Silibinin alleviates acute liver failure by modulating AKT/GSK3β/Nrf2/GPX4 pathway.

Silibinin (Sil) is a major bioactive component of silymarin, extracted from the fruit and seeds of Silybum marianum. Silibinin meglumine (SM) is a water-soluble derivative of silibinin that has shown significant potential in liver fibrosis. However, the potential effects and underlying mechanisms of SM on acute liver failure (ALF) are still not fully understood.

The chain-mediating effect of Crp, BMI on the relationship between dietary intake of live microbes and hyperlipidaemia.

Background: Inflammation and obesity are the risk factors for hyperlipidaemia. Nonetheless, research regarding the association between dietary live microbes intake and hyperlipidaemia is lacking. Therefore, this study focused on revealing the relationship between them and mediating roles of inflammation and obesity.

Dietary serine intake is associated with cognitive function among US adults.

: Diet can modify the risk of cognitive decline. However, research on the relationship between dietary intake of serine and cognitive decline remains limited and this study aims to reveal the relationship between them. : Data from the National Health and Nutrition Examination Survey (NHANES) 1988-1994 ( = 1837) were used to explore the relationship between dietary intakes of serine and cognitive function through quantile multiple linear analysis and restricted cubic splines (RCS) regression.

Circ_0027885 sponges miR-203-3p to regulate RUNX2 expression and alleviates osteoporosis progression.

Background: Osteoporosis (OP) is a progressive metabolic disorder that is difficult to cure clinically. The molecular mechanisms of OP urgently need to be further examined. This study was designed to explore the potential function of circ_0027885 during osteogenic differentiation, as well as the systematic interactions among circ_0027885, miR-203-3p and runt-related transcription factor 2 (RUNX2).

Design approach of perforated labyrinth-based acoustic metasurface for selective acoustic levitation manipulation.

This paper proposes a metasurface design approach with perforated labyrinthine path coil structure to manipulate the acoustic transmission with inexpensive materials. The medium in the labyrinthine path coils in this design is air, but not limited to air. A systematic approach has been proposed for the unit cell design of acoustic metamaterials with adjustable resonance peak frequencies and bandgap width.

Urotensin-II gene rs228648 polymorphism associated with the risk of diabetes mellitus.

: Urotensin-II (UII) rs228648 polymorphism has been reported to be associated with the risk of diabetes mellitus (DM) with inconsistent results. The present study sought to reassess the relationship between this polymorphism and susceptibility to DM by meta-analysis.: Relevant eligible studies and whole genome association study (GWAS) data electronically searched were pooled to evaluate the strength of the association with odds ratios (ORs) and 95% confidence intervals (CIs).

Three-dimensional reconstructed eccrine sweat glands with vascularization and cholinergic and adrenergic innervation.

Functional integrity of the regenerated tissues requires not only structural integrity but also vascularization and innervation. We previously demonstrated that the three-dimensional (3D) reconstructed eccrine sweat glands had similar structures as those of the native ones did, but whether the 3D reconstructed glands possessing vascularization and innervation was still unknown. In the study, Matrigel-embedded eccrine sweat gland cells were implanted under the inguinal skin.