCSIO 41512.

Two new linear peptides, penicamides A and B ( and ), together with four known analogous were isolated from the extracts of the marine-derived fungus sp. SCSIO 41512. Their structures were elucidated by analysis of 1D/2D NMR data and HRESI-MS.

Punicesterones A-G, polyhydroxylated mycoecdysteroids from the deep-sea-derived fungus Aspergillus puniceus SCSIO z021.

Seven undescribed polyhydroxylated mycoecdysteroids, punicesterones A-G, along with two known analogues, were isolated from the deep-sea-derived fungal strain Aspergillus puniceus SCSIO z021 (Trichocomaceae). Their structures with absolute configurations were elucidated by a combination of extensive NMR spectroscopic analysis, HRESIMS data, and single-crystal X-ray diffraction experiments. Punicesterone An unexpectedly possessed a nicotinoyl unit substituted at C-22 of a typical ecdysteroid skeleton.

An Effective Approach to Improve the Thermal Conductivity, Strength, and Stress Relaxation of Carbon Nanotubes/Epoxy Composites Based on Vitrimer Chemistry.

An effective method was developed to improve the interfacial interaction between Mutiwalled carbon nanotubes (MWCNTs) and epoxy matrix. The performance of thermal conductivity and strength of the epoxy vitrimer were enhanced by polydopamine (PDA) coating. Polydopamine is a commonly used photothermal agent, which of course, was effective in modifying MWCNTs used in photoresponsive epoxy resin.

Pyrrospirones K-Q, Decahydrofluorene-Class Alkaloids from the Marine-Derived Fungus sp. SCSIO 41512.

Seven new decahydrofluorene-class alkaloids, pyrrospirones K-Q (-), together with six known analogues (-) were isolated from the marine-derived fungal strain sp. SCSIO 41512. Their structures were determined by extensive spectroscopic analysis, and their absolute configurations were established by single-crystal X-ray diffraction analysis and quantum chemical calculations of electronic circular dichroism spectra.

Isoquinoline Alkaloids as Protein Tyrosine Phosphatase Inhibitors from a Deep-Sea-Derived Fungus .

Puniceusines A-N (-), 14 new isoquinoline alkaloids, were isolated from the extracts of a deep-sea-derived fungus, SCSIO z021. Their structures were elucidated by spectroscopic analyses. The absolute configuration of was determined by ECD calculations, and the structures of and were further confirmed by a single-crystal X-ray diffraction analysis.

Fusidane-Type Antibiotics from the Marine-Derived Fungus sp. SCSIO 41513.

Simplifusidic acids A-K (-), 11 new fusidane-type nortriterpenoids, were isolated from the marine-derived fungus sp. SCSIO 41513. Compound possessed an unprecedented fusidane triterpene skeleton with a 6/6/7/5/5 polycyclic system.

Antifungal peptides from the marine gorgonian-associated fungus Aspergillus sp. SCSIO41501.

Three undescribed cyclic lipopeptides maribasins C-E and four undescribed linear peptides aspergillipeptides H-K together with three known analogous maribasins A-B and marihysin A were isolated from the marine gorgonian-associated fungus Aspergillus sp. SCSIO 41501 (Trichocomaceae). Their structures were determined by spectroscopic analysis, and their absolute configurations were further confirmed by Marfey's methods.

Talaromynoids A-I, Highly Oxygenated Meroterpenoids from the Marine-Derived Fungus SCSIO 41517 and Their Lipid Accumulation Inhibitory Activities.

Nine new highly oxygenated 3,5-dimethylorsellinic acid-derived meroterpenoids, talaromynoids A-I (-), were isolated from the marine-derived fungus SCSIO 41517. Their structures including absolute configurations were elucidated by HRMS, NMR, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. Compounds and - possessed unprecedented 5/7/6/5/6/6, 6/7/6/6/6/5, 6/7/6/5/6/5/4, and 7/6/5/6/5/4 polycyclic systems, respectively.

Talaromyoxaones A and B: Unusual Oxaphenalenone Spirolactones as Phosphatase Inhibitors from the Marine-Derived Fungus SCSIO 41517.

(+)- and (-)-talaromyoxaones A and B ( and , respectively), two new oxaphenalenone derivatives with a hemiacetal frame and an unprecedented spirolactone frame of a 2',3,4'-spiro[isobenzofuran-1,3'-pyran]-3-one unit that show biosynthetic enantiodivergence, and two new oxaphenalenone analogues (±)-11-apopyrenulin () and (+)- or (-)-abeopyrenulin () were isolated from the marine-derived fungus SCSIO 41517. Their structures were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and quantum chemical calculations of ECD spectra. Compounds and showed selective inhibitory activity against phosphatases SHP1, SHP2, and MEG2 with IC values of 1.

Miq. and Its Active Compound -Coumaric Acid Promote Brain-Derived Neurotrophic Factor Signaling for Inducing Hippocampal Neurogenesis and Improving Post-cerebral Ischemic Spatial Cognitive Functions.

Alpinia Miq. (AOM) is a medicinal herb for improving cognitive functions in traditional Chinese medicine for poststroke treatment, but its efficacies and underlying mechanisms remain unknown. In the present study, we tested the hypothesis that AOM could induce adult hippocampal neurogenesis and improve poststroke cognitive impairment inducing brain-derived neurotrophic factor (BDNF) signaling pathway.

Mycotoxins as inhibitors of protein tyrosine phosphatases from the deep-sea-derived fungus Aspergillus puniceus SCSIO z021.

Nine new xanthone-type and anthraquinone-type mycotoxins including austocystins J-N (1-5), 7-chloro versicolorin A (6), 3'-hydroxy-8-O-methyl versicolorin B (7), 8-O-methyl versiconol (8) and 2',3'-dihydroxy versiconol (9), together with 17 known analogues (10-26) were isolated from an extract of the deep-sea-derived fungus Aspergillus puniceus SCSIO z021. Their structures were elucidated by detailed analysis of spectroscopic data, and their absolute configurations were further determined by quantum chemical calculations of ECD spectra or comparison of the experimental ECD spectra. Eleven hydrogenated austocystins were synthesized from 1-2, 10-15 and 17 by catalytic hydrogenation for bioactivities evaluation.